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    Tnrc6a trinucleotide repeat containing 6a [ Mus musculus (house mouse) ]

    Gene ID: 233833, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tnrc6aprovided by MGI
    Official Full Name
    trinucleotide repeat containing 6aprovided by MGI
    Primary source
    MGI:MGI:2385292
    See related
    Ensembl:ENSMUSG00000052707 AllianceGenome:MGI:2385292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GW182; Tnrc6; CAGH26; 2010321I05Rik; 3110054G10Rik; D130023A07Rik
    Summary
    This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnrc6a in Genome Data Viewer
    Location:
    7 F2- F3; 7 67.42 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122630324..122794519)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123031101..123195296)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498 Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene STARR-seq mESC enhancer starr_20085 Neighboring gene STARR-positive B cell enhancer ABC_E11366 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130281644-130281845 Neighboring gene STARR-seq mESC enhancer starr_20086 Neighboring gene STARR-seq mESC enhancer starr_20088 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 11 Neighboring gene STARR-seq mESC enhancer starr_20089 Neighboring gene STARR-seq mESC enhancer starr_20090 Neighboring gene Rho GTPase activating protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E4974 Neighboring gene STARR-seq mESC enhancer starr_20097

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC11932

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in P-body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maintenance of protein location in cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in miRNA-mediated gene silencing by inhibition of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in miRNA-mediated post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulatory ncRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in P-body ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of RISC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of RISC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    trinucleotide repeat-containing gene 6A protein
    Names
    GW182 autoantigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144925.3NP_659174.3  trinucleotide repeat-containing gene 6A protein

      Status: VALIDATED

      Source sequence(s)
      AC138364, AK147327, BF020619, BY720212, CD802917
      Consensus CDS
      CCDS57583.1
      UniProtKB/Swiss-Prot
      F6ZMJ4, Q3UHK8
      Related
      ENSMUSP00000091595.6, ENSMUST00000094053.7
      Conserved Domains (4) summary
      cd12711
      Location:17151797
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10601185
      Ago_hook; Argonaute hook
      pfam12938
      Location:12661416
      M_domain; M domain of GW182
      pfam16608
      Location:14391702
      TNRC6-PABC_bdg; TNRC6-PABC binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      122630324..122794519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241757.1XP_011240059.1  trinucleotide repeat-containing gene 6A protein isoform X1

      Conserved Domains (4) summary
      cd12711
      Location:17731855
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12891474
      M_domain; M domain of GW182
      pfam16608
      Location:14971760
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    2. XM_017322202.1XP_017177691.1  trinucleotide repeat-containing gene 6A protein isoform X6

      Conserved Domains (4) summary
      cd12711
      Location:17731855
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12891474
      M_domain; M domain of GW182
      pfam16608
      Location:14971760
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    3. XM_011241760.2XP_011240062.1  trinucleotide repeat-containing gene 6A protein isoform X5

      Conserved Domains (4) summary
      cd12711
      Location:17501832
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12891378
      M_domain; M domain of GW182
      pfam16608
      Location:14741737
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    4. XM_011241762.2XP_011240064.1  trinucleotide repeat-containing gene 6A protein isoform X7

      Conserved Domains (4) summary
      cd12711
      Location:17241806
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12751425
      M_domain; M domain of GW182
      pfam16608
      Location:14481711
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    5. XM_017322203.2XP_017177692.1  trinucleotide repeat-containing gene 6A protein isoform X10

      Conserved Domains (4) summary
      cd12711
      Location:17011783
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12751329
      M_domain; M domain of GW182
      pfam16608
      Location:14251688
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    6. XM_011241758.2XP_011240060.1  trinucleotide repeat-containing gene 6A protein isoform X3

      Conserved Domains (4) summary
      cd12711
      Location:17621844
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691183
      Ago_hook; Argonaute hook
      pfam12938
      Location:12781463
      M_domain; M domain of GW182
      pfam16608
      Location:14861749
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    7. XM_011241763.2XP_011240065.1  trinucleotide repeat-containing gene 6A protein isoform X9

      Conserved Domains (4) summary
      cd12711
      Location:17131795
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10691183
      Ago_hook; Argonaute hook
      pfam12938
      Location:12641414
      M_domain; M domain of GW182
      pfam16608
      Location:14371700
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    8. XM_036153008.1XP_036008901.1  trinucleotide repeat-containing gene 6A protein isoform X12

