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    GAK cyclin G associated kinase [ Homo sapiens (human) ]

    Gene ID: 2580, updated on 22-Jun-2024

    Summary

    Official Symbol
    GAKprovided by HGNC
    Official Full Name
    cyclin G associated kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:4113
    See related
    Ensembl:ENSG00000178950 MIM:602052; AllianceGenome:HGNC:4113
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DNAJ26; DNAJC26
    Summary
    In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in testis (RPKM 16.1), colon (RPKM 15.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GAK in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (849277..932316, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (847030..930388, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (843065..926104, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:860125-861324 Neighboring gene uncharacterized LOC105374341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:872957-874156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:880593-881094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:881095-881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:905677-906582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:906583-907488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:938924-939517 Neighboring gene transmembrane protein 175 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:957241-957400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:961731-962444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:962445-963158 Neighboring gene uncharacterized LOC124900645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:963506-964024 Neighboring gene diacylglycerol kinase theta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
    EBI GWAS Catalog
    Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
    EBI GWAS Catalog
    Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
    EBI GWAS Catalog
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    EBI GWAS Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    EBI GWAS Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with cyclin G associated kinase (GAK) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16629, FLJ40395, MGC99654

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in Golgi to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in clathrin coat assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in clathrin coat disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endoplasmic reticulum organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of clathrin coat assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle uncoating ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cyclin-G-associated kinase
    Names
    auxilin-2
    dnaJ homolog subfamily C member 26
    NP_001305063.1
    NP_005246.2
    XP_005272325.1
    XP_005272327.1
    XP_011511727.1
    XP_011511728.1
    XP_011511729.1
    XP_011511730.1
    XP_011511731.1
    XP_011511732.1
    XP_011511733.1
    XP_011511734.1
    XP_011511736.1
    XP_016863480.1
    XP_016863481.1
    XP_016863482.1
    XP_016863483.1
    XP_047305958.1
    XP_047305959.1
    XP_047305960.1
    XP_047305961.1
    XP_047305962.1
    XP_047305963.1
    XP_047305964.1
    XP_047305966.1
    XP_047305967.1
    XP_047305968.1
    XP_047305969.1
    XP_047305970.1
    XP_047305971.1
    XP_047305972.1
    XP_047305974.1
    XP_047305975.1
    XP_047305976.1
    XP_047305977.1
    XP_047305978.1
    XP_047305979.1
    XP_047305980.1
    XP_047305981.1
    XP_047305982.1
    XP_047305984.1
    XP_047305985.1
    XP_047305986.1
    XP_047305987.1
    XP_047305988.1
    XP_047305989.1
    XP_047305990.1
    XP_047305991.1
    XP_054205549.1
    XP_054205550.1
    XP_054205551.1
    XP_054205552.1
    XP_054205553.1
    XP_054205554.1
    XP_054205555.1
    XP_054205556.1
    XP_054205557.1
    XP_054205558.1
    XP_054205559.1
    XP_054205560.1
    XP_054205561.1
    XP_054205562.1
    XP_054205563.1
    XP_054205564.1
    XP_054205565.1
    XP_054205566.1
    XP_054205567.1
    XP_054205568.1
    XP_054205569.1
    XP_054205570.1
    XP_054205571.1
    XP_054205572.1
    XP_054205573.1
    XP_054205574.1
    XP_054205575.1
    XP_054205576.1
    XP_054205577.1
    XP_054205578.1
    XP_054205579.1
    XP_054205580.1
    XP_054205581.1
    XP_054205582.1
    XP_054205583.1
    XP_054205584.1
    XP_054205585.1
    XP_054205586.1
    XP_054205587.1
    XP_054205588.1
    XP_054205589.1
    XP_054205590.1
    XP_054205591.1
    XP_054205592.1
    XP_054205593.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001318134.2NP_001305063.1  cyclin-G-associated kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks three consecutive exons in the 5' coding region but maintains the same reading frame as variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AA287110, AI138676, AK299554, BC000816, BC085005
      Consensus CDS
      CCDS82902.1
      UniProtKB/TrEMBL
      B4DS37
      Related
      ENSP00000421361.1, ENST00000511163.5
      Conserved Domains (4) summary
      cd06257
      Location:11811225
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:53230
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:491629
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:46241
      PKc_like; Protein Kinases, catalytic domain
    2. NM_005255.4NP_005246.2  cyclin-G-associated kinase isoform 1

