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    TTLL3 tubulin tyrosine ligase like 3 [ Homo sapiens (human) ]

    Gene ID: 26140, updated on 17-Jun-2019

    Summary

    Official Symbol
    TTLL3provided by HGNC
    Official Full Name
    tubulin tyrosine ligase like 3provided by HGNC
    Primary source
    HGNC:HGNC:24483
    See related
    Ensembl:ENSG00000214021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOTTL
    Expression
    Ubiquitous expression in ovary (RPKM 13.9), testis (RPKM 13.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See TTLL3 in Genome Data Viewer
    Location:
    3p25.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (9809915..9836365)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (9851632..9878040)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 8-oxoguanine DNA glycosylase Neighboring gene calcium/calmodulin dependent protein kinase I Neighboring gene transcriptional adaptor 3 Neighboring gene ARPC4-TTLL3 readthrough Neighboring gene actin related protein 2/3 complex subunit 4 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene microtubule affinity regulating kinase 2 pseudogene 1 Neighboring gene cell death inducing DFFA like effector c

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough ARPC4-TTLL3

    Readthrough gene: ARPC4-TTLL3, Included gene: ARPC4

    Homology

    Clone Names

    • FLJ13898, MGC120529, MGC120530, MGC120532, DKFZp434B103, DKFZp686D076

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-glycine ligase activity, initiating ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein polyglycylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyglycylation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    tubulin monoglycylase TTLL3
    Names
    tubulin tyrosine ligase-like family, member 3
    tubulin--tyrosine ligase-like protein 3
    NP_001021100.3
    NP_001352980.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025930.5NP_001021100.3  tubulin monoglycylase TTLL3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1), and represents use of a different promoter relative to variant 3.
      Source sequence(s)
      AC018809, AC022382, AK023960
      Consensus CDS
      CCDS43048.2
      UniProtKB/Swiss-Prot
      Q9Y4R7
      UniProtKB/TrEMBL
      J3KQB2
      Related
      ENSP00000392549.4, ENST00000426895.9
      Conserved Domains (1) summary
      pfam03133
      Location:356648
      TTL; Tubulin-tyrosine ligase family
    2. NM_001366051.2NP_001352980.1  tubulin monoglycylase TTLL3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR relative to variant 1, and represents use of a different promoter, resulting in the use of a downstream start codon relative to variant 1. The encoded isoform is shorter at the N-terminus relative to variant 1.
      Source sequence(s)
      AC018809, AC022382, AK023960
      Conserved Domains (1) summary
      pfam03133
      Location:213505
      TTL; Tubulin-tyrosine ligase family

    RNA

    1. NR_037162.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' terminal exons, and includes alternate internal exon structure, compared to variant 1. This variant is represented as non-coding due to the presence of multiple upstream ORFs that are predicted to inhibit the translation of the longest ORF; upstream ORF translation would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA742169, AC018809, AC022382, BC028169

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      9809915..9836365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015644.3: Suppressed sequence

      Description
      NM_015644.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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