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    FBXO28 F-box protein 28 [ Homo sapiens (human) ]

    Gene ID: 23219, updated on 15-Jun-2019

    Summary

    Official Symbol
    FBXO28provided by HGNC
    Official Full Name
    F-box protein 28provided by HGNC
    Primary source
    HGNC:HGNC:29046
    See related
    Ensembl:ENSG00000143756 MIM:609100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbx28; CENP-30
    Summary
    Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in skin (RPKM 11.4), esophagus (RPKM 8.4) and 25 other tissues See more
    Orthologs

    Genomic context

    See FBXO28 in Genome Data Viewer
    Location:
    1q42.11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (224114087..224162047)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (224301789..224349749)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373061 Neighboring gene uncharacterized LOC105373056 Neighboring gene RN7SK pseudogene 49 Neighboring gene zinc finger protein 706 pseudogene Neighboring gene delta 4-desaturase, sphingolipid 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ10766, KIAA0483

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    F-box only protein 28
    Names
    centromere protein 30

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136115.3NP_001129587.1  F-box only protein 28 isoform b

      See identical proteins and their annotated locations for NP_001129587.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL390122
      Consensus CDS
      CCDS44320.1
      UniProtKB/Swiss-Prot
      Q9NVF7
      Related
      ENSP00000416888.2, ENST00000424254.6
      Conserved Domains (1) summary
      pfam00646
      Location:6794
      F-box; F-box domain
    2. NM_015176.4NP_055991.1  F-box only protein 28 isoform a

      See identical proteins and their annotated locations for NP_055991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL390122
      Consensus CDS
      CCDS1539.1
      UniProtKB/Swiss-Prot
      Q9NVF7
      UniProtKB/TrEMBL
      A0A024R3Q6
      Related
      ENSP00000355827.5, ENST00000366862.10
      Conserved Domains (1) summary
      pfam00646
      Location:67108
      F-box; F-box domain

    RNA

    1. NR_049764.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB007952, AI354536, AK303381, AL390122, BP249147, DB136175

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      224114087..224162047
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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