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    GLRX glutaredoxin [ Homo sapiens (human) ]

    Gene ID: 2745, updated on 21-Dec-2019

    Summary

    Official Symbol
    GLRXprovided by HGNC
    Official Full Name
    glutaredoxinprovided by HGNC
    Primary source
    HGNC:HGNC:4330
    See related
    Ensembl:ENSG00000173221 MIM:600443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRX; GRX1
    Summary
    This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in kidney (RPKM 54.1), small intestine (RPKM 45.6) and 22 other tissues See more
    Orthologs

    Genomic context

    See GLRX in Genome Data Viewer
    Location:
    5q15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (95813849..95822873, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (95149553..95158577, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379090 Neighboring gene spermatogenesis associated 9 Neighboring gene Rho related BTB domain containing 3 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 11 Neighboring gene uncharacterized LOC102724720 Neighboring gene GGCT pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Grx1 efficiently catalyzes gp120 and CD4 disulfide reduction in vitro. Purified anti-Grx1 antibodies are shown to inhibit the Grx1 activity in vitro and block HIV-1 replication in cultured peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ43648, MGC117407

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione disulfide oxidoreductase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    glutathione oxidoreductase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing small molecule interconversion TAS
    Traceable Author Statement
    more info
     
    positive regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deglutathionylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutaredoxin-1
    Names
    TTase-1
    thioltransferase
    thioltransferase-1
    NP_001112362.1
    NP_001230587.1
    NP_001230588.1
    NP_002055.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029797.1 RefSeqGene

      Range
      5148..14025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001118890.2NP_001112362.1  glutaredoxin-1

      See identical proteins and their annotated locations for NP_001112362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AW128930, AW792936, BC010965, BP196332, D21238
      Consensus CDS
      CCDS4078.1
      UniProtKB/Swiss-Prot
      P35754
      UniProtKB/TrEMBL
      A0A024RAM2
      Related
      ENSP00000237858.6, ENST00000237858.11
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin
    2. NM_001243658.2NP_001230587.1  glutaredoxin-1

      See identical proteins and their annotated locations for NP_001230587.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC008821, BG547098
      Consensus CDS
      CCDS4078.1
      UniProtKB/Swiss-Prot
      P35754
      UniProtKB/TrEMBL
      A0A024RAM2
      Related
      ENSP00000427353.1, ENST00000505427.1
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin
    3. NM_001243659.1NP_001230588.1  glutaredoxin-1

      See identical proteins and their annotated locations for NP_001230588.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR, compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AA485178, AC008821, BP196332, BU949348
      Consensus CDS
      CCDS4078.1
      UniProtKB/Swiss-Prot
      P35754
      UniProtKB/TrEMBL
      A0A024RAM2
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin
    4. NM_002064.3NP_002055.1  glutaredoxin-1

      See identical proteins and their annotated locations for NP_002055.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AW128930, AW792936, BC010965, BE738446, BP196332, BX106369, D21238
      Consensus CDS
      CCDS4078.1
      UniProtKB/Swiss-Prot
      P35754
      UniProtKB/TrEMBL
      A0A024RAM2
      Related
      ENSP00000369314.4, ENST00000379979.8
      Conserved Domains (1) summary
      TIGR02180
      Location:1599
      GRX_euk; Glutaredoxin

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      95813849..95822873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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