Format

Send to:

Choose Destination
    • Showing Current items.

    SLC35A3 solute carrier family 35 member A3 [ Homo sapiens (human) ]

    Gene ID: 23443, updated on 17-Jun-2019

    Summary

    Official Symbol
    SLC35A3provided by HGNC
    Official Full Name
    solute carrier family 35 member A3provided by HGNC
    Primary source
    HGNC:HGNC:11023
    See related
    Ensembl:ENSG00000117620 MIM:605632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMRS
    Summary
    This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in colon (RPKM 21.3), duodenum (RPKM 16.3) and 24 other tissues See more
    Orthologs

    Genomic context

    See SLC35A3 in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (99968401..100035634)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100435345..100492535)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 9 Neighboring gene amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase Neighboring gene RNA, U6 small nuclear 750, pseudogene Neighboring gene RNA, U6 small nuclear 1318, pseudogene Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene SAS-6 centriolar assembly protein Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene leucine rich repeat containing 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp781P1297

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    UDP-N-acetylglucosamine transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    UDP-N-acetylglucosamine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    UDP-N-acetylglucosamine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    integral component of Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    UDP-N-acetylglucosamine transporter
    Names
    golgi UDP-GlcNAc transporter
    solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
    solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033857.1 RefSeqGene

      Range
      5001..62191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001271684.2NP_001258613.1  UDP-N-acetylglucosamine transporter isoform 2

      See identical proteins and their annotated locations for NP_001258613.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC093019, AC118553, AV698459, BC005136, CR749816
      Consensus CDS
      CCDS60205.1
      UniProtKB/Swiss-Prot
      Q9Y2D2
      Related
      ENSP00000491145.1, ENST00000638336.1
      Conserved Domains (1) summary
      pfam04142
      Location:4220
      Nuc_sug_transp; Nucleotide-sugar transporter
    2. NM_001271685.2NP_001258614.1  UDP-N-acetylglucosamine transporter isoform 3

      See identical proteins and their annotated locations for NP_001258614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, which introduces an upstream start codon, compared to variant 1. It encodes isoform 3, which has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AC093019, AC118553, CR749816
      Consensus CDS
      CCDS60204.1
      UniProtKB/Swiss-Prot
      Q9Y2D2
      Related
      ENSP00000359172.1, ENST00000370153.6
      Conserved Domains (2) summary
      TIGR00803
      Location:128354
      nst; UDP-galactose transporter
      pfam04142
      Location:46355
      Nuc_sug_transp; Nucleotide-sugar transporter
    3. NM_012243.3NP_036375.1  UDP-N-acetylglucosamine transporter isoform 1

      See identical proteins and their annotated locations for NP_036375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AB021981, AC093019, AC118553, CR749816
      Consensus CDS
      CCDS762.1
      UniProtKB/Swiss-Prot
      Q9Y2D2
      Related
      ENSP00000433849.1, ENST00000533028.8
      Conserved Domains (2) summary
      TIGR00803
      Location:86312
      nst; UDP-galactose transporter
      pfam04142
      Location:4313
      Nuc_sug_transp; Nucleotide-sugar transporter

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      99968401..100035634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005270691.5XP_005270748.1  UDP-N-acetylglucosamine transporter isoform X2

      See identical proteins and their annotated locations for XP_005270748.1

      UniProtKB/Swiss-Prot
      Q9Y2D2
      Related
      ENSP00000414947.2, ENST00000427993.7
      Conserved Domains (2) summary
      TIGR00803
      Location:86312
      nst; UDP-galactose transporter
      pfam04142
      Location:4313
      Nuc_sug_transp; Nucleotide-sugar transporter
    2. XM_017000869.2XP_016856358.1  UDP-N-acetylglucosamine transporter isoform X4

      UniProtKB/TrEMBL
      A0A1W2PRT7
      Related
      ENSP00000492771.1, ENST00000640732.1
    3. XM_017000871.2XP_016856360.1  UDP-N-acetylglucosamine transporter isoform X7

      UniProtKB/TrEMBL
      A0A1W2PQL8
      Related
      ENSP00000492169.1, ENST00000639221.1
    4. XM_017000870.2XP_016856359.1  UDP-N-acetylglucosamine transporter isoform X5

      UniProtKB/TrEMBL
      A0A1W2PSD1
      Related
      ENSP00000492801.1, ENST00000640715.1
    5. XM_011541138.3XP_011539440.1  UDP-N-acetylglucosamine transporter isoform X6

      Conserved Domains (1) summary
      cl23754
      Location:128258
      EamA; EamA-like transporter family
    6. XM_011541135.3XP_011539437.1  UDP-N-acetylglucosamine transporter isoform X1

      Conserved Domains (2) summary
      TIGR00803
      Location:128313
      nst; UDP-galactose transporter
      pfam04142
      Location:46314
      Nuc_sug_transp; Nucleotide-sugar transporter
    7. XM_011541137.3XP_011539439.1  UDP-N-acetylglucosamine transporter isoform X3

      Conserved Domains (1) summary
      TIGR00803
      Location:128293
      nst; UDP-galactose transporter
    8. XM_011541136.2XP_011539438.1  UDP-N-acetylglucosamine transporter isoform X2

      See identical proteins and their annotated locations for XP_011539438.1

      UniProtKB/Swiss-Prot
      Q9Y2D2
      Conserved Domains (2) summary
      TIGR00803
      Location:86312
      nst; UDP-galactose transporter
      pfam04142
      Location:4313
      Nuc_sug_transp; Nucleotide-sugar transporter
    Support Center