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    TAC4 tachykinin precursor 4 [ Homo sapiens (human) ]

    Gene ID: 255061, updated on 19-Sep-2024

    Summary

    Official Symbol
    TAC4provided by HGNC
    Official Full Name
    tachykinin precursor 4provided by HGNC
    Primary source
    HGNC:HGNC:16641
    See related
    Ensembl:ENSG00000176358 MIM:607833; AllianceGenome:HGNC:16641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EK; HK1; HK-1; PPT-C
    Summary
    This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See TAC4 in Genome Data Viewer
    Location:
    17q21.33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49838300..49848069, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50701401..50711169, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47915662..47925431, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47796530-47797090 Neighboring gene family with sequence similarity 117 member A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12370 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8675 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47865191-47865964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47879701-47880202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:47880203-47880702 Neighboring gene SRP14 pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:47893039-47894031 Neighboring gene lysine acetyltransferase 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:47911219-47911431 Neighboring gene uncharacterized LOC729220 Neighboring gene CRISPRi-validated cis-regulatory element chr17.3537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47938611-47939558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47941593-47942092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47942923-47943617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47948287-47949230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967128-47967965 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47967966-47968802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47976271-47977012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47980751-47981252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47986569-47987069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47990385-47990940 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:47991434-47992633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:47993407-47993919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:48001781-48002290 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:48005674-48006873 Neighboring gene MPRA-validated peak2887 silencer Neighboring gene MRT4 homolog, ribosome maturation factor pseudogene Neighboring gene RNA, U6 small nuclear 1313, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133009, MGC133010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables substance K receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables substance P receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables substance P receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tachykinin-4
    Names
    endokinin
    preprotachykinin-C
    tachykinin 4 (hemokinin)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029377.2 RefSeqGene

      Range
      5000..14769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077503.2NP_001070971.1  tachykinin-4 isoform beta precursor

      See identical proteins and their annotated locations for NP_001070971.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform beta) is shorter than isoform alpha.
      Source sequence(s)
      AC027801
      Consensus CDS
      CCDS42359.1
      UniProtKB/Swiss-Prot
      Q86UU9
      Related
      ENSP00000381221.1, ENST00000398154.5
    2. NM_001077504.2NP_001070972.1  tachykinin-4 isoform gamma precursor

      See identical proteins and their annotated locations for NP_001070972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma) uses an alternate in-frame splice site in the 5' coding region and skips an alternate in-frame exon in the 3' coding region, compared to variant alpha. The resulting protein (isoform gamma) is shorter than isoform alpha.
      Source sequence(s)
      AC027801
      Consensus CDS
      CCDS42360.1
      UniProtKB/Swiss-Prot
      Q86UU9
      Related
      ENSP00000325286.5, ENST00000326219.5
    3. NM_001077505.2NP_001070973.1  tachykinin-4 isoform delta precursor

      See identical proteins and their annotated locations for NP_001070973.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (delta) uses an alternate in-frame splice site in the 5' coding region and skips two alternate in-frame exons in the 3' coding region, compared to variant alpha. The resulting protein (isoform delta) is shorter than isoform alpha.
      Source sequence(s)
      AC027801
      Consensus CDS
      CCDS42358.1
      UniProtKB/Swiss-Prot
      Q86UU9
      Related
      ENSP00000340461.2, ENST00000352793.6
    4. NM_001077506.2NP_001070974.1  tachykinin-4 isoform alpha-2 precursor

      See identical proteins and their annotated locations for NP_001070974.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha-2) uses an alternate in-frame splice site in the 5' coding region, compared to variant alpha. The resulting protein (isoform alpha-2) is shorter than isoform alpha.
      Source sequence(s)
      AC027801
      Consensus CDS
      CCDS45727.1
      UniProtKB/Swiss-Prot
      Q86UU9
      Related
      ENSP00000399702.1, ENST00000436235.6
    5. NM_170685.3NP_733786.2  tachykinin-4 isoform alpha precursor

      See identical proteins and their annotated locations for NP_733786.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha).
      Source sequence(s)
      AC027801
      Consensus CDS
      CCDS42357.1
      UniProtKB/Swiss-Prot
      Q2M2P1, Q6ECK8, Q86UU6, Q86UU7, Q86UU8, Q86UU9, Q8IWZ7
      Related
      ENSP00000334042.4, ENST00000334568.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      49838300..49848069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      50701401..50711169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)