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    MYH15 myosin heavy chain 15 [ Homo sapiens (human) ]

    Gene ID: 22989, updated on 15-Jun-2019

    Summary

    Official Symbol
    MYH15provided by HGNC
    Official Full Name
    myosin heavy chain 15provided by HGNC
    Primary source
    HGNC:HGNC:31073
    See related
    Ensembl:ENSG00000144821 MIM:609929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See MYH15 in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (108380369..108549462, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108099216..108248169, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 57 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 17 Neighboring gene HERV-H LTR-associating 2 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene cell proliferation regulating inhibitor of protein phosphatase 2A Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene uncharacterized LOC105374033

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Translocation of GLUT4 to the plasma membrane, organism-specific biosystem (from REACTOME)
      Translocation of GLUT4 to the plasma membrane, organism-specific biosystemIn adipocytes and myocytes insulin signaling causes intracellular vesicles carrying the GLUT4 (SLC2A4) glucose transporter to translocate to the plasma membrane, allowing the cells to take up glucose...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    extraocular skeletal muscle development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    myofibril IEA
    Inferred from Electronic Annotation
    more info
     
    myosin filament IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    myosin-15
    Names
    myosin, heavy polypeptide 15

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014981.2NP_055796.1  myosin-15 precursor

      See identical proteins and their annotated locations for NP_055796.1

      Status: VALIDATED

      Source sequence(s)
      AB023217, AC069499, AC135308, AK126801
      Consensus CDS
      CCDS43127.1
      UniProtKB/Swiss-Prot
      Q9Y2K3
      Related
      ENSP00000273353.3, ENST00000273353.3
      Conserved Domains (7) summary
      cd14929
      Location:117778
      MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
      pfam00063
      Location:105778
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8591935
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:5290
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam13094
      Location:10171164
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      pfam14235
      Location:18641940
      DUF4337; Domain of unknown function (DUF4337)
      cl19511
      Location:14871600
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      108380368..108549462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512559.2XP_011510861.1  myosin-15 isoform X1

      See identical proteins and their annotated locations for XP_011510861.1

      UniProtKB/Swiss-Prot
      Q9Y2K3
      Conserved Domains (7) summary
      cd14929
      Location:117778
      MYSc_Myh15_mammals; class II myosin heavy chain 15, motor domain
      pfam00063
      Location:105778
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:8591935
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:5290
      Myosin_N; Myosin N-terminal SH3-like domain
      pfam13094
      Location:10171164
      CENP-Q; CENP-Q, a CENPA-CAD centromere complex subunit
      pfam14235
      Location:18641940
      DUF4337; Domain of unknown function (DUF4337)
      cl19511
      Location:14871600
      DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)
    2. XM_017005922.1XP_016861411.1  myosin-15 isoform X2

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