Format

Send to:

Choose Destination
    • Showing Current items.

    PDSS1 decaprenyl diphosphate synthase subunit 1 [ Homo sapiens (human) ]

    Gene ID: 23590, updated on 17-Jun-2019

    Summary

    Official Symbol
    PDSS1provided by HGNC
    Official Full Name
    decaprenyl diphosphate synthase subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:17759
    See related
    Ensembl:ENSG00000148459 MIM:607429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPS; SPS; TPT; COQ1; TPRT; COQ1A; TPT 1; hDPS1; COQ10D2
    Summary
    The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 4.4), small intestine (RPKM 3.8) and 24 other tissues See more
    Orthologs

    Genomic context

    See PDSS1 in Genome Data Viewer
    Location:
    10p12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (26697424..26747246)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (26986353..27035727)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 238 member B Neighboring gene selenoprotein O like, pseudogene Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 3 Neighboring gene abl interactor 1 Neighboring gene RNA, U6 small nuclear 946, pseudogene Neighboring gene family with sequence similarity 238 member C Neighboring gene ankyrin repeat domain 26

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of prenyl (decaprenyl) diphosphate synthase, subunit 1 (PDSS1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Terpenoid backbone biosynthesis, organism-specific biosystem (from KEGG)
      Terpenoid backbone biosynthesis, organism-specific biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
    • Terpenoid backbone biosynthesis, conserved biosystem (from KEGG)
      Terpenoid backbone biosynthesis, conserved biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
    • Ubiquinol biosynthesis, organism-specific biosystem (from REACTOME)
      Ubiquinol biosynthesis, organism-specific biosystemThe length of the polyisoprenoid chain of ubiquinone aka coenzyme Q (Q), varies depending on the species involved: it is 6 in budding yeast, Saccharomyces cerevisiae, (Q6) and 10 in humans (Q10). Mo...
    • all-trans-decaprenyl diphosphate biosynthesis, conserved biosystem (from BIOCYC)
      all-trans-decaprenyl diphosphate biosynthesis, conserved biosystemIn this pathway multiple units of |FRAME: DELTA3-ISOPENTENYL-PP| (IPP) undergo a series of polymerizations to form a polyisoprenoid chain. The sequential addition of isoprenyl units to |FRAME: FARNE...
    • ubiquinol-10 biosynthesis, organism-specific biosystem (from BIOCYC)
      ubiquinol-10 biosynthesis, organism-specific biosystemGeneral Background Ubiquinone, also known as coenzyme Q, is a crucial component of the electron transport chain in eukaryotes and prokaryotes . Ubiquinone is a lipid consisting of a hydrophobic isop...
    • ubiquinol-10 biosynthesis (eukaryotic), conserved biosystem (from BIOCYC)
      ubiquinol-10 biosynthesis (eukaryotic), conserved biosystemGeneral Background Ubiquinone (also known as coenzyme Q) is an isoprenoid quinone that functions as an electron carrier in membranes. In eukaryotes ubiquinone is found mostly within the inner mitoch...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC70953

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to trans-hexaprenyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-octaprenyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    isoprenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquinone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquinone biosynthetic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    transferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    decaprenyl-diphosphate synthase subunit 1
    Names
    all-trans-decaprenyl-diphosphate synthase subunit 1
    coenzyme Q1 homolog
    decaprenyl pyrophosphate synthase subunit 1
    polyprenyl pyrophosphate synthetase
    prenyl (decaprenyl) diphosphate synthase, subunit 1
    subunit 1 of decaprenyl diphosphate synthase
    trans-prenyltransferase (TPT)
    trans-prenyltransferase 1
    NP_001308907.1
    NP_001308908.1
    NP_055132.2
    XP_011517739.1
    XP_016871500.1
    XP_024303690.1
    XP_024303691.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008972.2 RefSeqGene

      Range
      4759..54133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321978.1NP_001308907.1  decaprenyl-diphosphate synthase subunit 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK024802, AL390961, BC063635
      UniProtKB/Swiss-Prot
      Q5T2R2
      Conserved Domains (1) summary
      cd00685
      Location:121277
      Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
    2. NM_001321979.1NP_001308908.1  decaprenyl-diphosphate synthase subunit 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL390961
      Conserved Domains (1) summary
      cl00210
      Location:1243
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    3. NM_014317.5NP_055132.2  decaprenyl-diphosphate synthase subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_055132.2

      Status: REVIEWED

      Source sequence(s)
      AK024802, BC049211
      Consensus CDS
      CCDS31168.1
      UniProtKB/Swiss-Prot
      Q5T2R2
      Related
      ENSP00000365388.5, ENST00000376215.10
      Conserved Domains (2) summary
      PLN02890
      Location:6415
      PLN02890; geranyl diphosphate synthase
      cl00210
      Location:102413
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      26697424..26747246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447922.1XP_024303690.1  decaprenyl-diphosphate synthase subunit 1 isoform X1

      Conserved Domains (1) summary
      cd00685
      Location:121343
      Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
    2. XM_017016011.2XP_016871500.1  decaprenyl-diphosphate synthase subunit 1 isoform X2

    3. XM_024447923.1XP_024303691.1  decaprenyl-diphosphate synthase subunit 1 isoform X4

      Conserved Domains (1) summary
      cl00210
      Location:1243
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    4. XM_011519437.3XP_011517739.1  decaprenyl-diphosphate synthase subunit 1 isoform X3

      Conserved Domains (1) summary
      cl00210
      Location:2290
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RNA

    1. XR_428636.4 RNA Sequence

    Support Center