Format

Send to:

Choose Destination
    • Showing Current items.

    CARD8 caspase recruitment domain family member 8 [ Homo sapiens (human) ]

    Gene ID: 22900, updated on 17-Jun-2019

    Summary

    Official Symbol
    CARD8provided by HGNC
    Official Full Name
    caspase recruitment domain family member 8provided by HGNC
    Primary source
    HGNC:HGNC:17057
    See related
    Ensembl:ENSG00000105483 MIM:609051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NDPP; DACAR; DAKAR; NDPP1; TUCAN; CARDINAL
    Summary
    The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
    Expression
    Broad expression in spleen (RPKM 13.6), lymph node (RPKM 11.5) and 24 other tissues See more
    Orthologs

    Genomic context

    See CARD8 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (48203148..48256264, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48711343..48759203, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene DNA ligase 1 Neighboring gene uncharacterized LOC107985293 Neighboring gene zinc finger SWIM-type containing 9 Neighboring gene CARD8 antisense RNA 1 Neighboring gene vomeronasal 1 receptor 97 pseudogene Neighboring gene ZNF114 antisense RNA 1 Neighboring gene zinc finger protein 114 Neighboring gene coiled-coil domain containing 114 Neighboring gene Sharpr-MPRA regulatory region 73

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystem (from WikiPathways)
      Nucleotide-binding Oligomerization Domain (NOD) pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ18119, FLJ18121, KIAA0955, MGC57162, DKFZp779L0366

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CARD domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NACHT domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    NLRP3 inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NLRP3 inflammasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    inflammasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    caspase recruitment domain-containing protein 8
    Names
    CARD inhibitor of NF-kappaB-activating ligands
    apoptotic protein NDPP1
    tumor up-regulated CARD-containing antagonist of CASP9
    tumor up-regulated CARD-containing antagonist of caspase nine

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029574.2 RefSeqGene

      Range
      5324..53184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184900.3NP_001171829.1  caspase recruitment domain-containing protein 8 isoform a

      See identical proteins and their annotated locations for NP_001171829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as T60). Variants 1 and 10 encode the same protein (isoform a).
      Source sequence(s)
      AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
      Consensus CDS
      CCDS54289.1
      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000499211.1, ENST00000651546.1
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    2. NM_001184901.1NP_001171830.1  caspase recruitment domain-containing protein 8 isoform b

      See identical proteins and their annotated locations for NP_001171830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC011466, AK297045, AK297069, BC046136, CA448628
      Consensus CDS
      CCDS12712.2
      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000391248.2, ENST00000447740.6
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find
    3. NM_001184902.2NP_001171831.1  caspase recruitment domain-containing protein 8 isoform c

      See identical proteins and their annotated locations for NP_001171831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
      Consensus CDS
      CCDS54288.1
      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000429839.1, ENST00000520753.5
      Conserved Domains (1) summary
      pfam13553
      Location:182387
      FIIND; Function to find
    4. NM_001184903.1NP_001171832.1  caspase recruitment domain-containing protein 8 isoform c

      See identical proteins and their annotated locations for NP_001171832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a. Variants 4 and 5 encode the same isoform (c).
      Source sequence(s)
      AC011466, AF322184, AK297045, BC046136, CA448628
      Consensus CDS
      CCDS54288.1
      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000430747.1, ENST00000520015.5
      Conserved Domains (1) summary
      pfam13553
      Location:182387
      FIIND; Function to find
    5. NM_001184904.1NP_001171833.1  caspase recruitment domain-containing protein 8 isoform d

