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    Esr1 estrogen receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24890, updated on 18-Apr-2019

    Summary

    Official Symbol
    Esr1provided by RGD
    Official Full Name
    estrogen receptor 1provided by RGD
    Primary source
    RGD:2581
    See related
    Ensembl:ENSRNOG00000019358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Esr; ER-alpha; RNESTROR
    Summary
    acts as a transcriptional activator when bound to estrogen; may play a role in myocardial regulation [RGD, Feb 2006]
    Annotation information
    Annotation category: suggests misassembly
    Expression
    Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues See more
    Orthologs

    Genomic context

    See Esr1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41192029..41594799)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (42534049..42935434)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene nesprin-1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    TFIIB-class transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    TFIIB-class transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    estrogen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    estrogen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    estrogen receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    estrogen receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen response element binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    hormone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hormone binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    phosphatidylinositol 3-kinase regulatory subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    steroid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription coactivator binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    type 1 metabotropic glutamate receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Sertoli cell development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Sertoli cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    baculum development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to estradiol stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    decidualization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    epithelial cell proliferation involved in mammary gland duct elongation IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell proliferation involved in mammary gland duct elongation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular steroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mammary gland alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland alveolus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mammary gland branching involved in pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland branching involved in pregnancy ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of glucose import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of production of miRNAs involved in gene silencing by miRNA IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of production of miRNAs involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of triglyceride metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoblast development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    prostate epithelial cord elongation IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord elongation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein localization to chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of branching involved in prostate gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of branching involved in prostate gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    uterus development IEA
    Inferred from Electronic Annotation
    more info
     
    uterus development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vagina development IEA
    Inferred from Electronic Annotation
    more info
     
    vagina development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcriptionally active chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptionally active chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    estrogen receptor
    Names
    C-terminally-truncated estrogen receptor alpha product-1
    Er alpha
    estradiol receptor
    estrogen receptor 1 (alpha)
    estrogen receptor alpha c-terminus splice variant 1-2
    estrogen receptor alpha i45aL
    estrogen receptor alpha i45aS
    estrogen receptor alpha i45c
    estrogen receptor alpha i56a
    estrogen receptor alpha i56b
    estrogen receptor alpha i56c
    estrogen receptor alpha i56dL
    estrogen receptor alpha i56dS
    estrogen receptor alpha i56e
    estrogen receptor alpha variant delta 4
    estrogen receptor protein
    nuclear receptor subfamily 3 group A member 1
    truncated estrogen receptor product-2
    trunctaed estrogen receptor product-1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012689.1NP_036821.1  estrogen receptor

      See identical proteins and their annotated locations for NP_036821.1

      Status: PROVISIONAL

      Source sequence(s)
      Y00102
      UniProtKB/Swiss-Prot
      P06211
      Related
      ENSRNOP00000026350.7, ENSRNOT00000026350.7
      Conserved Domains (4) summary
      cd06949
      Location:315552
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:185266
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42186
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:561600
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      41192029..41594799
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588795.1XP_017444284.1  estrogen receptor isoform X1

      UniProtKB/TrEMBL
      D0FYH4
      Conserved Domains (4) summary
      cd06949
      Location:315552
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:185266
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42186
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:561600
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    2. XM_006227832.3XP_006227894.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_006227894.1

      UniProtKB/TrEMBL
      D0FYH4
      Conserved Domains (4) summary
      cd06949
      Location:315552
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:185266
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42186
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:561600
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    3. XM_008758704.2XP_008756926.1  estrogen receptor isoform X1

      See identical proteins and their annotated locations for XP_008756926.1

      UniProtKB/TrEMBL
      D0FYH4
      Conserved Domains (4) summary
      cd06949
      Location:315552
      NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
      cd07171
      Location:185266
      NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
      pfam02159
      Location:42186
      Oest_recep; Oestrogen receptor
      pfam12743
      Location:561600
      ESR1_C; Oestrogen-type nuclear receptor final C-terminal
    4. XM_017588797.1XP_017444286.1  estrogen receptor isoform X3

      UniProtKB/TrEMBL
      A0A0G2K0D4
      Related
      ENSRNOP00000071400.1, ENSRNOT00000078494.1
    5. XM_017588796.1XP_017444285.1  estrogen receptor isoform X2

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      36921417..37175762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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