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    HINFP histone H4 transcription factor [ Homo sapiens (human) ]

    Gene ID: 25988, updated on 4-Jul-2021

    Summary

    Official Symbol
    HINFPprovided by HGNC
    Official Full Name
    histone H4 transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:17850
    See related
    Ensembl:ENSG00000172273 MIM:607099
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIZF; HiNF-P; ZNF743
    Summary
    This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in testis (RPKM 6.2), lymph node (RPKM 4.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See HINFP in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119121577..119136059)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118992290..119006769)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984397 Neighboring gene C2CD2 like Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene NLR family member X1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp434F162

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H4 transcription factor
    Names
    MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
    MBD2-interacting zinc finger 1
    MBD2-interacting zinc finger protein
    histone H4 gene-specific protein HiNF-P
    histone nuclear factor P
    methyl-CpG-binding protein 2-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243259.2NP_001230188.1  histone H4 transcription factor isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS58188.1
      UniProtKB/Swiss-Prot
      Q9BQA5
      Related
      ENSP00000436815.1, ENST00000527410.3
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_001351957.2NP_001338886.1  histone H4 transcription factor isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      COG5236
      Location:194326
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:309329
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001351958.2NP_001338887.1  histone H4 transcription factor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, 6, and 7, encodes isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS8414.1
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    4. NM_001351959.2NP_001338888.1  histone H4 transcription factor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7, encodes isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS8414.1
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    5. NM_001351960.2NP_001338889.1  histone H4 transcription factor isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 2, 5, and 6, encodes isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS8414.1
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    6. NM_001351961.2NP_001338890.1  histone H4 transcription factor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes isoform 4.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    7. NM_001351962.2NP_001338891.1  histone H4 transcription factor isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes isoform 4.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. NM_001351963.2NP_001338892.1  histone H4 transcription factor isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      COG5236
      Location:2297
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:80100
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. NM_001351964.2NP_001338893.1  histone H4 transcription factor isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      COG5236
      Location:2297
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:80100
      ZF_C2H2; C2H2 Zn finger [structural motif]
    10. NM_001351965.2NP_001338894.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13, 14, 15, 16, and 17, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    11. NM_001351966.2NP_001338895.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12, 14, 15, 16, and 17, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    12. NM_001351969.2NP_001338898.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12, 13, 15, 16, and 17, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    13. NM_001351971.2NP_001338900.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 12, 13, 14, 16, and 17, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    14. NM_001351972.2NP_001338901.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 12, 13, 14, 15, and 17, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    15. NM_001351974.2NP_001338903.1  histone H4 transcription factor isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 12, 13, 14, 15, and 16, encodes isoform 6.
      Source sequence(s)
      AP002956, AP003391
      Conserved Domains (2) summary
      sd00017
      Location:3959
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1031
      ZF_C2H2; C2H2 Zn finger [structural motif]
    16. NM_015517.5NP_056332.2  histone H4 transcription factor isoform 1

      See identical proteins and their annotated locations for NP_056332.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 5, 6, and 7, encodes isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS8414.1
      UniProtKB/Swiss-Prot
      Q9BQA5
      UniProtKB/TrEMBL
      A0A024R3F5
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
    17. NM_198971.3NP_945322.1  histone H4 transcription factor isoform 1

      See identical proteins and their annotated locations for NP_945322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 5, 6, and 7, encodes isoform 1.
      Source sequence(s)
      AP002956, AP003391
      Consensus CDS
      CCDS8414.1
      UniProtKB/Swiss-Prot
      Q9BQA5
      UniProtKB/TrEMBL
      A0A024R3F5
      Related
      ENSP00000318085.3, ENST00000350777.7
      Conserved Domains (2) summary
      COG5236
      Location:171303
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      119121577..119136059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448430.1XP_024304198.1  histone H4 transcription factor isoform X3

      Conserved Domains (2) summary
      COG5236
      Location:2297
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:80100
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_011542744.2XP_011541046.1  histone H4 transcription factor isoform X1

      Conserved Domains (2) summary
      COG5236
      Location:185317
      COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      sd00017
      Location:300320
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. XM_017017499.1XP_016872988.1  histone H4 transcription factor isoform X2

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