Format

Send to:

Choose Destination
    • Showing Current items.

    MOB4 MOB family member 4, phocein [ Homo sapiens (human) ]

    Gene ID: 25843, updated on 22-Aug-2021

    Summary

    Official Symbol
    MOB4provided by HGNC
    Official Full Name
    MOB family member 4, phoceinprovided by HGNC
    Primary source
    HGNC:HGNC:17261
    See related
    Ensembl:ENSG00000115540 MIM:609361
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3
    Summary
    This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in adrenal (RPKM 20.9), esophagus (RPKM 14.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MOB4 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (197515554..197553699)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198380278..198418423)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene RNY5 pseudogene 2 Neighboring gene raftlin family member 2 Neighboring gene methionyl-tRNA synthetase 2, mitochondrial

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC12264

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    MOB-like protein phocein
    Names
    MOB1, Mps One Binder kinase activator-like 3
    Mps One Binder kinase activator-like 3
    class II mMOB1
    mob1 homolog 3
    phocein, Mob-like protein
    preimplantation protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100819.3NP_001094289.1  MOB-like protein phocein isoform 3

      See identical proteins and their annotated locations for NP_001094289.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC020550, AK297514, BC005237, CR736874
      Consensus CDS
      CCDS46480.1
      UniProtKB/Swiss-Prot
      Q9Y3A3
      Related
      ENSP00000405354.2, ENST00000448447.6
      Conserved Domains (1) summary
      pfam03637
      Location:32186
      Mob1_phocein; Mob1/phocein family
    2. NM_001204094.1NP_001191023.1  MOB-like protein phocein isoform 2

      See identical proteins and their annotated locations for NP_001191023.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC020550, AK292938, CR736874, DC375649
      Consensus CDS
      CCDS2322.1
      UniProtKB/Swiss-Prot
      Q9Y3A3
      Related
      ENSP00000387289.1, ENST00000409360.1
      Conserved Domains (1) summary
      pfam03637
      Location:21175
      Mob1_phocein; Mob1/phocein family
    3. NM_015387.5NP_056202.2  MOB-like protein phocein isoform 1

      See identical proteins and their annotated locations for NP_056202.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC020550, BC005237, CR736874
      Consensus CDS
      CCDS2321.1
      UniProtKB/Swiss-Prot
      Q9Y3A3
      UniProtKB/TrEMBL
      A0A024R3X9
      Related
      ENSP00000315702.4, ENST00000323303.9
      Conserved Domains (1) summary
      pfam03637
      Location:53207
      Mob1_phocein; Mob1/phocein family
    4. NM_199482.4NP_955776.1  MOB-like protein phocein isoform 2

      See identical proteins and their annotated locations for NP_955776.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon at its 5' end compared to variant 1, resulting in a different 5' UTR and translation initiation at a downstream start codon. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same isoform (2).
      Source sequence(s)
      AC020550, AF250319, AL080070, CR736874, DC298610
      Consensus CDS
      CCDS2322.1
      UniProtKB/Swiss-Prot
      Q9Y3A3
      Related
      ENSP00000233892.4, ENST00000233892.8
      Conserved Domains (1) summary
      pfam03637
      Location:21175
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      197515554..197553699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center