Format

Send to:

Choose Destination
    • Showing Current items.

    FN1 fibronectin 1 [ Homo sapiens (human) ]

    Gene ID: 2335, updated on 19-Sep-2021

    Summary

    Official Symbol
    FN1provided by HGNC
    Official Full Name
    fibronectin 1provided by HGNC
    Primary source
    HGNC:HGNC:3778
    See related
    Ensembl:ENSG00000115414 MIM:135600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; SMDCF
    Summary
    This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in placenta (RPKM 1097.5), liver (RPKM 415.5) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FN1 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (215360862..215436167, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (216225588..216300791, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA host gene 31 Neighboring gene ATP binding cassette subfamily A member 12 Neighboring gene uncharacterized LOC112268430 Neighboring gene 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Neighboring gene uncharacterized LOC102724849 Neighboring gene FN1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
    GeneReviews: Not available
    Discovery and refinement of loci associated with lipid levels.
    GeneReviews: Not available
    Glomerulopathy with fibronectin deposits 2
    MedGen: C1866075 OMIM: 601894 GeneReviews: Not available
    not available
    Spondylometaphyseal dysplasia - Sutcliffe type not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces phosphorylation of fibronectin and enhances a physical association between fibronectin and Robo4 in human lymphatic endothelial cells PubMed
    env Fibronectin, which is present in submandibular saliva, binds to HIV-1 gp120/160 and enhances the interaction of C1q with gp120/160 PubMed
    env HIV-1 gp120 binds to fibronectin (FN) present on the surface of platelets; the specificity of this binding is confirmed by the inhibition obtained by pretreating platelets with anti-FN antibodies PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 and gp120 specifically recognize the C-terminal heparin-binding domain of fibronectin (Fn) and this binding inhibits the interaction of gp160/gp120 with soluble CD4 PubMed
    Envelope transmembrane glycoprotein gp41 env Fibronectin (FN) binds to HIV-1 glycoproteins, including gp41 and gp120; preincubation with antibodies against FN abolishes this binding PubMed
    Nef nef Exogenous HIV-1 Nef upregulates fibronectin (FN) expression in MT4 and H9 T-cell lines PubMed
    Tat tat HIV-1 Tat competes with fibronectin for binding to integrins PubMed
    tat Fibronectin modulates the effects of HIV-1 Tat on endothelial cells and murine Kaposi's sarcoma-like cells PubMed
    tat HIV-1 Tat upregulates fibronectin expression in salivary gland cell lines, thymic epithelial cells, and glioblastoma cells PubMed
    retropepsin gag-pol The cell-associated protein fibronectin (A-chain) is specifically cleaved in vitro by HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686H0342, DKFZp686I1370, DKFZp686F10164, DKFZp686O13149

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables collagen binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables extracellular matrix structural constituent HDA PubMed 
    enables extracellular matrix structural constituent ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables heparin binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables integrin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in biological process involved in interaction with symbiont IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood coagulation, fibrin clot formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in calcium-independent cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell-substrate junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in endodermal cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in neural crest cell migration involved in autonomic nervous system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide cross-linking IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet aggregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in blood microparticle HDA PubMed 
    colocalizes_with collagen-containing extracellular matrix HDA PubMed 
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of fibrinogen complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    fibronectin
    Names
    cold-insoluble globulin
    epididymis secretory sperm binding protein
    migration-stimulating factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012196.1 RefSeqGene

