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    TASOR transcription activation suppressor [ Homo sapiens (human) ]

    Gene ID: 23272, updated on 4-Jul-2021

    Summary

    Official Symbol
    TASORprovided by HGNC
    Official Full Name
    transcription activation suppressorprovided by HGNC
    Primary source
    HGNC:HGNC:30314
    See related
    Ensembl:ENSG00000163946 MIM:616493
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAP140; TASOR1; se89-1; C3orf63; FAM208A
    Expression
    Ubiquitous expression in testis (RPKM 15.9), lymph node (RPKM 11.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See TASOR in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (56620132..56683265, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (56654160..56717293, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene uncharacterized LOC105377099 Neighboring gene Sharpr-MPRA regulatory region 10072 Neighboring gene coiled-coil domain containing 66 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene ARHGEF3 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6639

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of C3orf63 by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed
    Knockdown of family with sequence similarity 208, member A (FAM208A; C3orf63) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1105, DKFZp686C2456

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    protein TASOR
    Names
    CTCL tumor antigen se89-1
    family with sequence similarity 208 member A
    protein FAM208A
    retinoblastoma-associated protein 140
    retinoblastoma-associated protein RAP140
    transgene activation suppressor protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112736.2NP_001106207.1  protein TASOR isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant contains an alternate 3' terminal exon, resulting in a frameshift compared to variant 4. The encoded isoform (a) has a novel C-terminus, and is shorter compared to isoform d.
      Source sequence(s)
      AC099781, AK094486, BC129987, BI559851, BX648955
      Consensus CDS
      CCDS46853.1
      UniProtKB/Swiss-Prot
      Q9UK61
      Related
      ENSP00000417509.2, ENST00000493960.6
      Conserved Domains (1) summary
      pfam12509
      Location:158319
      DUF3715; Protein of unknown function (DUF3715)
    2. NM_001363940.1NP_001350869.1  protein TASOR isoform c

      Status: VALIDATED

      Source sequence(s)
      AC099781
      Consensus CDS
      CCDS87094.1
      Related
      ENSP00000347845.5, ENST00000355628.9
      Conserved Domains (2) summary
      pfam12300
      Location:53110
      RhlB; ATP-dependent RNA helicase RhlB
      pfam12509
      Location:166319
      DUF3715; Protein of unknown function (DUF3715)
    3. NM_001365635.2NP_001352564.1  protein TASOR isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (d).
      Source sequence(s)
      AC099781
      Related
      ENSP00000508241.1, ENST00000683822.1
      Conserved Domains (2) summary
      pfam12300
      Location:53110
      RhlB; ATP-dependent RNA helicase RhlB
      pfam12509
      Location:166319
      DUF3715; Protein of unknown function (DUF3715)
    4. NM_001365636.2NP_001352565.1  protein TASOR isoform e

      Status: VALIDATED

      Source sequence(s)
      AC099781
      Conserved Domains (2) summary
      pfam12300
      Location:53110
      RhlB; ATP-dependent RNA helicase RhlB
      pfam12509
      Location:166319
      DUF3715; Protein of unknown function (DUF3715)
    5. NM_001365637.2NP_001352566.1  protein TASOR isoform f

      Status: VALIDATED

      Source sequence(s)
      AC099781
      Conserved Domains (2) summary
      pfam12300
      Location:53110
      RhlB; ATP-dependent RNA helicase RhlB
      pfam12509
      Location:166319
      DUF3715; Protein of unknown function (DUF3715)
    6. NM_001365638.2NP_001352567.1  protein TASOR isoform g

      Status: VALIDATED

      Source sequence(s)
      AC099781
      Conserved Domains (2) summary
      pfam12300
      Location:53110
      RhlB; ATP-dependent RNA helicase RhlB
      pfam12509
      Location:166319
      DUF3715; Protein of unknown function (DUF3715)
    7. NM_015224.3NP_056039.2  protein TASOR isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 5' coding exons and uses a downstream start codon compared to variant 4. The encoded isoform (b) has a shorter N-terminus compared to isoform d.
      Source sequence(s)
      AC099781, BC029354, BC129987
      Consensus CDS
      CCDS2877.1
      UniProtKB/Swiss-Prot
      Q9UK61
      Related
      ENSP00000399410.2, ENST00000431842.6

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      56620132..56683265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713078.2XP_006713141.1  protein TASOR isoform X6

      Related
      ENSP00000483340.1, ENST00000614531.1
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