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    KIF13B kinesin family member 13B [ Homo sapiens (human) ]

    Gene ID: 23303, updated on 17-Jun-2019

    Summary

    Official Symbol
    KIF13Bprovided by HGNC
    Official Full Name
    kinesin family member 13Bprovided by HGNC
    Primary source
    HGNC:HGNC:14405
    See related
    Ensembl:ENSG00000197892 MIM:607350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAKIN
    Expression
    Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See KIF13B in Genome Data Viewer
    Location:
    8p12
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (29067278..29263385, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28924795..29120610, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene uncharacterized LOC105379346 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene dual specificity phosphatase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    NHGRI GWA Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    NHGRI GWA Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 signaling events, organism-specific biosystem
      Arf6 signaling events
    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0639

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-based movement TAS
    Traceable Author Statement
    more info
    PubMed 
    protein targeting TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    paranode region of axon IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF13B
    Names
    guanylate kinase associated kinesin
    kinesin 13B
    kinesin-like protein GAKIN

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015254.4NP_056069.2  kinesin-like protein KIF13B

      See identical proteins and their annotated locations for NP_056069.2

      Status: VALIDATED

      Source sequence(s)
      AB014539, AC108449, AI760125, DA068190, DA437040
      Consensus CDS
      CCDS55217.1
      UniProtKB/Swiss-Prot
      Q9NQT8
      Related
      ENSP00000427900.1, ENST00000524189.6
      Conserved Domains (10) summary
      smart00129
      Location:6360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:17041767
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:15391643
      Jun; Jun-like transcription factor
      pfam12423
      Location:756802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12211279
      DUF3694; Kinesin protein
      pfam16183
      Location:357469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10991143
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      29067278..29263385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544459.3XP_011542761.1  kinesin-like protein KIF13B isoform X4

      See identical proteins and their annotated locations for XP_011542761.1

      Conserved Domains (11) summary
      smart00129
      Location:9296
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:395508
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:383480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:3296
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:16611724
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:14961600
      Jun; Jun-like transcription factor
      pfam12423
      Location:692738
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571215
      DUF3694; Kinesin protein
      pfam16183
      Location:293405
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10351079
      DUF3585; Protein of unknown function (DUF3585)
    2. XM_011544461.1XP_011542763.1  kinesin-like protein KIF13B isoform X4

      See identical proteins and their annotated locations for XP_011542763.1

      Conserved Domains (11) summary
      smart00129
      Location:9296
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:395508
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:383480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:3296
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:16611724
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:14961600
      Jun; Jun-like transcription factor
      pfam12423
      Location:692738
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571215
      DUF3694; Kinesin protein
      pfam16183
      Location:293405
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10351079
      DUF3585; Protein of unknown function (DUF3585)
    3. XM_005273458.1XP_005273515.1  kinesin-like protein KIF13B isoform X3

      Conserved Domains (11) summary
      smart00129
      Location:6360
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:459572
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:447544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:16831746
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:15181622
      Jun; Jun-like transcription factor
      pfam12423
      Location:756802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12211279
      DUF3694; Kinesin protein
      pfam16183
      Location:357469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10991143
      DUF3585; Protein of unknown function (DUF3585)
    4. XM_011544458.1XP_011542760.1  kinesin-like protein KIF13B isoform X2

      Conserved Domains (10) summary
      smart00129
      Location:6360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:17041767
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:15391643
      Jun; Jun-like transcription factor
      pfam12423
      Location:756802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12211279
      DUF3694; Kinesin protein
      pfam16183
      Location:357469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10991143
      DUF3585; Protein of unknown function (DUF3585)
    5. XM_011544457.1XP_011542759.1  kinesin-like protein KIF13B isoform X1

      Conserved Domains (10) summary
      smart00129
      Location:6360
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:447544
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:4360
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:17251788
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:15601664
      Jun; Jun-like transcription factor
      pfam12423
      Location:756802
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12211279
      DUF3694; Kinesin protein
      pfam16183
      Location:357469
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:610710
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10991143
      DUF3585; Protein of unknown function (DUF3585)
    6. XM_011544460.3XP_011542762.1  kinesin-like protein KIF13B isoform X4

      See identical proteins and their annotated locations for XP_011542762.1

      Conserved Domains (11) summary
      smart00129
      Location:9296
      KISc; Kinesin motor, catalytic domain. ATPase
      COG1716
      Location:395508
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:383480
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:3296
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam01302
      Location:16611724
      CAP_GLY; CAP-Gly domain
      pfam03957
      Location:14961600
      Jun; Jun-like transcription factor
      pfam12423
      Location:692738
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11571215
      DUF3694; Kinesin protein
      pfam16183
      Location:293405
      Kinesin_assoc; Kinesin-associated
      cl23720
      Location:546646
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
      cl23748
      Location:10351079
      DUF3585; Protein of unknown function (DUF3585)
    7. XM_017013257.1XP_016868746.1  kinesin-like protein KIF13B isoform X5

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