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    IL37 interleukin 37 [ Homo sapiens (human) ]

    Gene ID: 27178, updated on 18-Jun-2019

    Summary

    Official Symbol
    IL37provided by HGNC
    Official Full Name
    interleukin 37provided by HGNC
    Primary source
    HGNC:HGNC:15563
    See related
    Ensembl:ENSG00000125571 MIM:605510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
    Summary
    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward skin (RPKM 8.8) See more
    Orthologs

    Genomic context

    See IL37 in Genome Data Viewer
    Location:
    2q14.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (112908885..112918882)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113670548..113676459)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-linked inhibitor of apoptosis pseudogene 3 Neighboring gene uncharacterized LOC105373563 Neighboring gene cyclin dependent kinase 8 pseudogene 2 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 23 Neighboring gene interleukin 36 gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of lung function phenotypes in a founder population.
    NHGRI GWA Catalog
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-1 receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    interleukin-1 receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to cytokine stimulus TAS
    Traceable Author Statement
    more info
     
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of interleukin-6 production IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-37
    Names
    FIL1 zeta
    IL-1 zeta
    IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
    IL-1X protein
    IL1F7 (canonical product IL-1F7b)
    interleukin 1 family member 7
    interleukin 1, zeta
    interleukin-1 homolog 4
    interleukin-1 superfamily z
    interleukin-1-related protein
    interleukin-23

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029219.1 RefSeqGene

      Range
      5001..10912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014439.3NP_055254.2  interleukin-37 isoform 1 precursor

      See identical proteins and their annotated locations for NP_055254.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AF167368
      Consensus CDS
      CCDS2103.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000263326.3, ENST00000263326.7
      Conserved Domains (1) summary
      cl00094
      Location:59204
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. NM_173202.1NP_775294.1  interleukin-37 isoform 2

      See identical proteins and their annotated locations for NP_775294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1, resulting an isoform (2) that lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AB451333, AF167368
      Consensus CDS
      CCDS2104.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000263327.3, ENST00000352179.7
      Conserved Domains (1) summary
      cl00094
      Location:38183
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    3. NM_173203.1NP_775295.1  interleukin-37 isoform 3

      See identical proteins and their annotated locations for NP_775295.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons but maintains the reading frame, compared to variant 1, resulting an isoform (3) that lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AF167368, AY071841
      Consensus CDS
      CCDS2105.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000263328.3, ENST00000349806.7
      Conserved Domains (1) summary
      cl00094
      Location:47143
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    4. NM_173204.1NP_775296.1  interleukin-37 isoform 4

      See identical proteins and their annotated locations for NP_775296.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame coding exon, compared to variant 1, resulting an isoform (4) that lacks an internal region, as compared to isoform 1.
      Source sequence(s)
      AF167368
      Consensus CDS
      CCDS2106.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000309208.3, ENST00000353225.7
      Conserved Domains (1) summary
      cl00094
      Location:68164
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    5. NM_173205.1NP_775297.1  interleukin-37 isoform 5

      See identical proteins and their annotated locations for NP_775297.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' sequence, compared to variant 1. The resulting isoform (5) has a distinct and shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AF167368, AF201832
      Consensus CDS
      CCDS2107.1
      UniProtKB/Swiss-Prot
      Q9NZH6
      Related
      ENSP00000309883.2, ENST00000311328.2
      Conserved Domains (1) summary
      cl00094
      Location:33178
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      112908885..112918882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510964.3XP_011509266.1  interleukin-37 isoform X2

      See identical proteins and their annotated locations for XP_011509266.1

      UniProtKB/Swiss-Prot
      Q9NZH6
      Conserved Domains (1) summary
      cl00094
      Location:68164
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
    2. XM_011510963.3XP_011509265.1  interleukin-37 isoform X1

      See identical proteins and their annotated locations for XP_011509265.1

      UniProtKB/Swiss-Prot
      Q9NZH6
      Conserved Domains (1) summary
      cl00094
      Location:59204
      IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
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