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    TSSK2 testis specific serine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 23617, updated on 15-Jun-2019

    Summary

    Official Symbol
    TSSK2provided by HGNC
    Official Full Name
    testis specific serine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11401
    See related
    Ensembl:ENSG00000206203 MIM:610710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSK2; DGS-G; SPOGA2; STK22B
    Summary
    TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
    Orthologs

    Genomic context

    See TSSK2 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (19130808..19132623)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19118321..19120136)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene ribosomal protein L28 pseudogene Neighboring gene testis specific serine kinase 1A, pseudogene Neighboring gene uncharacterized LOC112268297 Neighboring gene ess-2 splicing factor homolog Neighboring gene goosecoid homeobox 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein testis-specific serine kinase 2 (TSSK2) PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ38613

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    centriole IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus HDA PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    testis-specific serine/threonine-protein kinase 2
    Names
    TSK-2
    TSSK-2
    diGeorge syndrome protein G
    serine/threonine kinase 22B (spermiogenesis associated)
    serine/threonine-protein kinase 22B
    spermiogenesis associated 2
    testicular secretory protein Li 61
    testis specific serine threonine kinase 2
    testis-specific kinase 2
    NP_443732.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053006.5NP_443732.3  testis-specific serine/threonine-protein kinase 2

      See identical proteins and their annotated locations for NP_443732.3

      Status: VALIDATED

      Source sequence(s)
      BC037781, L77564
      Consensus CDS
      CCDS13755.1
      UniProtKB/Swiss-Prot
      Q96PF2
      UniProtKB/TrEMBL
      A0ZT99
      Related
      ENSP00000382544.2, ENST00000399635.4
      Conserved Domains (2) summary
      smart00220
      Location:12272
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14165
      Location:10272
      STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      19131308..19132622
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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