      Conserved Domains (5) summary
      pfam10427
      Location:10691183
      Ago_hook; Argonaute hook
      pfam12938
      Location:12641318
      M_domain; M domain of GW182
      pfam16608
      Location:14161677
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:16851776
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:596854
      ser_rich_anae_1; serine-rich protein
    9. XM_011241764.2XP_011240066.1  trinucleotide repeat-containing gene 6A protein isoform X15

      Conserved Domains (2) summary
      pfam10427
      Location:10691194
      Ago_hook; Argonaute hook
      pfam12938
      Location:12891361
      M_domain; M domain of GW182
    10. XM_011241765.3XP_011240067.1  trinucleotide repeat-containing gene 6A protein isoform X16

      UniProtKB/TrEMBL
      Q05CE3
      Conserved Domains (1) summary
      pfam10427
      Location:10691161
      Ago_hook; Argonaute hook
    11. XM_006507705.3XP_006507768.1  trinucleotide repeat-containing gene 6A protein isoform X2

      Conserved Domains (4) summary
      cd12711
      Location:17641846
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10601185
      Ago_hook; Argonaute hook
      pfam12938
      Location:12801465
      M_domain; M domain of GW182
      pfam16608
      Location:14881751
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    12. XM_017322204.3XP_017177693.1  trinucleotide repeat-containing gene 6A protein isoform X11

      Conserved Domains (4) summary
      cd12711
      Location:16921774
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10601185
      Ago_hook; Argonaute hook
      pfam12938
      Location:12661320
      M_domain; M domain of GW182
      pfam16608
      Location:14161679
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    13. XM_017322201.3XP_017177690.1  trinucleotide repeat-containing gene 6A protein isoform X4

      Conserved Domains (4) summary
      cd12711
      Location:17531835
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:10601174
      Ago_hook; Argonaute hook
      pfam12938
      Location:12691454
      M_domain; M domain of GW182
      pfam16608
      Location:14771740
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    14. XM_017322205.3XP_017177694.1  trinucleotide repeat-containing gene 6A protein isoform X13

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (4) summary
      cd12711
      Location:15091591
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:805930
      Ago_hook; Argonaute hook
      pfam12938
      Location:10251210
      M_domain; M domain of GW182
      pfam16608
      Location:12331496
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    15. XM_036153009.1XP_036008902.1  trinucleotide repeat-containing gene 6A protein isoform X14

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (5) summary
      pfam10427
      Location:805930
      Ago_hook; Argonaute hook
      pfam12938
      Location:10111161
      M_domain; M domain of GW182
      pfam16608
      Location:11861447
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:14551546
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:332590
      ser_rich_anae_1; serine-rich protein
    16. XM_017322206.3XP_017177695.1  trinucleotide repeat-containing gene 6A protein isoform X13

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Related
      ENSMUSP00000146266.2, ENSMUST00000205760.2
      Conserved Domains (4) summary
      cd12711
      Location:15091591
      RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
      pfam10427
      Location:805930
      Ago_hook; Argonaute hook
      pfam12938
      Location:10251210
      M_domain; M domain of GW182
      pfam16608
      Location:12331496
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
    17. XM_036153010.1XP_036008903.1  trinucleotide repeat-containing gene 6A protein isoform X14

      UniProtKB/TrEMBL
      A0A0U1RQ65
      Conserved Domains (5) summary
      pfam10427
      Location:805930
      Ago_hook; Argonaute hook
      pfam12938
      Location:10111161
      M_domain; M domain of GW182
      pfam16608
      Location:11861447
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:14551546
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:332590
      ser_rich_anae_1; serine-rich protein
    18. XM_036153007.1XP_036008900.1  trinucleotide repeat-containing gene 6A protein isoform X8

      Conserved Domains (5) summary
      pfam10427
      Location:10161141
      Ago_hook; Argonaute hook
      pfam12938
      Location:12361421
      M_domain; M domain of GW182
      pfam16608
      Location:14461707
      TNRC6-PABC_bdg; TNRC6-PABC binding domain
      cd12711
      Location:17151806
      RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
      NF033849
      Location:543801
      ser_rich_anae_1; serine-rich protein