Format

Send to:

Choose Destination
    • Showing Current items.

    SYT11 synaptotagmin 11 [ Homo sapiens (human) ]

    Gene ID: 23208, updated on 17-Jun-2019

    Summary

    Official Symbol
    SYT11provided by HGNC
    Official Full Name
    synaptotagmin 11provided by HGNC
    Primary source
    HGNC:HGNC:19239
    See related
    Ensembl:ENSG00000132718 MIM:608741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYT12; sytXI
    Summary
    This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]
    Annotation information
    Note: In 2002, the HUGO Gene Nomenclature Committee (HGNC) changed the official nomenclature of this locus to be standard with mouse and rat official nomenclature. Therefore, the gene previously known as "synaptotagmin XI" (SYT11, GeneID 23208) became "synaptotagmin XII" (SYT12) and "synaptotagmin XII" (SYT12, GeneID 91683) became "synaptotagmin XI" (SYT11). [13 Feb 2013]
    Expression
    Biased expression in brain (RPKM 160.9), adrenal (RPKM 11.8) and 1 other tissue See more
    Orthologs

    Genomic context

    See SYT11 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155859502..155885199)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155829260..155854990)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene gon-4 like Neighboring gene small Cajal body-specific RNA 26B Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene Ras like without CAAX 1 Neighboring gene small nucleolar RNA, H/ACA box 80E Neighboring gene KH domain containing 4, pre-mRNA splicing factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemRecruitment of plasma membrane-localized cargo into clathrin-coated endocytic vesicles is mediated by interaction with a variety of clathrin-interacting proteins collectively called CLASPs (clathrin-...
    • Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
      Clathrin-mediated endocytosis, organism-specific biosystemClathrin-mediated endocytosis (CME) is one of a number of process that control the uptake of material from the plasma membrane, and leads to the formation of clathrin-coated vesicles (Pearse et al, 1...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0080, MGC10881, MGC17226, DKFZp781D015

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    calcium ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion regulated lysosome exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion-regulated exocytosis of neurotransmitter IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of clathrin-coated pit assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of clathrin-dependent endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-6 secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of membrane invagination IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neurotransmitter secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tumor necrosis factor secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of protein localization to phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of dopamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of phagosome maturation IC
    Inferred by Curator
    more info
     
    vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell body IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    early phagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    excitatory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inhibitory synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    integral component of presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    presynapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    presynaptic active zone membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    recycling endosome IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic vesicle TAS
    Traceable Author Statement
    more info
    PubMed 
    terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synaptotagmin-11
    Names
    synaptotagmin 12
    synaptotagmin XI

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152280.5NP_689493.3  synaptotagmin-11

      See identical proteins and their annotated locations for NP_689493.3

      Status: REVIEWED

      Source sequence(s)
      AA824539, AL139128, BC004291, DA239014
      Consensus CDS
      CCDS1122.1
      UniProtKB/Swiss-Prot
      Q9BT88
      Related
      ENSP00000357307.4, ENST00000368324.5
      Conserved Domains (2) summary
      cd08388
      Location:158283
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:292429
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      155859502..155885199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000759.2XP_016856248.1  synaptotagmin-11 isoform X1

    2. XM_005245014.3XP_005245071.1  synaptotagmin-11 isoform X2

      Conserved Domains (2) summary
      cd08388
      Location:158283
      C2A_Synaptotagmin-4-11; C2A domain first repeat present in Synaptotagmins 4 and 11
      cd08404
      Location:292428
      C2B_Synaptotagmin-4; C2 domain second repeat present in Synaptotagmin 4
    Support Center