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    GPR161 G protein-coupled receptor 161 [ Homo sapiens (human) ]

    Gene ID: 23432, updated on 17-Jun-2019

    Summary

    Official Symbol
    GPR161provided by HGNC
    Official Full Name
    G protein-coupled receptor 161provided by HGNC
    Primary source
    HGNC:HGNC:23694
    See related
    Ensembl:ENSG00000143147 MIM:612250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RE2
    Summary
    The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, this gene is a potential drug target for triple-negative breast cancer. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues See more
    Orthologs

    Genomic context

    See GPR161 in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (168079542..168137667, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168048780..168106905, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene microRNA 1255b-2 Neighboring gene glycine cleavage system protein H pseudogene 5 Neighboring gene TOR signaling pathway regulator Neighboring gene ribosomal protein L34 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
      Hedgehog 'off' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
    • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
      Hedgehog 'on' state, organism-specific biosystemHedgehog is a secreted morphogen that has evolutionarily conserved roles in body organization by regulating the activity of the Ci/Gli transcription factor family. In Drosophila in the absence of Hh ...
    • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
      Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Hedgehog signaling pathway, conserved biosystem (from KEGG)
      Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
      Signaling by Hedgehog, organism-specific biosystemHedgehog (Hh) is a secreted morphogen that regulates developmental processes in vertebrates including limb bud formation, neural tube patterning, cell growth and differentiation (reviewed in Hui and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ33952

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    ciliary membrane TAS
    Traceable Author Statement
    more info
     
    cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    G-protein coupled receptor 161
    Names
    G-protein coupled receptor RE2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053052.1 RefSeqGene

      Range
      5961..63126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267609.1NP_001254538.1  G-protein coupled receptor 161 isoform 1

      See identical proteins and their annotated locations for NP_001254538.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA662800, AK299634, AL033532
      Consensus CDS
      CCDS58043.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000441039.1, ENST00000537209.5
      Conserved Domains (2) summary
      pfam00001
      Location:64344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:55184
      7tm_4; Olfactory receptor
    2. NM_001267610.1NP_001254539.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_001254539.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2, 3, 8, 9, and 10 all encode the same isoform (2).
      Source sequence(s)
      AA662800, AK122656, AL033532
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000356809.1, ENST00000367835.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_001267611.1NP_001254540.1  G-protein coupled receptor 161 isoform 3

      See identical proteins and their annotated locations for NP_001254540.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' coding region, and initiates translation at an upstream start codon, compared to variant 1. The resulting isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA662800, AK310019, AL033532
      Consensus CDS
      CCDS72978.1
      UniProtKB/TrEMBL
      A0A0A0MQW8
      Related
      ENSP00000271357.6, ENST00000271357.9
      Conserved Domains (2) summary
      pfam00001
      Location:61341
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52181
      7tm_4; Olfactory receptor
    4. NM_001267612.1NP_001254541.1  G-protein coupled receptor 161 isoform 4

      See identical proteins and their annotated locations for NP_001254541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus compared to isoform 1. Variants 5 and 11 both encode the same isoform (4).
      Source sequence(s)
      AA662800, AK056040, AL033532
      Consensus CDS
      CCDS58042.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000356810.1, ENST00000367836.5
      Conserved Domains (2) summary
      cd14964
      Location:1430
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    5. NM_001267613.1NP_001254542.1  G-protein coupled receptor 161 isoform 5

      See identical proteins and their annotated locations for NP_001254542.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks a portion of the 5' CDS compared to variant 1. These differences cause translation initiation an alternate start codon compared to variant 1. The resulting isoform (5) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA662800, AK298797, AL033532
      Consensus CDS
      CCDS58044.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000437576.1, ENST00000539777.5
      Conserved Domains (1) summary
      pfam00001
      Location:48246
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    6. NM_001267614.1NP_001254543.1  G-protein coupled receptor 161 isoform 6

