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    GAS2L2 growth arrest specific 2 like 2 [ Homo sapiens (human) ]

    Gene ID: 246176, updated on 5-Mar-2024

    Summary

    Official Symbol
    GAS2L2provided by HGNC
    Official Full Name
    growth arrest specific 2 like 2provided by HGNC
    Primary source
    HGNC:HGNC:24846
    See related
    Ensembl:ENSG00000270765 MIM:611398; AllianceGenome:HGNC:24846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAR17; CILD41
    Summary
    The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]
    Expression
    Biased expression in lung (RPKM 1.4), fat (RPKM 0.6) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GAS2L2 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35744511..35753239, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36692448..36701176, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34071530..34080258, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 2 subunit beta 1 Neighboring gene Sharpr-MPRA regulatory region 1039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34059551-34060074 Neighboring gene ribosomal protein L17 pseudogene 42 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12079 Neighboring gene RAS like family 10 member B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34092667-34093167 Neighboring gene chromosome 17 open reading frame 50 Neighboring gene matrix metallopeptidase 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34121971-34122509 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34136503-34137204 Neighboring gene TATA-box binding protein associated factor 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal anchor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with ciliary basal body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with microtubule plus-end IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    GAS2-like protein 2
    Names
    GAS2-related protein on chromosome 17

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029638.1 RefSeqGene

      Range
      4640..13368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139285.4NP_644814.1  GAS2-like protein 2

      See identical proteins and their annotated locations for NP_644814.1

      Status: REVIEWED

      Source sequence(s)
      AC006237
      Consensus CDS
      CCDS11298.1
      UniProtKB/Swiss-Prot
      Q8NHY3, Q8NHY4
      Related
      ENSP00000474529.2, ENST00000604641.6
      Conserved Domains (2) summary
      cd00014
      Location:34159
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam02187
      Location:207274
      GAS2; Growth-Arrest-Specific Protein 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      35744511..35753239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      36692448..36701176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)