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    POLDIP2 DNA polymerase delta interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 26073, updated on 6-Oct-2024

    Summary

    Official Symbol
    POLDIP2provided by HGNC
    Official Full Name
    DNA polymerase delta interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:23781
    See related
    Ensembl:ENSG00000004142 MIM:611519; AllianceGenome:HGNC:23781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p38; POLD4; PDIP38
    Summary
    This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
    Expression
    Ubiquitous expression in kidney (RPKM 32.9), adrenal (RPKM 29.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POLDIP2 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (28346633..28357527, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (29288484..29299376, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26673659..26684550, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 55 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:26609113-26610312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:26644505-26645330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11921 Neighboring gene transmembrane protein 97 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11922 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:26662195-26662386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8335 Neighboring gene intraflagellar transport 20 Neighboring gene TNF alpha induced protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26671214-26671717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:26672221-26672724 Neighboring gene uncharacterized LOC124903963 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:26683953-26684715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11924 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene SEBOX homeobox

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp586F1524

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in error-free translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in error-free translesion synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrial nucleoid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    polymerase delta-interacting protein 2
    Names
    38 kDa DNA polymerase delta interaction protein
    polymerase (DNA) delta interacting protein 2
    polymerase (DNA-directed), delta interacting protein 2
    polymerase delta interacting protein 38

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290145.2NP_001277074.1  polymerase delta-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001277074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC000655, BG150599, BM809398, HY130221
      Consensus CDS
      CCDS76978.1
      UniProtKB/TrEMBL
      A0A087WT81, B4DEM9
      Related
      ENSP00000477665.2, ENST00000618887.2
      Conserved Domains (2) summary
      cl01119
      Location:216337
      DUF525; Protein of unknown function (DUF525)
      cl01548
      Location:111182
      YccV-like; Hemimethylated DNA-binding protein YccV like
    2. NM_015584.5NP_056399.1  polymerase delta-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_056399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC000655, BG150599, BM809398, HY130221
      Consensus CDS
      CCDS74018.1
      UniProtKB/Swiss-Prot
      B2R846, Q96JE4, Q9Y2S7
      Related
      ENSP00000475924.2, ENST00000540200.6
      Conserved Domains (2) summary
      cl01119
      Location:234355
      DUF525; Protein of unknown function (DUF525)
      cl01548
      Location:74200
      YccV-like; Hemimethylated DNA-binding protein YccV like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      28346633..28357527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      29288484..29299376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)