      See identical proteins and their annotated locations for NP_005246.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA287110, AI138676, BC000816, D88435, DA680073
      Consensus CDS
      CCDS3340.1
      UniProtKB/Swiss-Prot
      O14976, Q5U4P5, Q9BVY6
      UniProtKB/TrEMBL
      B4DS37
      Related
      ENSP00000314499.4, ENST00000314167.9
      Conserved Domains (4) summary
      cd06257
      Location:12601304
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      849277..932316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047450032.1XP_047305988.1  cyclin-G-associated kinase isoform X41

      UniProtKB/TrEMBL
      B4DS37
    2. XM_047450022.1XP_047305978.1  cyclin-G-associated kinase isoform X32

      UniProtKB/TrEMBL
      B4DS37
    3. XM_047450019.1XP_047305975.1  cyclin-G-associated kinase isoform X28

      UniProtKB/TrEMBL
      B4DS37
    4. XM_017007992.2XP_016863481.1  cyclin-G-associated kinase isoform X17

      UniProtKB/TrEMBL
      B4DS37
    5. XM_047450028.1XP_047305984.1  cyclin-G-associated kinase isoform X37

      UniProtKB/TrEMBL
      B4DS37
    6. XM_047450024.1XP_047305980.1  cyclin-G-associated kinase isoform X34

      UniProtKB/TrEMBL
      B4DS37
    7. XM_047450025.1XP_047305981.1  cyclin-G-associated kinase isoform X35

      UniProtKB/TrEMBL
      B4DS37
    8. XM_047450031.1XP_047305987.1  cyclin-G-associated kinase isoform X40

      UniProtKB/TrEMBL
      B4DS37
    9. XM_047450015.1XP_047305971.1  cyclin-G-associated kinase isoform X24

      UniProtKB/TrEMBL
      B4DS37
    10. XM_047450004.1XP_047305960.1  cyclin-G-associated kinase isoform X12

      UniProtKB/TrEMBL
      B4DS37
    11. XM_047450021.1XP_047305977.1  cyclin-G-associated kinase isoform X31

      UniProtKB/TrEMBL
      B4DS37
    12. XM_047450029.1XP_047305985.1  cyclin-G-associated kinase isoform X38

      UniProtKB/TrEMBL
      B4DS37
    13. XM_011513430.2XP_011511732.1  cyclin-G-associated kinase isoform X8

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:12251269
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:53230
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:491629
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:46241
      PKc_like; Protein Kinases, catalytic domain
    14. XM_011513434.3XP_011511736.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:11681212
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1173
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:434572
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1184
      PKc_like; Protein Kinases, catalytic domain
    15. XM_047450030.1XP_047305986.1  cyclin-G-associated kinase isoform X39

      UniProtKB/TrEMBL
      Q59HA5
    16. XM_047450012.1XP_047305968.1  cyclin-G-associated kinase isoform X21

      UniProtKB/TrEMBL
      B4DS37
    17. XM_047450002.1XP_047305958.1  cyclin-G-associated kinase isoform X10

      UniProtKB/TrEMBL
      Q59HA5
    18. XM_047450010.1XP_047305966.1  cyclin-G-associated kinase isoform X18

      UniProtKB/TrEMBL
      B4DS37
    19. XM_017007991.2XP_016863480.1  cyclin-G-associated kinase isoform X7

      UniProtKB/TrEMBL
      B4DS37
    20. XM_011513427.3XP_011511729.1  cyclin-G-associated kinase isoform X3

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:12741318
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41279
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:540678
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:39290
      PKc_like; Protein Kinases, catalytic domain
    21. XM_047450018.1XP_047305974.1  cyclin-G-associated kinase isoform X27

      UniProtKB/TrEMBL
      Q59HA5
    22. XM_047450026.1XP_047305982.1  cyclin-G-associated kinase isoform X36

      UniProtKB/TrEMBL
      Q59HA5
    23. XM_047450007.1XP_047305963.1  cyclin-G-associated kinase isoform X15

      UniProtKB/TrEMBL
      Q59HA5
    24. XM_047450014.1XP_047305970.1  cyclin-G-associated kinase isoform X23

      UniProtKB/TrEMBL
      B4DS37
    25. XM_047450023.1XP_047305979.1  cyclin-G-associated kinase isoform X33

      UniProtKB/TrEMBL
      B4DS37
    26. XM_047450005.1XP_047305961.1  cyclin-G-associated kinase isoform X13

      UniProtKB/TrEMBL
      B4DS37
    27. XM_011513428.3XP_011511730.1  cyclin-G-associated kinase isoform X4

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:12551299
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    28. XM_047450006.1XP_047305962.1  cyclin-G-associated kinase isoform X14

      UniProtKB/TrEMBL
      Q59HA5
    29. XM_047450013.1XP_047305969.1  cyclin-G-associated kinase isoform X22

