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    SEC22A SEC22 homolog A, vesicle trafficking protein [ Homo sapiens (human) ]

    Gene ID: 26984, updated on 15-Jun-2019

    Summary

    Official Symbol
    SEC22Aprovided by HGNC
    Official Full Name
    SEC22 homolog A, vesicle trafficking proteinprovided by HGNC
    Primary source
    HGNC:HGNC:20260
    See related
    Ensembl:ENSG00000121542 MIM:612442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC22L2
    Summary
    The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. [provided by RefSeq, Nov 2008]
    Expression
    Ubiquitous expression in testis (RPKM 4.5), thyroid (RPKM 2.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See SEC22A in Genome Data Viewer
    Location:
    3q21.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (123201927..123274136)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (122920774..122992983)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268448 Neighboring gene semaphorin 5B Neighboring gene protein disulfide isomerase family A member 5 Neighboring gene microRNA 7110 Neighboring gene adenylate cyclase 5 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
      COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemCOPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles wer...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vesicle-trafficking protein SEC22a
    Names
    SEC22 vesicle trafficking protein homolog A
    SEC22 vesicle trafficking protein-like 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012430.5NP_036562.2  vesicle-trafficking protein SEC22a

      See identical proteins and their annotated locations for NP_036562.2

      Status: REVIEWED

      Source sequence(s)
      AC112503, BC007122, BG613364, BX118915
      Consensus CDS
      CCDS3021.1
      UniProtKB/Swiss-Prot
      Q96IW7
      Related
      ENSP00000417972.1, ENST00000492595.6
      Conserved Domains (1) summary
      pfam13774
      Location:38114
      Longin; Regulated-SNARE-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      123201943..123274136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512675.3XP_011510977.1  vesicle-trafficking protein SEC22a isoform X1

      See identical proteins and their annotated locations for XP_011510977.1

      UniProtKB/Swiss-Prot
      Q96IW7
      Related
      ENSP00000420343.2, ENST00000473494.6
      Conserved Domains (1) summary
      pfam13774
      Location:38114
      Longin; Regulated-SNARE-like domain
    2. XM_011512676.3XP_011510978.1  vesicle-trafficking protein SEC22a isoform X1

      See identical proteins and their annotated locations for XP_011510978.1

      UniProtKB/Swiss-Prot
      Q96IW7
      Conserved Domains (1) summary
      pfam13774
      Location:38114
      Longin; Regulated-SNARE-like domain
    3. XM_011512673.3XP_011510975.1  vesicle-trafficking protein SEC22a isoform X1

      See identical proteins and their annotated locations for XP_011510975.1

      UniProtKB/Swiss-Prot
      Q96IW7
      Conserved Domains (1) summary
      pfam13774
      Location:38114
      Longin; Regulated-SNARE-like domain
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