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    RICTOR RPTOR independent companion of MTOR complex 2 [ Homo sapiens (human) ]

    Gene ID: 253260, updated on 12-Oct-2019

    Summary

    Official Symbol
    RICTORprovided by HGNC
    Official Full Name
    RPTOR independent companion of MTOR complex 2provided by HGNC
    Primary source
    HGNC:HGNC:28611
    See related
    Ensembl:ENSG00000164327 MIM:609022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIA; AVO3; hAVO3
    Summary
    RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues See more
    Orthologs

    Genomic context

    See RICTOR in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (38937920..39074421, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38938022..39074505, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OSMR antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105374733 Neighboring gene uncharacterized LOC112267930 Neighboring gene oncostatin M receptor Neighboring gene androgen induced 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14991 Neighboring gene FYN binding protein 1 Neighboring gene golgin A5 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
      Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
      CD28 dependent PI3K/Akt signaling, organism-specific biosystemPI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific role...
    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Constitutive Signaling by AKT1 E17K in Cancer, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by AKT1 E17K in Cancer, organism-specific biosystemWhile AKT1 gene copy number, expression level and phosphorylation are often increased in cancer, only one low frequency point mutation has been repeatedly reported in cancer and functionally studied....
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Oncostatin M Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Oncostatin M Signaling Pathway, organism-specific biosystemOncostatin M (OSM) is a member of the multifunctional cytokine interleukin 6 (IL6) - type cytokine family. It is mainly produced in cell types such as activated T lymphocytes, macrophages, monocytes,...
    • PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystem (from WikiPathways)
      PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, organism-specific biosystemThis pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resis...
    • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
      PI3K/AKT Signaling in Cancer, organism-specific biosystemClass IA PI3K is a heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). In the absence of activating signa...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Degradation, organism-specific biosystemIn unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53...
    • Regulation of TP53 Expression and Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Expression and Degradation, organism-specific biosystemTP53 (p53) tumor suppressor protein is a transcription factor that functions as a homotetramer (Jeffrey et al. 1995). The protein levels of TP53 are low in unstressed cells due to MDM2-mediated ubiqu...
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
      Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1999, MGC39830, DKFZp686B11164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton reorganization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase B activity TAS
    Traceable Author Statement
    more info
     
    embryo development ending in birth or egg hatching ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment or maintenance of actin cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rapamycin-insensitive companion of mTOR
    Names
    AVO3 homolog
    TORC2-specific protein AVO3
    pianissimo

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285439.2NP_001272368.1  rapamycin-insensitive companion of mTOR isoform 2

      See identical proteins and their annotated locations for NP_001272368.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      Consensus CDS
      CCDS68861.1
      UniProtKB/Swiss-Prot
      Q6R327
      Related
      ENSP00000296782.5, ENST00000296782.9
      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    2. NM_001285440.2NP_001272369.1  rapamycin-insensitive companion of mTOR isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses in-frame acceptor splice sites at 2 internal exons compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      UniProtKB/Swiss-Prot
      Q6R327
      Conserved Domains (5) summary
      pfam14663
      Location:462568
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:3152
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:799903
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:240455
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:637704
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    3. NM_152756.5NP_689969.2  rapamycin-insensitive companion of mTOR isoform 1

      See identical proteins and their annotated locations for NP_689969.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      Consensus CDS
      CCDS34148.1
      UniProtKB/Swiss-Prot
      Q6R327
      Related
      ENSP00000349959.3, ENST00000357387.8
      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      38937920..39074421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714463.3XP_006714526.1  rapamycin-insensitive companion of mTOR isoform X5

      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    2. XM_011514005.2XP_011512307.1  rapamycin-insensitive companion of mTOR isoform X2

      Conserved Domains (5) summary
      pfam14663
      Location:747853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10841188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    3. XM_017009314.2XP_016864803.1  rapamycin-insensitive companion of mTOR isoform X7

      Conserved Domains (5) summary
      pfam14663
      Location:462568
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:3152
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:799903
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:240455
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:637704
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    4. XM_017009311.1XP_016864800.1  rapamycin-insensitive companion of mTOR isoform X1

    5. XM_017009313.1XP_016864802.1  rapamycin-insensitive companion of mTOR isoform X4

    6. XM_011514006.3XP_011512308.1  rapamycin-insensitive companion of mTOR isoform X6

      Conserved Domains (5) summary
      pfam14663
      Location:684790
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:2374
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:10211125
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:462677
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:859926
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    7. XM_017009315.2XP_016864804.1  rapamycin-insensitive companion of mTOR isoform X8

    8. XM_017009312.1XP_016864801.1  rapamycin-insensitive companion of mTOR isoform X3

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