      UniProtKB/TrEMBL
      Q59HA5
    30. XM_005272268.3XP_005272325.1  cyclin-G-associated kinase isoform X5

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:12491293
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    31. XM_011513426.3XP_011511728.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:12931337
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    32. XM_011513431.3XP_011511733.1  cyclin-G-associated kinase isoform X9

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:12211265
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    33. XM_005272270.3XP_005272327.1  cyclin-G-associated kinase isoform X20

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:11851229
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    34. XM_011513425.3XP_011511727.1  cyclin-G-associated kinase isoform X1

      UniProtKB/TrEMBL
      B4DS37
      Conserved Domains (4) summary
      cd06257
      Location:13041348
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:41309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14036
      Location:39320
      STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
      pfam10409
      Location:570708
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    35. XM_017007993.2XP_016863482.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:11681212
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1173
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:434572
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1184
      PKc_like; Protein Kinases, catalytic domain
    36. XM_011513432.3XP_011511734.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:12161260
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:1221
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:482620
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:1232
      PKc_like; Protein Kinases, catalytic domain
    37. XM_047450020.1XP_047305976.1  cyclin-G-associated kinase isoform X29

      UniProtKB/TrEMBL
      Q59HA5
    38. XM_047450003.1XP_047305959.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5
    39. XM_047450016.1XP_047305972.1  cyclin-G-associated kinase isoform X25

      UniProtKB/TrEMBL
      Q59HA5
    40. XM_011513429.3XP_011511731.1  cyclin-G-associated kinase isoform X6

      UniProtKB/TrEMBL
      Q59HA5
      Conserved Domains (4) summary
      cd06257
      Location:12421286
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      smart00220
      Location:24247
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam10409
      Location:508646
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein
      cl21453
      Location:25258
      PKc_like; Protein Kinases, catalytic domain
    41. XM_047450011.1XP_047305967.1  cyclin-G-associated kinase isoform X19

      UniProtKB/TrEMBL
      Q59HA5
    42. XM_047450008.1XP_047305964.1  cyclin-G-associated kinase isoform X16

      UniProtKB/TrEMBL
      Q59HA5
    43. XM_047450034.1XP_047305990.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5
    44. XM_047450035.1XP_047305991.1  cyclin-G-associated kinase isoform X43

      UniProtKB/TrEMBL
      Q59HA5
    45. XM_047450033.1XP_047305989.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5
    46. XM_017007994.2XP_016863483.1  cyclin-G-associated kinase isoform X30

      UniProtKB/TrEMBL
      B4DS37

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      847030..930388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349615.1XP_054205590.1  cyclin-G-associated kinase isoform X41

      UniProtKB/TrEMBL
      B4DS37
    2. XM_054349606.1XP_054205581.1  cyclin-G-associated kinase isoform X32

      UniProtKB/TrEMBL
      B4DS37
    3. XM_054349602.1XP_054205577.1  cyclin-G-associated kinase isoform X28

      UniProtKB/TrEMBL
      B4DS37
    4. XM_054349590.1XP_054205565.1  cyclin-G-associated kinase isoform X17

      UniProtKB/TrEMBL
      B4DS37
    5. XM_054349611.1XP_054205586.1  cyclin-G-associated kinase isoform X37

      UniProtKB/TrEMBL
      B4DS37
    6. XM_054349608.1XP_054205583.1  cyclin-G-associated kinase isoform X34

      UniProtKB/TrEMBL
      B4DS37
    7. XM_054349609.1XP_054205584.1  cyclin-G-associated kinase isoform X35

      UniProtKB/TrEMBL
      B4DS37
    8. XM_054349614.1XP_054205589.1  cyclin-G-associated kinase isoform X40

      UniProtKB/TrEMBL
      B4DS37
    9. XM_054349597.1XP_054205572.1  cyclin-G-associated kinase isoform X24

      UniProtKB/TrEMBL
      B4DS37
    10. XM_054349585.1XP_054205560.1  cyclin-G-associated kinase isoform X12

      UniProtKB/TrEMBL
      B4DS37
    11. XM_054349605.1XP_054205580.1  cyclin-G-associated kinase isoform X31

      UniProtKB/TrEMBL
      B4DS37
    12. XM_054349612.1XP_054205587.1  cyclin-G-associated kinase isoform X38

      UniProtKB/TrEMBL
      B4DS37
    13. XM_054349581.1XP_054205556.1  cyclin-G-associated kinase isoform X8

      UniProtKB/TrEMBL
      B4DS37
    14. XM_054349600.1XP_054205575.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
    15. XM_054349613.1XP_054205588.1  cyclin-G-associated kinase isoform X39

