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    LDOC1 LDOC1 regulator of NFKB signaling [ Homo sapiens (human) ]

    Gene ID: 23641, updated on 8-Dec-2022

    Summary

    Official Symbol
    LDOC1provided by HGNC
    Official Full Name
    LDOC1 regulator of NFKB signalingprovided by HGNC
    Primary source
    HGNC:HGNC:6548
    See related
    Ensembl:ENSG00000182195 MIM:300402; AllianceGenome:HGNC:6548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mar7; RTL7; BCUR1; Mart7; SIRH7
    Summary
    The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See LDOC1 in Genome Data Viewer
    Location:
    Xq27.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (141173235..141177129, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (139490611..139494505, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140267420..140271314, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 3, pseudogene Neighboring gene RPL36A pseudogene 52 Neighboring gene SPANX family member C Neighboring gene RBMX2 pseudogene 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    • bG82i1.9,_DNA_segment_containing_(CA)_repeat (e-PCR)

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein LDOC1
    Names
    Sushi-Ichi retrotransposon homolog 7
    breast cancer, up-regulated 1
    leucine zipper down-regulated in cancer 1
    leucine zipper downregulated in cancer
    leucine zipper protein down-regulated in cancer cells
    mammalian retrotransposon-derived 7
    retrotransposon Gag like 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012317.4NP_036449.1  protein LDOC1

      See identical proteins and their annotated locations for NP_036449.1

      Status: REVIEWED

      Source sequence(s)
      AC234778
      Consensus CDS
      CCDS14672.1
      UniProtKB/Swiss-Prot
      O95751, Q6IAR6
      Related
      ENSP00000359557.2, ENST00000370526.5
      Conserved Domains (1) summary
      pfam16297
      Location:28131
      DUF4939; Domain of unknown function (DUF4939)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      141173235..141177129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      139490611..139494505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)