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    SIRT1 sirtuin 1 [ Homo sapiens (human) ]

    Gene ID: 23411, updated on 20-Nov-2022

    Summary

    Official Symbol
    SIRT1provided by HGNC
    Official Full Name
    sirtuin 1provided by HGNC
    Primary source
    HGNC:HGNC:14929
    See related
    Ensembl:ENSG00000096717 MIM:604479; AllianceGenome:HGNC:14929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2; SIR2L1; SIR2alpha
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SIRT1 in Genome Data Viewer
    Location:
    10q21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (67884656..67918390)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (68753401..68787131)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69644414..69678147)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 523, pseudogene Neighboring gene SIRT1 promoter region Neighboring gene Sharpr-MPRA regulatory region 7890 Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene RPS3A pseudogene 38 Neighboring gene RNA, 7SL, cytoplasmic 220, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of SIRT1 by shRNA enhances HIV-1 transactivation in HIV latency condition, suggesting the direct involvement of SIRT1 to HIV latency PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of SIRT1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat-induced inhibition of SIRT1 activity in TZM-bl cells is reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
    tat HIV-1 Tat modulates SIRT1 expression in neuron cells PubMed
    tat HIV-1 Tat upregulates miR-182 in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity by MiR-182 PubMed
    tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
    tat HIV-1 Tat upregulates miR-34a in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity and induction of NFkappaB p65 acetylation by MiR-34a PubMed
    tat HIV-1 Tat-induced expression of miR-217 downregulates SIRT1 and promotes HIV-1 LTR transactivation in MAGI cells PubMed
    tat HIV-1 Tat is identified to have a physical interaction with sirtuin 1 (SIRT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed
    tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
    tat Overexpression of SIRT1 attenuates Tat-induced HIV-1 transcription in MAGI cells PubMed
    tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
    tat Deacetylation of HIV-1 Tat by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase, regulates Tat transactivation of the HIV-1 promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables HLH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables NAD+ ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT enables NAD+-protein ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables NAD-dependent histone H3K9 deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NAD-dependent histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent histone decrotonylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables NAD-dependent protein deacetylase activity TAS
    Traceable Author Statement
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone deacetylase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables keratin filament binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables promoter-specific chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein lysine deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein lysine deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-propionyllysine depropionylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent heterochromatin formation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA synthesis involved in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in UV-damage excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in behavioral response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to ionizing radiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H3 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cellular response to testosterone stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cellular senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of histone H3-K14 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of histone H3-K9 trimethylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of histone H4-K16 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of peptidyl-lysine acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of protein acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ovulation from ovarian follicle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-lysine acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of adaptive immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cAMP-dependent protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cholesterol efflux ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of histone H3-K9 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of histone methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of macrophage apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of macrophage cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deacetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein depropionylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pyrimidine dimer repair by nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rDNA heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rDNA heterochromatin formation TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of bile acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of brown fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    involved_in regulation of centrosome duplication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of endodeoxyribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of lipid storage ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of peroxisome proliferator activated receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to insulin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to leptin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in single strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-induced premature senescence IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in triglyceride mobilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in white fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of eNoSc complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    NAD-dependent protein deacetylase sirtuin-1
    Names
    NAD-dependent protein deacylase sirtuin-1
    SIR2-like protein 1
    regulatory protein SIR2 homolog 1
    sirtuin type 1
    NP_001135970.1
    NP_001300978.1
    NP_036370.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050664.2 RefSeqGene

      Range
      5002..38736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142498.2NP_001135970.1  NAD-dependent protein deacetylase sirtuin-1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL133551
      Consensus CDS
      CCDS44412.1
      UniProtKB/Swiss-Prot
      Q96EB6
      UniProtKB/TrEMBL
      A8K128, E9PC49
      Related
      ENSP00000409208.1, ENST00000432464.5
      Conserved Domains (1) summary
      cl00195
      Location:1194
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    2. NM_001314049.1NP_001300978.1  NAD-dependent protein deacetylase sirtuin-1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF235040, AK074805, BC012499, DB162635
      Consensus CDS
      CCDS81469.1
      UniProtKB/Swiss-Prot
      Q96EB6
      UniProtKB/TrEMBL
      B0QZ35
      Related
      ENSP00000384508.1, ENST00000406900.5
      Conserved Domains (1) summary
      cl00195
      Location:12186
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
    3. NM_012238.5NP_036370.2  NAD-dependent protein deacetylase sirtuin-1 isoform a

      See identical proteins and their annotated locations for NP_036370.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL133551
      Consensus CDS
      CCDS7273.1
      UniProtKB/Swiss-Prot
      Q96EB6, Q9Y6F0
      UniProtKB/TrEMBL
      A0A024QZQ1
      Related
      ENSP00000212015.6, ENST00000212015.11
      Conserved Domains (1) summary
      cd01408
      Location:254489
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      67884656..67918390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      68753401..68787131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)