      UniProtKB/TrEMBL
      Q59HA5
    16. XM_054349594.1XP_054205569.1  cyclin-G-associated kinase isoform X21

      UniProtKB/TrEMBL
      B4DS37
    17. XM_054349583.1XP_054205558.1  cyclin-G-associated kinase isoform X10

      UniProtKB/TrEMBL
      Q59HA5
    18. XM_054349591.1XP_054205566.1  cyclin-G-associated kinase isoform X18

      UniProtKB/TrEMBL
      B4DS37
    19. XM_054349580.1XP_054205555.1  cyclin-G-associated kinase isoform X7

      UniProtKB/TrEMBL
      B4DS37
    20. XM_054349576.1XP_054205551.1  cyclin-G-associated kinase isoform X3

      UniProtKB/TrEMBL
      B4DS37
    21. XM_054349601.1XP_054205576.1  cyclin-G-associated kinase isoform X27

      UniProtKB/TrEMBL
      Q59HA5
    22. XM_054349610.1XP_054205585.1  cyclin-G-associated kinase isoform X36

      UniProtKB/TrEMBL
      Q59HA5
    23. XM_054349588.1XP_054205563.1  cyclin-G-associated kinase isoform X15

      UniProtKB/TrEMBL
      Q59HA5
    24. XM_054349596.1XP_054205571.1  cyclin-G-associated kinase isoform X23

      UniProtKB/TrEMBL
      B4DS37
    25. XM_054349607.1XP_054205582.1  cyclin-G-associated kinase isoform X33

      UniProtKB/TrEMBL
      B4DS37
    26. XM_054349586.1XP_054205561.1  cyclin-G-associated kinase isoform X13

      UniProtKB/TrEMBL
      B4DS37
    27. XM_054349577.1XP_054205552.1  cyclin-G-associated kinase isoform X4

      UniProtKB/TrEMBL
      B4DS37
    28. XM_054349587.1XP_054205562.1  cyclin-G-associated kinase isoform X14

      UniProtKB/TrEMBL
      Q59HA5
    29. XM_054349595.1XP_054205570.1  cyclin-G-associated kinase isoform X22

      UniProtKB/TrEMBL
      Q59HA5
    30. XM_054349578.1XP_054205553.1  cyclin-G-associated kinase isoform X5

      UniProtKB/TrEMBL
      Q59HA5
    31. XM_054349575.1XP_054205550.1  cyclin-G-associated kinase isoform X2

      UniProtKB/TrEMBL
      Q59HA5
    32. XM_054349582.1XP_054205557.1  cyclin-G-associated kinase isoform X9

      UniProtKB/TrEMBL
      B4DS37
    33. XM_054349593.1XP_054205568.1  cyclin-G-associated kinase isoform X20

      UniProtKB/TrEMBL
      B4DS37
    34. XM_054349574.1XP_054205549.1  cyclin-G-associated kinase isoform X1

      UniProtKB/TrEMBL
      B4DS37
    35. XM_054349599.1XP_054205574.1  cyclin-G-associated kinase isoform X26

      UniProtKB/TrEMBL
      Q59HA5
    36. XM_054349584.1XP_054205559.1  cyclin-G-associated kinase isoform X11

      UniProtKB/TrEMBL
      Q59HA5
    37. XM_054349603.1XP_054205578.1  cyclin-G-associated kinase isoform X29

      UniProtKB/TrEMBL
      Q59HA5
    38. XM_054349598.1XP_054205573.1  cyclin-G-associated kinase isoform X25

      UniProtKB/TrEMBL
      Q59HA5
    39. XM_054349579.1XP_054205554.1  cyclin-G-associated kinase isoform X6

      UniProtKB/TrEMBL
      Q59HA5
    40. XM_054349592.1XP_054205567.1  cyclin-G-associated kinase isoform X19

      UniProtKB/TrEMBL
      Q59HA5
    41. XM_054349589.1XP_054205564.1  cyclin-G-associated kinase isoform X16

      UniProtKB/TrEMBL
      Q59HA5
    42. XM_054349617.1XP_054205592.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5
    43. XM_054349618.1XP_054205593.1  cyclin-G-associated kinase isoform X43

      UniProtKB/TrEMBL
      Q59HA5
    44. XM_054349616.1XP_054205591.1  cyclin-G-associated kinase isoform X42

      UniProtKB/TrEMBL
      Q59HA5
    45. XM_054349604.1XP_054205579.1  cyclin-G-associated kinase isoform X30

      UniProtKB/TrEMBL
      B4DS37

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001286833.1: Suppressed sequence

      Description
      NM_001286833.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.