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    VENTX VENT homeobox [ Homo sapiens (human) ]

    Gene ID: 27287, updated on 18-Sep-2024

    Summary

    Official Symbol
    VENTXprovided by HGNC
    Official Full Name
    VENT homeoboxprovided by HGNC
    Primary source
    HGNC:HGNC:13639
    See related
    Ensembl:ENSG00000151650 MIM:607158; AllianceGenome:HGNC:13639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NA88A; HPX42B; VENTX2
    Summary
    This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 1.9), spleen (RPKM 1.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See VENTX in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133237855..133241928)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134193345..134197419)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135051359..135055432)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene kinase non-catalytic C-lobe domain containing 1 Neighboring gene uncharacterized LOC105378573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135013107-135013853 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135013854-135014599 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135038599-135039222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:135043703-135044502 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135045303-135046102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135048520-135049124 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135050334-135050937 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135050938-135051542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135051543-135052146 Neighboring gene undifferentiated embryonic cell transcription factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135056640-135057492 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:135057814-135059013 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135060766-135061280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135061797-135062311 Neighboring gene MIR202 host gene Neighboring gene microRNA 202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135075828-135076804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135084013-135084769 Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135087865-135088514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135089815-135090462

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC119910, MGC119911

    General protein information

    Preferred Names
    homeobox protein VENTX
    Names
    VENT homeobox homolog
    VENT-like homeobox 2
    VENT-like homeobox protein 2
    hemopoietic progenitor homeobox protein VENTX2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014468.4NP_055283.1  homeobox protein VENTX

      See identical proteins and their annotated locations for NP_055283.1

      Status: REVIEWED

      Source sequence(s)
      AL445199
      Consensus CDS
      CCDS7675.1
      UniProtKB/Swiss-Prot
      O95231, Q32MZ3
      Related
      ENSP00000357556.5, ENST00000325980.10
      Conserved Domains (1) summary
      pfam00046
      Location:95147
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      133237855..133241928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      134193345..134197419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)