Format

Send to:

Choose Destination
    • Showing Current items.

    Adipoq adiponectin, C1Q and collagen domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246253, updated on 13-Jan-2019

    Summary

    Official Symbol
    Adipoqprovided by RGD
    Official Full Name
    adiponectin, C1Q and collagen domain containingprovided by RGD
    Primary source
    RGD:628748
    See related
    Ensembl:ENSRNOG00000001821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acdc; Adid; Acrp30
    Summary
    adipocyte complement-related factor that plays a role in obesity-related insulin resistance [RGD, Feb 2006]
    Expression
    Biased expression in Adrenal (RPKM 1195.4), Thymus (RPKM 913.1) and 5 other tissues See more
    Orthologs

    Genomic context

    See Adipoq in Genome Data Viewer
    Location:
    11q23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (81330845..81344488, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (84363940..84382663, complement)

    Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Neighboring gene uncharacterized LOC108352356 Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene replication factor C subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
      AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • AMPK signaling pathway, organism-specific biosystem (from KEGG)
      AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • AMPK signaling pathway, conserved biosystem (from KEGG)
      AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
      Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
      Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
      Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Longevity regulating pathway, organism-specific biosystem (from KEGG)
      Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • PPAR signaling pathway, organism-specific biosystem (from KEGG)
      PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • PPAR signaling pathway, conserved biosystem (from KEGG)
      PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sialic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sialic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    signaling receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to epinephrine stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    detection of oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    detection of oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    fatty acid oxidation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of granulocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of low-density lipoprotein particle receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of low-density lipoprotein particle receptor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage derived foam cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of metanephric mesenchymal cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of metanephric mesenchymal cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor-alpha signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular associated smooth muscle cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glycogen (starch) synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-8 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of metanephric glomerular visceral epithelial cell development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of metanephric glomerular visceral epithelial cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotactic protein-1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase A signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase A signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of renal albumin absorption ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal albumin absorption ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein heterotrimerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to linoleic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to sucrose IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    response to tumor necrosis factor ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell periphery ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adiponectin
    Names
    adipocyte complement related protein of 30 kDa
    adiponectin d

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144744.3NP_653345.1  adiponectin precursor

      See identical proteins and their annotated locations for NP_653345.1

      Status: VALIDATED

      Source sequence(s)
      AC120949, FM047633
      UniProtKB/TrEMBL
      Q8K3R4
      Related
      ENSRNOP00000002492.3, ENSRNOT00000002492.5
      Conserved Domains (2) summary
      smart00110
      Location:109242
      C1Q; Complement component C1q domain
      pfam01391
      Location:42107
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

      Range
      81330845..81344488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000079.1 Alternate Rn_Celera

      Range
      76596543..76599824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center