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    Nppa natriuretic peptide type A [ Mus musculus (house mouse) ]

    Gene ID: 230899, updated on 29-Oct-2024

    Summary

    Official Symbol
    Nppaprovided by MGI
    Official Full Name
    natriuretic peptide type Aprovided by MGI
    Primary source
    MGI:MGI:97367
    See related
    Ensembl:ENSMUSG00000041616 AllianceGenome:MGI:97367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ANP; Anf; CDD; Pnd
    Summary
    This gene encodes members of the natriuretic family of peptides that play an important role in the control of extracellular fluid volume and electrolyte homeostasis. The encoded protein precursor undergoes proteolytic processing to generate multiple functional peptides. Mice lacking the encoded peptides exhibit salt-sensitive hypertension. The transgenic overexpression of the encoded peptides in mice decreases arterial blood pressure without inducing diuresis and natriuresis. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 4. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward heart adult (RPKM 1334.2) See more
    Orthologs
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    Genomic context

    See Nppa in Genome Data Viewer
    Location:
    4 E1; 4 78.66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148085179..148086531)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148000722..148002074)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2510039O18 gene Neighboring gene STARR-positive B cell enhancer ABC_E2145 Neighboring gene natriuretic peptide type B Neighboring gene chloride channel, voltage-sensitive 6 Neighboring gene STARR-seq mESC enhancer starr_12064 Neighboring gene Mthfr promoter region Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene methylenetetrahydrofolate reductase Neighboring gene predicted gene 13201

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neuropeptide receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neuropeptide receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cGMP biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of cardiac muscle hypertrophy in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of collecting lymphatic vessel constriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of systemic arterial blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuropeptide signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cGMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of delayed rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of potassium ion export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of atrial cardiac muscle cell membrane repolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of atrial cardiac muscle cell membrane repolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic signaling via neuropeptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glycinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mast cell granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    natriuretic peptides A
    Names
    atrial natriuretic factor prohormone
    atrial natriuretic peptide prohormone
    atriopeptigen
    cardiodilatin
    natriuretic peptide precursor type A
    preproANF
    preproANP
    preproCDD-ANF
    prepronatriodilatin
    proANF
    proANP

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008725.3NP_032751.1  natriuretic peptides A preproprotein

      See identical proteins and their annotated locations for NP_032751.1

      Status: REVIEWED

      Source sequence(s)
      AK147180, AL714013, AV005725
      Consensus CDS
      CCDS18927.1
      UniProtKB/Swiss-Prot
      P05125, Q5FW59
      Related
      ENSMUSP00000099520.5, ENSMUST00000103230.5
      Conserved Domains (1) summary
      smart00183
      Location:122145
      NAT_PEP; Natriuretic peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148085179..148086531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)