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    MPC2 mitochondrial pyruvate carrier 2 [ Homo sapiens (human) ]

    Gene ID: 25874, updated on 27-Nov-2024

    Summary

    Official Symbol
    MPC2provided by HGNC
    Official Full Name
    mitochondrial pyruvate carrier 2provided by HGNC
    Primary source
    HGNC:HGNC:24515
    See related
    Ensembl:ENSG00000143158 MIM:614737; AllianceGenome:HGNC:24515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRP44; SLC54A2
    Summary
    Enables identical protein binding activity. Involved in mitochondrial pyruvate transmembrane transport. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney (RPKM 34.8), liver (RPKM 32.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPC2 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (167916675..167937072, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (167268139..167288538, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (167885913..167906310, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:167691547-167692047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167697263-167697762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2053 Neighboring gene myelin protein zero like 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:167739237-167739808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:167740743-167741244 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:167761820-167761968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1538 Neighboring gene adenylate cyclase 10 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167830579-167831095 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:167831096-167831613 Neighboring gene Sharpr-MPRA regulatory region 4419 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167882400-167883076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:167883077-167883753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2055 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1541 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:167956130-167957329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2056 Neighboring gene microRNA 1255b-2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:168025104-168025604 Neighboring gene GCSH pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC125752, MGC125753, DKFZp564B167

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pyruvate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of inner mitochondrial membrane protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 

    General protein information

    Preferred Names
    mitochondrial pyruvate carrier 2
    Names
    brain protein 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143674.4NP_001137146.1  mitochondrial pyruvate carrier 2

      See identical proteins and their annotated locations for NP_001137146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL035304, KF455056, Z97876
      Consensus CDS
      CCDS1266.1
      UniProtKB/Swiss-Prot
      A8K261, O95563, Q3SXR6, Q6FIF3
      UniProtKB/TrEMBL
      B2R4Q7
      Related
      ENSP00000271373.4, ENST00000271373.9
      Conserved Domains (1) summary
      pfam03650
      Location:27125
      MPC; Uncharacterized protein family (UPF0041)
    2. NM_015415.3NP_056230.1  mitochondrial pyruvate carrier 2

      See identical proteins and their annotated locations for NP_056230.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL554033, KF455056, Z97876
      Consensus CDS
      CCDS1266.1
      UniProtKB/Swiss-Prot
      A8K261, O95563, Q3SXR6, Q6FIF3
      UniProtKB/TrEMBL
      B2R4Q7
      Related
      ENSP00000356820.4, ENST00000367846.8
      Conserved Domains (1) summary
      pfam03650
      Location:27125
      MPC; Uncharacterized protein family (UPF0041)

    RNA

    1. NR_026550.3 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC104157, Z97876

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      167916675..167937072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711266.4XP_006711329.1  mitochondrial pyruvate carrier 2 isoform X1

      See identical proteins and their annotated locations for XP_006711329.1

      UniProtKB/Swiss-Prot
      A8K261, O95563, Q3SXR6, Q6FIF3
      UniProtKB/TrEMBL
      B2R4Q7
      Related
      ENSP00000392874.1, ENST00000458574.1
      Conserved Domains (1) summary
      pfam03650
      Location:27125
      MPC; Uncharacterized protein family (UPF0041)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      167268139..167288538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335856.1XP_054191831.1  mitochondrial pyruvate carrier 2 isoform X1

      UniProtKB/Swiss-Prot
      A8K261, O95563, Q3SXR6, Q6FIF3