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    PRKD2 protein kinase D2 [ Homo sapiens (human) ]

    Gene ID: 25865, updated on 9-Oct-2021

    Summary

    Official Symbol
    PRKD2provided by HGNC
    Official Full Name
    protein kinase D2provided by HGNC
    Primary source
    HGNC:HGNC:17293
    See related
    Ensembl:ENSG00000105287 MIM:607074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKD2; HSPC187; nPKC-D2
    Summary
    The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: PKD2 (GeneID: 5311) and PRKD2 (GeneID: 25865) share the PKD2 symbol/alias in common. PKD2 is a widely used alternative name for protein kinase D2 (PRKD2), which can be confused with the official symbol for PKD2/polycystin-2/polycystic kidney disease 2. [19 Jun 2018]
    Expression
    Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PRKD2 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46674316..46717114, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47177573..47220371, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 8 Neighboring gene dishevelled binding antagonist of beta catenin 3 Neighboring gene DACT3 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene uncharacterized LOC107987269 Neighboring gene microRNA 320e Neighboring gene striatin 4 Neighboring gene fukutin related protein Neighboring gene Sharpr-MPRA regulatory region 93 Neighboring gene solute carrier family 1 member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    GeneReviews: Not available
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein kinase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C activity TAS
    Traceable Author Statement
    more info
     
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endothelial tube morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of CREB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone deacetylase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein kinase D signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein kinase D signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase D2
    NP_001073349.1
    NP_001073350.1
    NP_001073351.1
    NP_057541.2
    XP_005258773.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079880.2NP_001073349.1  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_001073349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000393978.1, ENST00000433867.5
      Conserved Domains (4) summary
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20840
      Location:129201
      C1_PKD2_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
      cd20843
      Location:254331
      C1_PKD2_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
    2. NM_001079881.2NP_001073350.1  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_001073350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000470804.1, ENST00000595515.5
      Conserved Domains (4) summary
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20840
      Location:129201
      C1_PKD2_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
      cd20843
      Location:254331
      C1_PKD2_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
    3. NM_001079882.2NP_001073351.1  serine/threonine-protein kinase D2 isoform B

      See identical proteins and their annotated locations for NP_001073351.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (B) has a shorter N-terminus when compared to isoform A.
      Source sequence(s)
      AF309082, AL050147, DA475821
      Consensus CDS
      CCDS59401.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000472744.1, ENST00000600194.5
      Conserved Domains (5) summary
      smart00220
      Location:398650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:108157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:234354
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:390649
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cl00040
      Location:131
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    4. NM_016457.5NP_057541.2  serine/threonine-protein kinase D2 isoform A

      See identical proteins and their annotated locations for NP_057541.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same isoform (A).
      Source sequence(s)
      AC008635, AF309082, AL050147
      Consensus CDS
      CCDS12689.1
      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000291281.3, ENST00000291281.9
      Conserved Domains (4) summary
      cd01239
      Location:391511
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:547806
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20840
      Location:129201
      C1_PKD2_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins
      cd20843
      Location:254331
      C1_PKD2_rpt2; second protein kinase C conserved region 1 (C1 domain) found in protein kinase D2 (PKD2) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      46674316..46717114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258716.2XP_005258773.2  serine/threonine-protein kinase D2 isoform X1

      See identical proteins and their annotated locations for XP_005258773.2

      UniProtKB/Swiss-Prot
      Q9BZL6
      Related
      ENSP00000469106.1, ENST00000601806.5
      Conserved Domains (5) summary
      smart00220
      Location:398650
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:108157
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01239
      Location:234354
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:390649
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cl00040
      Location:131
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
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