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    CA14 carbonic anhydrase 14 [ Homo sapiens (human) ]

    Gene ID: 23632, updated on 17-Jun-2019

    Summary

    Official Symbol
    CA14provided by HGNC
    Official Full Name
    carbonic anhydrase 14provided by HGNC
    Primary source
    HGNC:HGNC:1372
    See related
    Ensembl:ENSG00000118298 MIM:604832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAXiV
    Summary
    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 3.3), skin (RPKM 1.4) and 12 other tissues See more
    Orthologs

    Genomic context

    See CA14 in Genome Data Viewer
    Location:
    1q21.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (150257258..150265862)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (150229554..150237478)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member E Neighboring gene RNA, U2 small nuclear 17, pseudogene Neighboring gene small nucleolar RNA, C/D box 13C Neighboring gene aph-1 homolog A, gamma-secretase subunit Neighboring gene chromosome 1 open reading frame 54 Neighboring gene circadian associated repressor of transcription

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Nitrogen metabolism, organism-specific biosystem (from KEGG)
      Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Nitrogen metabolism, conserved biosystem (from KEGG)
      Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Reversible hydration of carbon dioxide, organism-specific biosystem (from REACTOME)
      Reversible hydration of carbon dioxide, organism-specific biosystemCarbonic anhydrases reversibly catalyze the hydration of carbon dioxide and directly produce bicarbonate and protons, bypassing the formation of carbonic acid (reviewed in Lindskog 1997, Breton 2001,...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bicarbonate transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    carbonic anhydrase 14
    Names
    CA-XIV
    carbonate dehydratase XIV
    carbonic anhydrase XIV
    carbonic dehydratase
    NP_036245.1
    XP_005245116.1
    XP_005245117.1
    XP_006711322.1
    XP_006711324.1
    XP_011507681.1
    XP_016856382.1
    XP_016856383.1
    XP_016856384.1
    XP_016856385.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012113.3NP_036245.1  carbonic anhydrase 14 precursor

      See identical proteins and their annotated locations for NP_036245.1

      Status: REVIEWED

      Source sequence(s)
      AB025904, AK315469, BP361793
      Consensus CDS
      CCDS947.1
      UniProtKB/Swiss-Prot
      Q9ULX7
      UniProtKB/TrEMBL
      A8K3J4
      Related
      ENSP00000358107.3, ENST00000369111.9
      Conserved Domains (1) summary
      cd03126
      Location:29278
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      150257258..150265862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509379.3XP_011507681.1  carbonic anhydrase 14 isoform X2

      Conserved Domains (2) summary
      cl00012
      Location:50264
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
      cl23791
      Location:277308
      UPF0154; uncharacterized protein family (UPF0154)
    2. XM_005245060.3XP_005245117.1  carbonic anhydrase 14 isoform X3

      Conserved Domains (1) summary
      cd03126
      Location:29278
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
    3. XM_005245059.3XP_005245116.1  carbonic anhydrase 14 isoform X1

      See identical proteins and their annotated locations for XP_005245116.1

      Conserved Domains (1) summary
      cd03126
      Location:29278
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
    4. XM_006711259.3XP_006711322.1  carbonic anhydrase 14 isoform X4

      Conserved Domains (1) summary
      cd03126
      Location:29278
      alpha_CA_XII_XIV; Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, ...
    5. XM_017000894.2XP_016856383.1  carbonic anhydrase 14 isoform X7

    6. XM_017000895.2XP_016856384.1  carbonic anhydrase 14 isoform X8

    7. XM_006711261.3XP_006711324.1  carbonic anhydrase 14 isoform X5

      Conserved Domains (2) summary
      cl00012
      Location:8222
      alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
      cl23791
      Location:235266
      UPF0154; uncharacterized protein family (UPF0154)
    8. XM_017000893.2XP_016856382.1  carbonic anhydrase 14 isoform X6

    9. XM_017000896.2XP_016856385.1  carbonic anhydrase 14 isoform X9

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