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    DESI1 desumoylating isopeptidase 1 [ Homo sapiens (human) ]

    Gene ID: 27351, updated on 17-Jun-2019

    Summary

    Official Symbol
    DESI1provided by HGNC
    Official Full Name
    desumoylating isopeptidase 1provided by HGNC
    Primary source
    HGNC:HGNC:24577
    See related
    Ensembl:ENSG00000100418 MIM:614637
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    POST; DESI2; DeSI-1; PPPDE2; FAM152B; D15Wsu75e; DJ347H13.4
    Expression
    Ubiquitous expression in testis (RPKM 7.4), esophagus (RPKM 4.9) and 25 other tissues See more
    Orthologs

    Genomic context

    See DESI1 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (41598028..41621077, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41994032..42017079, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene cold shock domain containing C2 Neighboring gene phosphomannomutase 1 Neighboring gene X-ray repair cross complementing 6 Neighboring gene protein LLP homolog pseudogene Neighboring gene small nuclear ribonucleoprotein 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC138384

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    desumoylating isopeptidase 1
    Names
    PPPDE peptidase domain containing 2
    PPPDE peptidase domain-containing protein 2
    desumoylating isopeptidase 2
    family with sequence similarity 152, member B
    polyubiquitinated substrate transporter

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015704.3NP_056519.1  desumoylating isopeptidase 1

      See identical proteins and their annotated locations for NP_056519.1

      Status: VALIDATED

      Source sequence(s)
      AL023553, BC039554, BC093956, BX403547, BX478162
      Consensus CDS
      CCDS33652.1
      UniProtKB/Swiss-Prot
      Q6ICB0
      Related
      ENSP00000263256.6, ENST00000263256.7
      Conserved Domains (1) summary
      pfam05903
      Location:7149
      Peptidase_C97; PPPDE putative peptidase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      41598028..41621077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005261571.4XP_005261628.1  desumoylating isopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_005261628.1

      Conserved Domains (1) summary
      pfam05903
      Location:7144
      Peptidase_C97; PPPDE putative peptidase domain

    RNA

    1. XR_001755216.1 RNA Sequence

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