U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Tacr3 tachykinin receptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24808, updated on 17-Aug-2024

    Summary

    Official Symbol
    Tacr3provided by RGD
    Official Full Name
    tachykinin receptor 3provided by RGD
    Primary source
    RGD:3810
    See related
    EnsemblRapid:ENSRNOG00000009372 AllianceGenome:RGD:3810
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nkr; Nmkr; Tac3r
    Summary
    Enables tachykinin receptor activity. Involved in several processes, including hyperosmotic salinity response; positive regulation of uterine smooth muscle contraction; and response to alkaloid. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and nucleus. Used to study hypertension. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 30.9), Kidney (RPKM 7.7) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tacr3 in Genome Data Viewer
    Location:
    2q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (225940497..226037756)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223266536..223363791)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240021152..240118971)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene uncharacterized LOC134485768 Neighboring gene uncharacterized LOC134485806 Neighboring gene 40S ribosomal protein S26-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tachykinin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tachykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuromedin-K receptor
    Names
    NK-3 receptor
    NK-3R
    Neuromedin K receptor (Neurokinin B/Tachikin 3)
    neurokinin B receptor
    tachikin receptor 3
    NP_058749.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017053.1NP_058749.1  neuromedin-K receptor

      See identical proteins and their annotated locations for NP_058749.1

      Status: PROVISIONAL

      Source sequence(s)
      J05189
      UniProtKB/Swiss-Prot
      P16177
      UniProtKB/TrEMBL
      A6HVV9
      Related
      ENSRNOP00000012473.2, ENSRNOT00000012473.4
      Conserved Domains (2) summary
      pfam00001
      Location:89343
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:81204
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      225940497..226037756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)