U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    APOBEC3C apolipoprotein B mRNA editing enzyme catalytic subunit 3C [ Homo sapiens (human) ]

    Gene ID: 27350, updated on 2-May-2024

    Summary

    Official Symbol
    APOBEC3Cprovided by HGNC
    Official Full Name
    apolipoprotein B mRNA editing enzyme catalytic subunit 3Cprovided by HGNC
    Primary source
    HGNC:HGNC:17353
    See related
    Ensembl:ENSG00000244509 MIM:607750; AllianceGenome:HGNC:17353
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3
    Summary
    This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 33.1), testis (RPKM 26.8) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See APOBEC3C in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (39014257..39020352)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39484669..39490772)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39410262..39416357)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39370179-39370956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13737 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:39380734-39381933 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:39382500-39382695 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3B Neighboring gene APOBEC3B antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:39394090-39394730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39406643-39407144 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr22:39409474-39410092 and GRCh37_chr22:39410093-39410710 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39415894-39416734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39417574-39418413 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:39423978-39424906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39426361-39427157 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:39432783-39433673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39437791-39438568 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:39439415-39439645 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3F Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:39445317-39446516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:39448525-39449459

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Single-virion fluorescence microscopy analysis demonstrates that the efficiency of A3G-YFP and A3F-YFP incorporation into HIV-1 Gag-CeFP virions is higher than that of A3C-YFP incorporation into HIV-1 Gag-CeFP virions PubMed
    gag Interaction of APOBEC3C with HIV-1 Gag is required for its incorporation into Vif(-) virions and the interaction between APOBEC3C and Gag is MA domain-dependent and 7SL RNA-dependent PubMed
    Vif vif HIV-1 Vif degrades APOBEC3C and APOBEC3F and is dependent on Vif F1, F2, and F3 box mutations involving residues D14, R15, M16, W79, D172, and W174 PubMed
    vif HIV-1 Vif degrades APOBEC3F and APOBEC3C PubMed
    vif HIV-1 Vif internal amino acid salt bridge (E171-K167-D101) mediates human APOBEC3C and APOBEC3F degradation PubMed
    vif APOBEC3C restricts HIV-1 replication by causing G to A mutations in viral DNA replication intermediates; HIV-1 Vif binds to and destabilizes APOBEC3C PubMed
    vif APOBEC3C levels in virus particles are increased when the virus particles are produced from N.41 treated 293T cells in the presence of Vif expression PubMed
    vif Immunoblotting and crystal structure analyses reveal ten amino acids L72, F75, C76, I79, L80, S81, Y86, E106, F107, and H111 between the alpha 2 and alpha 3 helices of APOBEC3C are involved in forming the Vif-interaction interface PubMed
    vif CBF-beta-mediated increase of HIV-1 Vif steady-state levels results in decreased cellular levels of all Vif-sensitive APOBEC proteins (A3C, A3D, A3F, A3G, and A3H haplotype II) PubMed
    vif A potent small molecular compound VEC-5 protects APOBEC3G, APOBEC3F, and APOBEC3C from HIV-1 Vif-induced degradation and enhances A3G incorporation into HIV-1 virions by inhibiting the interaction between Vif and elongin C PubMed
    vif Stress causes A3A, A3B, A3C, and A3F to co-localize efficiently with Vif(IIIB) and mRNA-PABP1 complexes in stress granules PubMed
    vif Vif(IIIB) induces A3A, A3B, and A3C emigration from the nucleus to the cytosol and thereby causes net increases in their cytosolic concentrations and anti-HIV-1 activities PubMed
    vif Small molecule RN-18 specifically inhibits HIV-1 Vif-mediated downregulation of APOBEC3C/F/G proteins by decreasing Vif protein levels when Vif interacts with these proteins PubMed
    vif A novel conserved 69YXXL72 motif in HIV-1 Vif regulates A3C expression in cells PubMed
    vif The LV portion of the Vif SLV/Ix4Yx9Y motif is required for optimal suppression of A3C or A3DE PubMed
    vif HIV-1 Vif K22E and RH41/42AA mutants are able to suppress the anti-viral activity of A3C, but are ineffective in suppressing the anti-viral activity of A3G. K22, R41, and H42 residues are important for Vif-mediated degradation of A3G, but not A3C PubMed
    vif Amino acid E289 in the EFLARH sequence of A3C is critical for HIV-1 Vif-mediated degradation PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of APOBEC3C in human monocyte-derived macrophages PubMed
    matrix gag Interaction of APOBEC3C with HIV-1 Gag is required for its incorporation into Vif(-) virions and the interaction between APOBEC3C and Gag is MA domain-dependent and 7SL RNA-dependent PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37251, MGC19485

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA dC->dU-editing enzyme APOBEC-3C
    Names
    apolipoprotein B editing enzyme catalytic polypeptide-like 3C
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
    phorbolin I
    probable DNA dC->dU-editing enzyme APOBEC-3C
    NP_055323.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014508.3NP_055323.2  DNA dC->dU-editing enzyme APOBEC-3C

      See identical proteins and their annotated locations for NP_055323.2

      Status: REVIEWED

      Source sequence(s)
      AL022318
      Consensus CDS
      CCDS13983.1
      UniProtKB/Swiss-Prot
      B2R884, Q5JZ92, Q7Z2N7, Q96F12, Q9NRW3
      UniProtKB/TrEMBL
      M4VP52
      Related
      ENSP00000355340.3, ENST00000361441.5
      Conserved Domains (1) summary
      pfam18772
      Location:12190
      APOBEC2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      39014257..39020352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      39484669..39490772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)