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    LARP1 La ribonucleoprotein domain family member 1 [ Homo sapiens (human) ]

    Gene ID: 23367, updated on 19-Jun-2019

    Summary

    Official Symbol
    LARP1provided by HGNC
    Official Full Name
    La ribonucleoprotein domain family member 1provided by HGNC
    Primary source
    HGNC:HGNC:29531
    See related
    Ensembl:ENSG00000155506 MIM:612059
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LARP
    Expression
    Ubiquitous expression in thyroid (RPKM 29.3), brain (RPKM 25.2) and 25 other tissues See more
    Orthologs

    Genomic context

    See LARP1 in Genome Data Viewer
    Location:
    5q33.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (154682979..154817605)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154062224..154197167)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene CIR1P1-LARP1 intergenic CAGE-defined high expression enhancer Neighboring gene microRNA 3141 Neighboring gene microRNA 1303 Neighboring gene RNA, 7SL, cytoplasmic 803, pseudogene Neighboring gene ribosomal protein L21 pseudogene 57 Neighboring gene uncharacterized LOC112267936 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene CCR4-NOT transcription complex subunit 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated La ribonucleoprotein domain family, member 1 (LARP1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Interaction of HIV-1 Gag with La ribonucleoprotein domain family, member 1 (LARP1) is identified in a series of six affinity purification/mass spectrometry screens PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0731, MGC19556

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA binding HDA PubMed 
    RNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding HDA PubMed 
    eukaryotic initiation factor 4E binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 5'-UTR binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosomal small subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translation activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translation initiation factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to rapamycin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    translational initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with TORC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    colocalizes_with polysomal ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367713.1NP_001354642.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    2. NM_001367714.1NP_001354643.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    3. NM_001367715.1NP_001354644.1  la-related protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    4. NM_001367716.1NP_001354645.1  la-related protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    5. NM_001367717.1NP_001354646.1  la-related protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008379, AC112169
    6. NM_001367718.1NP_001354647.1  la-related protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC112169
    7. NM_001367719.1NP_001354648.1  la-related protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC112169
    8. NM_015315.5NP_056130.2  la-related protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056130.2

      Status: VALIDATED

      Source sequence(s)
      AB018274, AC008379, BC001460, BC038220, BQ422667
      Consensus CDS
      CCDS4328.1
      UniProtKB/Swiss-Prot
      Q6PKG0
      Related
      ENSP00000336721.4, ENST00000336314.9
      Conserved Domains (4) summary
      smart00684
      Location:849887
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:327399
      LARP_1; La RNA-binding domain of La-related protein 1
      cl25751
      Location:123535
      DUF4045; Domain of unknown function (DUF4045)
      cl26464
      Location:11251
      Atrophin-1; Atrophin-1 family
    9. NM_033551.3NP_291029.2  la-related protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC112169

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      154682979..154817605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714775.2XP_006714838.1  la-related protein 1 isoform X7

      Conserved Domains (2) summary
      smart00684
      Location:785823
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:263335
      LARP_1; La RNA-binding domain of La-related protein 1
    2. XM_011537616.1XP_011535918.1  la-related protein 1 isoform X5

      Conserved Domains (2) summary
      smart00684
      Location:818856
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:296368
      LARP_1; La RNA-binding domain of La-related protein 1
    3. XM_011537614.1XP_011535916.1  la-related protein 1 isoform X2

      Conserved Domains (3) summary
      smart00684
      Location:900938
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:378450
      LARP_1; La RNA-binding domain of La-related protein 1
      COG5193
      Location:177529
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    4. XM_011537615.1XP_011535917.1  la-related protein 1 isoform X4

      Conserved Domains (3) summary
      smart00684
      Location:859897
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:337409
      LARP_1; La RNA-binding domain of La-related protein 1
      COG5193
      Location:211488
      LHP1; La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]
    5. XM_005268408.3XP_005268465.1  la-related protein 1 isoform X8

      See identical proteins and their annotated locations for XP_005268465.1

      Conserved Domains (2) summary
      smart00684
      Location:721759
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:199271
      LARP_1; La RNA-binding domain of La-related protein 1
    6. XM_011537617.1XP_011535919.1  la-related protein 1 isoform X6

      Conserved Domains (2) summary
      smart00684
      Location:791829
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd08037
      Location:269341
      LARP_1; La RNA-binding domain of La-related protein 1
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