Avpr2 arginine vasopressin receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Avpr2provided by RGD
Official Full Name: arginine vasopressin receptor 2provided by RGD
Primary source: RGD:2186
See related: Ensembl:ENSRNOG00000059862 AllianceGenome:RGD:2186
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable peptide binding activity and vasopressin receptor activity. Involved in several processes, including negative regulation of renal sodium excretion; negative regulation of urine volume; and positive regulation of systemic arterial blood pressure. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Used to study hypertension. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. Orthologous to human AVPR2 (arginine vasopressin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 45.6), Thymus (RPKM 40.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (156785009..156787477)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (151633501..151636155)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156889006..156892707, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type2 receptor upregulation.
Title: Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type‑2 receptor upregulation.
Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness.
Title: Inner Ear Arginine Vasopressin-Vasopressin Receptor 2-Aquaporin 2 Signaling Pathway Is Involved in the Induction of Motion Sickness.
Periconceptional ethanol exposure induces a sex specific diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring.
Title: Periconceptional ethanol exposure induces a sex specific diuresis and increase in AQP2 and AVPR2 in the kidneys of aged rat offspring.
Site-1 protease-derived (S1P-derived) soluble (pro)renin receptor (sPRR) participates in regulation of fluid homeostasis via targeting V2R. In cultured rat inner medullary collecting duct (IMCD) cells, AVP-induced V2R expression was blunted by a PRR antagonist, PRO20; a PRR-neutralizing antibody; or a S1P inhibitor, PF-429242. In parallel, sPRR release was increased by AVP and reduced by PF-429242.
Title: Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability.
Chronic vasopressin V2R antagonism may contribute to the worsening of PAH and the development of RV remodeling.
Title: Detrimental Impact of Vasopressin V2 Receptor Antagonism in a SU5416/Hypoxia/Normoxia-Exposed Rat Model of Pulmonary Arterial Hypertension.
The combination of V1aR and V2R antagonists prevented cardiac/renal damage in rat model of hypertensive heart failure.
Title: Effects of Long-term Blockade of Vasopressin Receptor Types 1a and 2 on Cardiac and Renal Damage in a Rat Model of Hypertensive Heart Failure.
Regulation of V2 receptor by vasopressin
Title: Regulation of V2 receptor by vasopressin is different in Brattleboro rats compared with Wistar.
Data suggest that vasopressin receptors V1b (Avpr1b) and V2 (Avpr2) in neurons of cerebral ventricles mediate stress-induced baroreflex desensitization enabling concurrent hypertension and tachycardia.
Title: Evidence for involvement of central vasopressin V1b and V2 receptors in stress-induced baroreflex desensitization.
the presence of an increased AVP sensitivity in the CDs from CHF rats, associated with an acquired recycling ability of the V2 receptor
Title: Congestive heart failure in rats is associated with increased collecting duct vasopressin sensitivity and vasopressin type 2 receptor reexternalization.
There was no change in V receptor expression during the development of hypertension.
Title: Age-dependent regulation of renal vasopressin V(1A) and V₂ receptors in rats with genetic hypertension: implications for the treatment of hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (37)

General gene information

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Markers

RH127646 (e-PCR)
- UniSTS:210956

REN88106 (e-PCR)
- UniSTS:412904

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	TAS Traceable Author Statement more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info
enables vasopressin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V2 receptor

Names: AVPR V2; V2R; Vasopressin receptor V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.