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    SYNE2 spectrin repeat containing nuclear envelope protein 2 [ Homo sapiens (human) ]

    Gene ID: 23224, updated on 8-Aug-2021

    Summary

    Official Symbol
    SYNE2provided by HGNC
    Official Full Name
    spectrin repeat containing nuclear envelope protein 2provided by HGNC
    Primary source
    HGNC:HGNC:17084
    See related
    Ensembl:ENSG00000054654 MIM:608442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NUA; EDMD5; KASH2; Nesp2; TROPH; NUANCE; SYNE-2; Nesprin-2
    Summary
    The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
    Expression
    Ubiquitous expression in skin (RPKM 13.7), kidney (RPKM 12.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SYNE2 in Genome Data Viewer
    Location:
    14q23.2
    Exon count:
    123
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (63761904..64226449)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64319722..64693167)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 116 pseudogene Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene14 Neighboring gene ribosomal protein S28 pseudogene 1 Neighboring gene microRNA 548h-1 Neighboring gene estrogen receptor 2 Neighboring gene testis expressed 21, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Emery-Dreifuss muscular dystrophy 5, autosomal dominant
    MedGen: C2751805 OMIM: 612999 GeneReviews: Not available
    Compare labs
    Genome-wide association study of lung function decline in adults with and without asthma.
    GeneReviews: Not available
    Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ11014, FLJ43727, FLJ45710, FLJ46790, KIAA1011, DKFZp434H2235, DKFZp686H1931, DKFZp686E01115

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeleton-nuclear membrane anchor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nuclear migration along microfilament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in filopodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    located_in lamellipodium membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nesprin-2
    Names
    KASH domain-containing protein 2
    nesprin 2
    nuclear envelope spectrin repeat protein 2
    nucleus and actin connecting element protein
    polytrophin
    spectrin repeat containing, nuclear envelope 2
    synaptic nuclear envelope protein 2
    synaptic nuclei expressed gene 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011756.2 RefSeqGene

      Range
      96106..469535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_872

    mRNA and Protein(s)

    1. NM_015180.6NP_055995.4  nesprin-2 isoform 1

      See identical proteins and their annotated locations for NP_055995.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 5. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 5.
      Source sequence(s)
      AF435011, AF495911, AI685725, AL355094, DB271849
      Consensus CDS
      CCDS41963.1
      UniProtKB/Swiss-Prot
      Q8WXH0
      Related
      ENSP00000341781.4, ENST00000344113.8
      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68546885
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. NM_182910.2NP_878914.1  nesprin-2 isoform 2

      See identical proteins and their annotated locations for NP_878914.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (2) is shorter at the N-terminus compared to isoform 5.
      Source sequence(s)
      AI685725, AY184204
      Consensus CDS
      CCDS45125.1
      UniProtKB/Swiss-Prot
      Q8WXH0
      Related
      ENST00000441438.2
      Conserved Domains (2) summary
      cd00176
      Location:84307
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:398429
      KASH; Nuclear envelope localization domain
    3. NM_182913.4NP_878917.1  nesprin-2 isoform 4

      See identical proteins and their annotated locations for NP_878917.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 5. The resulting isoform (4) is shorter at the N-terminus compared to isoform 5.
      Source sequence(s)
      AI685725, AL355094, AY061758
      Consensus CDS
      CCDS45124.1
      UniProtKB/Swiss-Prot
      Q8WXH0
      Related
      ENSP00000391937.2, ENST00000458046.6
      Conserved Domains (2) summary
      cd00176
      Location:210433
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:525556
      KASH; Nuclear envelope localization domain
    4. NM_182914.3NP_878918.2  nesprin-2 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AL162832, AL355094, AL359235
      Consensus CDS
      CCDS9761.2
      UniProtKB/Swiss-Prot
      Q8WXH0
      UniProtKB/TrEMBL
      Q6MZP0
      Related
      ENSP00000450831.2, ENST00000555002.6
      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68766907
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      63761904..64226449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536576.2XP_011534878.1  nesprin-2 isoform X1

      See identical proteins and their annotated locations for XP_011534878.1

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69056936
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    2. XM_011536574.1XP_011534876.1  nesprin-2 isoform X1

      See identical proteins and their annotated locations for XP_011534876.1

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69056936
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    3. XM_011536578.1XP_011534880.1  nesprin-2 isoform X2

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69046935
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    4. XM_011536579.1XP_011534881.1  nesprin-2 isoform X4

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68916922
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    5. XM_005267454.1XP_005267511.1  nesprin-2 isoform X3

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68916922
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. XM_005267456.1XP_005267513.1  nesprin-2 isoform X5

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68906921
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    7. XM_005267457.1XP_005267514.1  nesprin-2 isoform X9

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68776908
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. XM_011536581.1XP_011534883.1  nesprin-2 isoform X8

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68826913
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    9. XM_005267458.1XP_005267515.1  nesprin-2 isoform X10

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68686899
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    10. XM_005267459.1XP_005267516.1  nesprin-2 isoform X12

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68536884
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    11. XM_011536582.1XP_011534884.1  nesprin-2 isoform X11

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682417
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:60986311
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68666897
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51395345
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    12. XM_011536580.2XP_011534882.1  nesprin-2 isoform X6

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:68906921
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    13. XM_011536584.2XP_011534886.1  nesprin-2 isoform X13

      Conserved Domains (5) summary
      COG1196
      Location:28733746
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      TIGR02168
      Location:18982639
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      cl02488
      Location:18402031
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    14. XM_011536577.2XP_011534879.1  nesprin-2 isoform X1

      See identical proteins and their annotated locations for XP_011534879.1

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69056936
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    15. XM_011536575.2XP_011534877.1  nesprin-2 isoform X1

      See identical proteins and their annotated locations for XP_011534877.1

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69056936
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    16. XM_017021101.1XP_016876590.1  nesprin-2 isoform X1

      Conserved Domains (7) summary
      COG0419
      Location:32983912
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      PRK03918
      Location:18682369
      PRK03918; chromosome segregation protein; Provisional
      cd00014
      Location:33135
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:61376350
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00307
      Location:182281
      CH; Calponin homology (CH) domain
      pfam10541
      Location:69056936
      KASH; Nuclear envelope localization domain
      cl02488
      Location:51785384
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    17. XM_017021102.1XP_016876591.1  nesprin-2 isoform X7

    18. XM_017021103.2XP_016876592.1  nesprin-2 isoform X14

      Related
      ENST00000555022.5
    19. XM_017021104.2XP_016876593.1  nesprin-2 isoform X15

    RNA

    1. XR_001750198.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182912.1: Suppressed sequence

      Description
      NM_182912.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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