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    EML2 EMAP like 2 [ Homo sapiens (human) ]

    Gene ID: 24139, updated on 17-Sep-2024

    Summary

    Official Symbol
    EML2provided by HGNC
    Official Full Name
    EMAP like 2provided by HGNC
    Primary source
    HGNC:HGNC:18035
    See related
    Ensembl:ENSG00000125746 MIM:617494; AllianceGenome:HGNC:18035
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ELP70; EMAP2; EMAP-2
    Summary
    Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Colocalizes with mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in esophagus (RPKM 8.7), skin (RPKM 8.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EML2 in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45609400..45645629, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48436666..48472895, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46112658..46148887, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46056279-46056909 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46056910-46057539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46061287-46061787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46065110-46065908 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46066707-46067504 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:46067505-46068302 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:46080520-46081155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46084233-46084733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46085233-46086168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46086169-46087104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46100634-46101271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46101272-46101908 Neighboring gene G protein-coupled receptor 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46119367-46120205 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46120206-46121043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46130698-46131198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46141481-46142332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46142333-46143184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14803 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46145740-46146591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14808 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46148647-46149146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10786 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:46150807-46151667 Neighboring gene EML2 antisense RNA 1 Neighboring gene microRNA 330 Neighboring gene RNA, 7SL, cytoplasmic 836, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46173596-46174114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46174115-46174633 Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 642a Neighboring gene microRNA 642b

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The interaction of CXCR4 with HIV-1 gp120 mediates gp120-induced upregulation of the CXCR3 and EMAP2 expression in human lung microvascular endothelial cells PubMed
    env HIV-1 gp120-induced upregulation of CXCR3 and EMAP2 expression and apoptosis requires activation of p38 MAPK in human lung microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    colocalizes_with mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    echinoderm microtubule-associated protein-like 2
    Names
    echinoderm MT-associated protein (EMAP)-like protein 70
    echinoderm microtubule associated protein like 2
    microtubule-associated protein like echinoderm EMAP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193268.3NP_001180197.1  echinoderm microtubule-associated protein-like 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC006132, AC011480, AK296258
      Consensus CDS
      CCDS59399.1
      UniProtKB/TrEMBL
      B7Z2F5
      Related
      ENSP00000468312.1, ENST00000587152.6
      Conserved Domains (4) summary
      COG2319
      Location:277698
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:220292
      HELP; HELP motif
      sd00039
      Location:627659
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:539848
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001193269.2NP_001180198.1  echinoderm microtubule-associated protein-like 2 isoform 3

      See identical proteins and their annotated locations for NP_001180198.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region which results in the use of a different start codon, compared to variant 1, and an isoform (3) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC006132, AF103939, AK295905
      Consensus CDS
      CCDS54280.1
      UniProtKB/TrEMBL
      B7Z2F5
      Related
      ENSP00000442365.1, ENST00000536630.5
      Conserved Domains (4) summary
      COG2319
      Location:223644
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:166238
      HELP; HELP motif
      sd00039
      Location:573605
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:485794
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001352051.2NP_001338980.1  echinoderm microtubule-associated protein-like 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AF103939, AK026616, DC366776
      Conserved Domains (2) summary
      COG2319
      Location:63485
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:310342
      7WD40; WD40 repeat [structural motif]
    4. NM_001352052.1NP_001338981.1  echinoderm microtubule-associated protein-like 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AF103939, AK295905, DC316305, DC317883
      UniProtKB/TrEMBL
      B7Z2F5
      Conserved Domains (4) summary
      COG2319
      Location:276697
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:626658
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:219291
      HELP; HELP motif
      cl25676
      Location:655746
      WD40_4; Type of WD40 repeat
    5. NM_001352053.2NP_001338982.1  echinoderm microtubule-associated protein-like 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC006132, AF103939, AK295905, DA395373
      UniProtKB/TrEMBL
      B7Z2F5
      Conserved Domains (4) summary
      COG2319
      Location:222643
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:572604
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:165237
      HELP; HELP motif
      cl25676
      Location:601692
      WD40_4; Type of WD40 repeat
    6. NM_001352054.2NP_001338983.1  echinoderm microtubule-associated protein-like 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AF103939, AK296258, DA252154
      Conserved Domains (4) summary
      COG2319
      Location:54475
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:404436
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:169
      HELP; HELP motif
      cl25676
      Location:433524
      WD40_4; Type of WD40 repeat
    7. NM_012155.4NP_036287.1  echinoderm microtubule-associated protein-like 2 isoform 2

      See identical proteins and their annotated locations for NP_036287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of a different start codon, compared to variant 1, and an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF103939
      Consensus CDS
      CCDS12670.1
      UniProtKB/Swiss-Prot
      B7Z3I2, B7Z3Q9, K7ERL7, O95834, Q59EN8, Q8N5A2, Q9UG50
      Related
      ENSP00000245925.3, ENST00000245925.8
      Conserved Domains (4) summary
      COG2319
      Location:76497
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:1991
      HELP; HELP motif
      sd00039
      Location:426458
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:338647
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_147899.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA352385, AF103939, AK296258, DC316305, DC317883
    2. NR_147900.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF103939, AK296258, BC029304
    3. NR_147901.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF103939, AK295905, DC316305, DC317883
    4. NR_147902.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA352385, AC006132, AF103939, AK295905, DA395373
    5. NR_147903.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006132, AF103939, AK295905, HY326766

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45609400..45645629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48436666..48472895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)