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    EXOSC7 exosome component 7 [ Homo sapiens (human) ]

    Gene ID: 23016, updated on 5-Sep-2021

    Summary

    Official Symbol
    EXOSC7provided by HGNC
    Official Full Name
    exosome component 7provided by HGNC
    Primary source
    HGNC:HGNC:28112
    See related
    Ensembl:ENSG00000075914 MIM:606488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p8; EAP1; RRP42; Rrp42p; hRrp42p
    Expression
    Ubiquitous expression in adrenal (RPKM 11.2), skin (RPKM 10.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EXOSC7 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44975291..45012668)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45017736..45054160)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3821 Neighboring gene transglutaminase 4 Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene ribosomal protein L12 pseudogene 44 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene CUB domain containing protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    GeneReviews: Not available

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, exosome component 7 (EXOSC7), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ26543, KIAA0116

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT enables exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in U1 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in U5 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic catabolism of deadenylated mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear polyadenylation-dependent tRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in rRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of exosome (RNase complex) TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    exosome complex component RRP42
    Names
    exosome complex exonuclease RRP42
    ribosomal RNA-processing protein 42
    NP_055819.2
    XP_016861419.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015004.4NP_055819.2  exosome complex component RRP42

      See identical proteins and their annotated locations for NP_055819.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein.
      Source sequence(s)
      AC104165, AK315741, BC012831
      Consensus CDS
      CCDS2725.1
      UniProtKB/Swiss-Prot
      Q15024
      UniProtKB/TrEMBL
      A0A024R2P7, B2RDZ9
      Related
      ENSP00000265564.7, ENST00000265564.8
      Conserved Domains (2) summary
      cd11367
      Location:6276
      RNase_PH_RRP42; RRP42 subunit of eukaryotic exosome
      COG2123
      Location:1273
      Rrp42; Exosome complex RNA-binding protein Rrp42, RNase PH superfamily [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_023353.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) omits two coding exons resulting in a frameshift and prematurely truncated open reading frame. The transcript is a candidate for nonsense-mediated decay.
      Source sequence(s)
      AC104165, AK130053, AK315741, BC012831, BU153856

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      44975291..45012668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005930.2XP_016861419.1  exosome complex component RRP42 isoform X1

    RNA

    1. XR_001740061.1 RNA Sequence

      Related
      ENST00000461361.5
    2. XR_001740062.1 RNA Sequence

    3. XR_245104.4 RNA Sequence

      Related
      ENST00000491476.5
    4. XR_940394.3 RNA Sequence

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