      See identical proteins and their annotated locations for NP_001254543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks a portion of the 5' coding region, initiates translation at an upstream start codon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AA662800, AK298850, AL033532
      Consensus CDS
      CCDS58045.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000444348.1, ENST00000546300.5
      Conserved Domains (1) summary
      pfam00001
      Location:12210
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. NM_001349632.1NP_001336561.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 2, 3, 9, and 10, encodes isoform 2.
      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    8. NM_001349633.1NP_001336562.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 2, 3, 8, and 10, encodes isoform 2.
      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    9. NM_001349634.1NP_001336563.1  G-protein coupled receptor 161 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 2, 3, 8, and 9, encodes isoform 2.
      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS1268.1
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. NM_001349635.1NP_001336564.1  G-protein coupled receptor 161 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 5, encodes isoform 4.
      Source sequence(s)
      AL033532
      Consensus CDS
      CCDS58042.1
      Conserved Domains (2) summary
      cd14964
      Location:1430
      7tm_GPCRs; TM helix 4 [structural motif]
      cl28897
      Location:1203
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    11. NM_153832.2NP_722561.1  G-protein coupled receptor 161 isoform 2

      See identical proteins and their annotated locations for NP_722561.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) is shorter compared to isoform 1. Variants 2, 3, 8, 9, and 10 all encode the same isoform (2).
      Source sequence(s)
      AA662800, AL033532, BC028163
      Consensus CDS
      CCDS1268.1
      UniProtKB/Swiss-Prot
      Q8N6U8
      Related
      ENSP00000356812.1, ENST00000367838.5
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      168079542..168137667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509372.1XP_011507674.1  G-protein coupled receptor 161 isoform X2

      See identical proteins and their annotated locations for XP_011507674.1

      Conserved Domains (2) summary
      pfam00001
      Location:67347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:58187
      7tm_4; Olfactory receptor
    2. XM_011509371.2XP_011507673.1  G-protein coupled receptor 161 isoform X2

      See identical proteins and their annotated locations for XP_011507673.1

      Conserved Domains (2) summary
      pfam00001
      Location:67347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:58187
      7tm_4; Olfactory receptor
    3. XM_005245056.2XP_005245113.1  G-protein coupled receptor 161 isoform X4

      See identical proteins and their annotated locations for XP_005245113.1

      UniProtKB/Swiss-Prot
      Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. XM_011509378.1XP_011507680.1  G-protein coupled receptor 161 isoform X4

      See identical proteins and their annotated locations for XP_011507680.1

      UniProtKB/Swiss-Prot
      Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. XM_011509376.2XP_011507678.1  G-protein coupled receptor 161 isoform X4

      See identical proteins and their annotated locations for XP_011507678.1

      UniProtKB/Swiss-Prot
      Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. XM_011509373.2XP_011507675.1  G-protein coupled receptor 161 isoform X2

      See identical proteins and their annotated locations for XP_011507675.1

      Conserved Domains (2) summary
      pfam00001
      Location:67347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:58187
      7tm_4; Olfactory receptor
    7. XM_005245055.2XP_005245112.1  G-protein coupled receptor 161 isoform X3

      See identical proteins and their annotated locations for XP_005245112.1

      UniProtKB/Swiss-Prot
      Q8N6U8
      Conserved Domains (2) summary
      pfam00001
      Location:64344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:55184
      7tm_4; Olfactory receptor
    8. XM_006711251.1XP_006711314.1  G-protein coupled receptor 161 isoform X2

      See identical proteins and their annotated locations for XP_006711314.1

      Conserved Domains (2) summary
      pfam00001
      Location:67347
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:58187
      7tm_4; Olfactory receptor
    9. XM_005245057.4XP_005245114.1  G-protein coupled receptor 161 isoform X4

      See identical proteins and their annotated locations for XP_005245114.1

      UniProtKB/Swiss-Prot
      Q8N6U8
      Conserved Domains (1) summary
      cd15214
      Location:29335
      7tmA_GPR161; orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors
    10. XM_006711253.2XP_006711316.2  G-protein coupled receptor 161 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_007369.2: Suppressed sequence

      Description
      NM_007369.2: This RefSeq was suppressed because it mistakenly represents a partial CDS. The full-length CDS is represented in a different record (NM_153832).
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