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    ADGRA2 adhesion G protein-coupled receptor A2 [ Homo sapiens (human) ]

    Gene ID: 25960, updated on 17-Jun-2019

    Summary

    Official Symbol
    ADGRA2provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor A2provided by HGNC
    Primary source
    HGNC:HGNC:17849
    See related
    Ensembl:ENSG00000020181 MIM:606823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TEM5; GPR124
    Expression
    Broad expression in prostate (RPKM 39.9), fat (RPKM 36.6) and 23 other tissues See more
    Orthologs

    Genomic context

    See ADGRA2 in Genome Data Viewer
    Location:
    8p11.23
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (37796883..37844896)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37654401..37701504)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13802 Neighboring gene pyridoxal phosphate binding protein Neighboring gene uncharacterized LOC105379381 Neighboring gene VISTA enhancer hs1665 Neighboring gene BRF2 RNA polymerase III transcription initiation factor subunit Neighboring gene RAB11 family interacting protein 1 Neighboring gene RNA, 7SL, cytoplasmic 709, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
    NHGRI GWA Catalog
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ14390, KIAA1531, DKFZp434C211, DKFZp434J0911

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endothelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of establishment of blood-brain barrier ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    adhesion G protein-coupled receptor A2
    Names
    G-protein coupled receptor 124
    tumor endothelial marker 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032777.10NP_116166.9  adhesion G protein-coupled receptor A2 precursor

      See identical proteins and their annotated locations for NP_116166.9

      Status: VALIDATED

      Source sequence(s)
      AC130304, AC138356, AF378755, AI346793, AL110244, AY090637, DA569569
      Consensus CDS
      CCDS6097.2
      UniProtKB/Swiss-Prot
      Q96PE1
      UniProtKB/TrEMBL
      Q6YN44
      Related
      ENSP00000406367.2, ENST00000412232.2
      Conserved Domains (8) summary
      smart00082
      Location:192227
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:87190
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:86109
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:708752
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:88144
      LRR_8; Leucine rich repeat
      cl02422
      Location:351417
      HRM; Hormone receptor domain
      cl11960
      Location:257343
      Ig; Immunoglobulin domain
      cl21561
      Location:778946
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      37796883..37844896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544481.2XP_011542783.1  adhesion G protein-coupled receptor A2 isoform X1

      Conserved Domains (8) summary
      smart00082
      Location:192227
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:87190
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:86109
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:708752
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:88144
      LRR_8; Leucine rich repeat
      cl02422
      Location:351417
      HRM; Hormone receptor domain
      cl11960
      Location:257343
      Ig; Immunoglobulin domain
      cl21561
      Location:778969
      7tm_4; Olfactory receptor
    2. XM_011544483.2XP_011542785.1  adhesion G protein-coupled receptor A2 isoform X3

      See identical proteins and their annotated locations for XP_011542785.1

      UniProtKB/TrEMBL
      D3DSW5
      Conserved Domains (8) summary
      smart00082
      Location:192227
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:87190
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:86109
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:708752
      GPS; GPCR proteolysis site, GPS, motif
      pfam13855
      Location:88144
      LRR_8; Leucine rich repeat
      cl02422
      Location:351417
      HRM; Hormone receptor domain
      cl11960
      Location:257343
      Ig; Immunoglobulin domain
      cl21561
      Location:778916
      7tm_4; Olfactory receptor
    3. XM_011544482.2XP_011542784.1  adhesion G protein-coupled receptor A2 isoform X2

      Conserved Domains (8) summary
      smart00082
      Location:168203
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:88109
      LRR_1; leucine-rich repeat [structural motif]
      pfam01825
      Location:684728
      GPS; GPCR proteolysis site, GPS, motif
      pfam12799
      Location:110149
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:88142
      LRR_8; Leucine rich repeat
      cl02422
      Location:327393
      HRM; Hormone receptor domain
      cl11960
      Location:233319
      Ig; Immunoglobulin domain
      cl21561
      Location:754945
      7tm_4; Olfactory receptor
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