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    LATS2 large tumor suppressor kinase 2 [ Homo sapiens (human) ]

    Gene ID: 26524, updated on 28-Oct-2024

    Summary

    Official Symbol
    LATS2provided by HGNC
    Official Full Name
    large tumor suppressor kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:6515
    See related
    Ensembl:ENSG00000150457 MIM:604861; AllianceGenome:HGNC:6515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KPM
    Summary
    This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 10.9), gall bladder (RPKM 10.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LATS2 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (20973036..21061586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20166164..20254674, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21547175..21635725, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein SA pseudogene 54 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21549761-21550262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21571219-21571758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21572540-21573076 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21608126-21608626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21609627-21610451 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21611543-21612531 Neighboring gene RNA, U4 small nuclear 9, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21624857-21625356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:21626645-21627146 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21634192-21635084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5160 Neighboring gene uncharacterized LOC105370104 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649238-21649738 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:21649739-21650239 Neighboring gene ribosomal protein S12 pseudogene 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hippo signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hippo signaling TAS
    Traceable Author Statement
    more info
     
    involved_in hormone-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inner cell mass cell fate commitment IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inner cell mass cellular morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of protein localization to nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of organ growth IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase LATS2
    Names
    LATS (large tumor suppressor, Drosophila) homolog 2
    LATS, large tumor suppressor, homolog 2
    kinase phosphorylated during mitosis protein
    large tumor suppressor homolog 2
    serine/threonine kinase KPM
    serine/threonine-protein kinase kpm
    warts-like kinase
    NP_055387.2
    XP_005266399.1
    XP_011533344.1
    XP_016876030.1
    XP_016876031.1
    XP_047286222.1
    XP_047286223.1
    XP_054230417.1
    XP_054230418.1
    XP_054230419.1
    XP_054230420.1
    XP_054230421.1
    XP_054230422.1
    XP_054230423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014572.3NP_055387.2  serine/threonine-protein kinase LATS2

      See identical proteins and their annotated locations for NP_055387.2

      Status: REVIEWED

      Source sequence(s)
      AF207547, AL161613, AL356285, BQ774580, DB452765
      Consensus CDS
      CCDS9294.1
      UniProtKB/Swiss-Prot
      B1AM47, Q9NRM7, Q9P2X1
      UniProtKB/TrEMBL
      Q59EB4
      Related
      ENSP00000372035.4, ENST00000382592.5
      Conserved Domains (3) summary
      cd05626
      Location:6661046
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:668973
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:101141
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      20973036..21061586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020542.2XP_016876031.1  serine/threonine-protein kinase LATS2 isoform X4

      UniProtKB/TrEMBL
      Q59EB4
    2. XM_005266342.1XP_005266399.1  serine/threonine-protein kinase LATS2 isoform X1

      See identical proteins and their annotated locations for XP_005266399.1

      UniProtKB/Swiss-Prot
      B1AM47, Q9NRM7, Q9P2X1
      UniProtKB/TrEMBL
      Q59EB4
      Conserved Domains (3) summary
      cd05626
      Location:6661046
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:668973
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:101141
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
    3. XM_047430266.1XP_047286222.1  serine/threonine-protein kinase LATS2 isoform X1

      UniProtKB/Swiss-Prot
      B1AM47, Q9NRM7, Q9P2X1
    4. XM_047430267.1XP_047286223.1  serine/threonine-protein kinase LATS2 isoform X4

    5. XM_017020541.2XP_016876030.1  serine/threonine-protein kinase LATS2 isoform X3

      UniProtKB/TrEMBL
      Q59EB4
    6. XM_011535042.3XP_011533344.1  serine/threonine-protein kinase LATS2 isoform X2

      Conserved Domains (3) summary
      cd05626
      Location:579959
      STKc_LATS2; Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2
      smart00220
      Location:581886
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21463
      Location:2454
      UBA_like_SF; UBA domain-like superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      20166164..20254674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374447.1XP_054230422.1  serine/threonine-protein kinase LATS2 isoform X4

    2. XM_054374443.1XP_054230418.1  serine/threonine-protein kinase LATS2 isoform X1

    3. XM_054374444.1XP_054230419.1  serine/threonine-protein kinase LATS2 isoform X1

    4. XM_054374448.1XP_054230423.1  serine/threonine-protein kinase LATS2 isoform X4

    5. XM_054374442.1XP_054230417.1  serine/threonine-protein kinase LATS2 isoform X1

    6. XM_054374446.1XP_054230421.1  serine/threonine-protein kinase LATS2 isoform X3

    7. XM_054374445.1XP_054230420.1  serine/threonine-protein kinase LATS2 isoform X2