Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnpprovided by RGD
Official Full Name: 2',3'-cyclic nucleotide 3' phosphodiesteraseprovided by RGD
Primary source: RGD:2368
See related: Ensembl:ENSRNOG00000017496 AllianceGenome:RGD:2368
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CNPF; CNPI; Cnp1; CNPII
Summary: Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity and cyclic nucleotide binding activity. Involved in forebrain development; regulation of mitochondrial membrane permeability; and response to lipopolysaccharide. Located in several cellular components, including mitochondrial membrane; myelin sheath abaxonal region; and myelin sheath adaxonal region. Used to study carotid stenosis. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Orthologous to human CNP (2',3'-cyclic nucleotide 3' phosphodiesterase). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Brain (RPKM 1563.2), Spleen (RPKM 490.2) and 6 other tissues See more
Orthologs: all
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Genomic context

Location:: 10q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86011504..86018063)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85511164..85517723)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility.
Title: Sirt3 increases CNPase enzymatic activity through deacetylation and facilitating substrate accessibility.
All pups with exposure to methadone demonstrated decreased expression of CNP in the cerebral cortex and hippocampus.In the cerebellum, PLP expression was downregulated without apparent alteration of CNP and MBP expression. PLP and MBP expression, but not CNP expression, were significantly inhibited in the brainstem.
Title: Diverse changes in myelin protein expression in rat brain after perinatal methadone exposure.
the role of CNPase, serine/threonine kinases, and MEL in the mPTP opening was examined.
Title: Possible Involvement of 2',3'-Cyclic Nucleotide-3'-Phosphodiesterase in the Protein Phosphorylation-Mediated Regulation of the Permeability Transition Pore.
Perinatal methylmercury exposure reduces the expression of Plp1 and Cnp splice variants in cerebellum of rat pups.
Title: Perinatal methylmercury exposure perturbs the expression of Plp1 and Cnp splice variants in cerebellum of rat pups.
In non-synaptic mitochondria from old rats, the CNP level was decreased by 34%.
Title: In aging, the vulnerability of rat brain mitochondria is enhanced due to reduced level of 2',3'-cyclic nucleotide-3'-phosphodiesterase (CNP) and subsequently increased permeability transition in brain mitochondria in old animals.
kidneys express 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase), and renal CNPase mediates in part the renal 2',3'-cAMP-adenosine pathway
Title: Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway.
CNPase expression was induced in the course of restoration following HCP-induced insults to oligodendroglia and the myelin sheath.
Title: Hexachlorophene and cuprizone induce the spongy change of the developing rat brain by different mechanisms: the role of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase).
The environmental enrichment-induced increases in the total number of CNPase positive cells in the corpus callosum of middle-aged rats.
Title: Enriched environment increases the total number of CNPase positive cells in the corpus callosum of middle-aged rats.
The reduction in CNPase expression may contribute to the changes in the myelin morphology observed in aniline intoxication.
Title: Activity of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in spinal cord with spongy change induced by a single oral dose of aniline in rats.
results show that CNP is an RNA-binding protein and suggest that CNP1 may regulate expression of mRNAs in oligodendrocytes of the central nervous system
Title: 2',3'-Cyclic nucleotide 3'-phosphodiesterase: a novel RNA-binding protein that inhibits protein synthesis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127905 (e-PCR)
- UniSTS:211215

RH94388 (e-PCR)
- UniSTS:119636

RH129321 (e-PCR)
- UniSTS:212628

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity	TAS Traceable Author Statement more info	PubMed
enables cyclic nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cyclic nucleotide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cyclic nucleotide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in forebrain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in myelin maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to toxic substance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin filament	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in filopodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath adaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 2',3'-cyclic-nucleotide 3'-phosphodiesterase

Names: CNPase

NP_036941.1

EC 3.1.4.37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012809.2 → NP_036941.1 2',3'-cyclic-nucleotide 3'-phosphodiesterase

See identical proteins and their annotated locations for NP_036941.1

Status: PROVISIONAL

Source sequence(s)

BC098066

UniProtKB/Swiss-Prot

P13233, Q4V796, Q64575

UniProtKB/TrEMBL

A0ACJ1MT34

Related

ENSRNOP00000080276.2, ENSRNOT00000103289.2

Conserved Domains (3) summary

pfam05881
Location:186 → 398

CNPase; 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase)

pfam13671
Location:52 → 165

AAA_33; AAA domain

cl17190
Location:51 → 176

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...