      Range
      5001..80629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306129.2NP_001293058.2  fibronectin isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77526.1
      Related
      ENSP00000323534.6, ENST00000323926.10
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23542393
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    2. NM_001306130.2NP_001293059.2  fibronectin isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77525.1
      Related
      ENSP00000399538.2, ENST00000432072.6
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21752214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    3. NM_001306131.2NP_001293060.2  fibronectin isoform 10 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77523.1
      Related
      ENSP00000415018.1, ENST00000443816.5
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21732212
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    4. NM_001306132.2NP_001293061.2  fibronectin isoform 11 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS77522.1
      Related
      ENSP00000394423.1, ENST00000421182.5
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21482187
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    5. NM_001365517.2NP_001352446.1  fibronectin isoform 12 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22952334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401619
      fn3; Fibronectin type III domain
    6. NM_001365518.2NP_001352447.1  fibronectin isoform 13 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Related
      ENSP00000352696.1, ENST00000359671.5
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491528
      fn3; Fibronectin type III domain
    7. NM_001365519.2NP_001352448.1  fibronectin isoform 14 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22702309
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401619
      fn3; Fibronectin type III domain
    8. NM_001365520.2NP_001352449.1  fibronectin isoform 15 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22692308
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491528
      fn3; Fibronectin type III domain
    9. NM_001365521.2NP_001352450.1  fibronectin isoform 16 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22642303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401619
      fn3; Fibronectin type III domain
    10. NM_001365522.2NP_001352451.1  fibronectin isoform 17 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22392278
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401619
      fn3; Fibronectin type III domain
    11. NM_001365523.2NP_001352452.1  fibronectin isoform 18 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21792218
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491528
      fn3; Fibronectin type III domain
    12. NM_001365524.2NP_001352453.1  fibronectin isoform 19 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Conserved Domains (5) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21742213
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491528
      fn3; Fibronectin type III domain
    13. NM_002026.4NP_002017.2  fibronectin isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS2399.1
      Related
      ENSP00000338200.4, ENST00000336916.8
    14. NM_054034.3NP_473375.2  fibronectin isoform 7 preproprotein

      See identical proteins and their annotated locations for NP_473375.2

      Status: REVIEWED

      Source sequence(s)
      AC012462
      Consensus CDS
      CCDS46512.1
      UniProtKB/Swiss-Prot
      P02751
      Related
      ENSP00000398907.1, ENST00000426059.1
      Conserved Domains (4) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:5289
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
    15. NM_212474.3NP_997639.2  fibronectin isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS2400.1
      Related
      ENSP00000350534.4, ENST00000357867.8
    16. NM_212476.3NP_997641.2  fibronectin isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS42813.1
      Related
      ENSP00000348285.4, ENST00000356005.8
    17. NM_212478.3NP_997643.2  fibronectin isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS46510.1
      Related
      ENSP00000410422.1, ENST00000446046.5
    18. NM_212482.4NP_997647.2  fibronectin isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC012462, AC073284
      Consensus CDS
      CCDS42814.1
      Related
      ENSP00000346839.4, ENST00000354785.11
      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23852424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      215360862..215436167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003692.1XP_016859181.1  fibronectin isoform X16

    2. XM_005246402.1XP_005246459.1  fibronectin isoform X6

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23292368
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    3. XM_024452769.1XP_024308537.1  fibronectin isoform X4

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23602399
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    4. XM_005246416.1XP_005246473.1  fibronectin isoform X24

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21482187
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:18141894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    5. XM_017003695.1XP_016859184.1  fibronectin isoform X20

    6. XM_005246404.1XP_005246461.1  fibronectin isoform X8

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22942333
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19041984
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:14491530
      fn3; Fibronectin type III domain
    7. XM_005246411.1XP_005246468.1  fibronectin isoform X21

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:21752214
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    8. XM_005246410.1XP_005246467.1  fibronectin isoform X18

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22392278
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    9. XM_024452770.1XP_024308538.1  fibronectin isoform X11

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22702309
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    10. XM_005246408.1XP_005246465.1  fibronectin isoform X13

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22642303
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    11. XM_005246403.1XP_005246460.1  fibronectin isoform X7

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22952334
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19051985
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    12. XM_005246407.1XP_005246464.1  fibronectin isoform X12

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:22652304
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    13. XM_005246401.1XP_005246458.1  fibronectin isoform X5

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23292368
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    14. XM_005246398.1XP_005246455.1  fibronectin isoform X2

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23602399
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    15. XM_005246399.1XP_005246456.1  fibronectin isoform X3

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23542393
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain
    16. XM_005246397.1XP_005246454.1  fibronectin isoform X1

      Conserved Domains (6) summary
      smart00059
      Location:353401
      FN2; Fibronectin type 2 domain
      smart00058
      Location:186230
      FN1; Fibronectin type 1 domain
      cd00061
      Location:23852424
      FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
      cd00063
      Location:19952075
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00039
      Location:231270
      fn1; Fibronectin type I domain
      pfam00041
      Location:15401621
      fn3; Fibronectin type III domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212475.1: Suppressed sequence

      Description
      NM_212475.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center