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    TIPRL TOR signaling pathway regulator [ Homo sapiens (human) ]

    Gene ID: 261726, updated on 17-Jun-2019

    Summary

    Official Symbol
    TIPRLprovided by HGNC
    Official Full Name
    TOR signaling pathway regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:30231
    See related
    Ensembl:ENSG00000143155 MIM:611807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIP; TIP41; TIPRL1
    Summary
    TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See TIPRL in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (168178962..168202109)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168148171..168171352)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene glycine cleavage system protein H pseudogene 5 Neighboring gene G protein-coupled receptor 161 Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene ribosomal protein L34 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC3794

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TIP41-like protein
    Names
    TIP41, TOR signaling pathway regulator-like
    putative MAPK-activating protein PM10
    type 2A-interacting protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031800.3NP_001026970.1  TIP41-like protein isoform 2

      See identical proteins and their annotated locations for NP_001026970.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK313520, BC009506
      Consensus CDS
      CCDS30935.1
      UniProtKB/Swiss-Prot
      O75663
      Related
      ENSP00000356804.3, ENST00000367830.3
      Conserved Domains (1) summary
      pfam04176
      Location:56172
      TIP41; TIP41-like family
    2. NM_152902.5NP_690866.1  TIP41-like protein isoform 1

      See identical proteins and their annotated locations for NP_690866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK313520, AL021397
      Consensus CDS
      CCDS1270.1
      UniProtKB/Swiss-Prot
      O75663
      Related
      ENSP00000356807.2, ENST00000367833.7
      Conserved Domains (1) summary
      pfam04176
      Location:50218
      TIP41; TIP41-like family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      168178962..168202109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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