      See identical proteins and their annotated locations for NP_001171833.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, 3' coding region, and 3' UTR compared to variant 1. The resulting isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC011466, AI040349, BC046136, DC404273
      Consensus CDS
      CCDS54287.1
      UniProtKB/TrEMBL
      E5RFV9
      Related
      ENSP00000430108.1, ENST00000519332.5
    6. NM_001351782.2NP_001338711.1  caspase recruitment domain-containing protein 8 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1 and 10 encode the same protein (isoform a).
      Source sequence(s)
      AC011466, BC056891, CA448628, CB119078, DC404273, EU118120
      Consensus CDS
      CCDS54289.1
      Related
      ENSP00000428883.1, ENST00000519940.6
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    7. NM_001351783.2NP_001338712.1  caspase recruitment domain-containing protein 8 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC008392, AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
      Consensus CDS
      CCDS12712.2
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find
    8. NM_001351784.2NP_001338713.1  caspase recruitment domain-containing protein 8 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC347384, DC382648, DC404273
      Conserved Domains (2) summary
      pfam00619
      Location:348430
      CARD; Caspase recruitment domain
      pfam13553
      Location:77331
      FIIND; Function to find
    9. NM_001351786.2NP_001338715.1  caspase recruitment domain-containing protein 8 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, CR983845, DC382648, DC404273
      Conserved Domains (2) summary
      pfam00619
      Location:341423
      CARD; Caspase recruitment domain
      pfam13553
      Location:70324
      FIIND; Function to find
    10. NM_001351787.1NP_001338716.1  caspase recruitment domain-containing protein 8 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF143869, AK302327, DC382648, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:77331
      FIIND; Function to find
    11. NM_001351788.2NP_001338717.1  caspase recruitment domain-containing protein 8 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:132337
      FIIND; Function to find
    12. NM_001351789.2NP_001338718.1  caspase recruitment domain-containing protein 8 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, DC382648, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:132337
      FIIND; Function to find
    13. NM_001351790.2NP_001338719.1  caspase recruitment domain-containing protein 8 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, CB119078, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:101306
      FIIND; Function to find
    14. NM_001351791.2NP_001338720.1  caspase recruitment domain-containing protein 8 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC382648, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:77282
      FIIND; Function to find
    15. NM_001351792.2NP_001338721.1  caspase recruitment domain-containing protein 8 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF322184, AF511652, BC056891, CA448628, DA675182, DC347384, DC404273
      Conserved Domains (1) summary
      pfam13553
      Location:77282
      FIIND; Function to find
    16. NM_001365950.1NP_001352879.1  caspase recruitment domain-containing protein 8 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC008392, AC011466
      Conserved Domains (2) summary
      pfam00619
      Location:347429
      CARD; Caspase recruitment domain
      pfam13553
      Location:77330
      FIIND; Function to find
    17. NM_014959.5NP_055774.2  caspase recruitment domain-containing protein 8 isoform b

      See identical proteins and their annotated locations for NP_055774.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a. Variants 2, 3 and 11 encode the same isoform (b).
      Source sequence(s)
      AC011466, AF322184, AF511652, BC045539, BC056891, CA389350, CA448628, DC404273
      Consensus CDS
      CCDS12712.2
      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find

    RNA

    1. NR_033678.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011466, AF322184, CA448628
      Related
      ENST00000518622.5
    2. NR_033679.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011466, BC056891, CA448628, EU118121
    3. NR_033680.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC011466, AF511652, CA448628
    4. NR_147707.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011466, AF143869, AK302327, DC347384, DC404273

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      48203148..48256264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026485.1XP_016881974.1  caspase recruitment domain-containing protein 8 isoform X6

    2. XM_011526650.2XP_011524952.1  caspase recruitment domain-containing protein 8 isoform X14

      See identical proteins and their annotated locations for XP_011524952.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (1) summary
      pfam13553
      Location:182387
      FIIND; Function to find
    3. XM_006723106.4XP_006723169.1  caspase recruitment domain-containing protein 8 isoform X14

      See identical proteins and their annotated locations for XP_006723169.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (1) summary
      pfam13553
      Location:182387
      FIIND; Function to find
    4. XM_017026492.2XP_016881981.1  caspase recruitment domain-containing protein 8 isoform X16

      Conserved Domains (1) summary
      pfam13553
      Location:132337
      FIIND; Function to find
    5. XM_006723097.4XP_006723160.1  caspase recruitment domain-containing protein 8 isoform X3

      See identical proteins and their annotated locations for XP_006723160.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000427858.1, ENST00000521613.5
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find
    6. XM_024451421.1XP_024307189.1  caspase recruitment domain-containing protein 8 isoform X8

      Conserved Domains (2) summary
      pfam00619
      Location:372454
      CARD; Caspase recruitment domain
      pfam13553
      Location:101355
      FIIND; Function to find
    7. XM_017026498.1XP_016881987.1  caspase recruitment domain-containing protein 8 isoform X17

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (1) summary
      pfam13553
      Location:77281
      FIIND; Function to find
    8. XM_006723109.3XP_006723172.1  caspase recruitment domain-containing protein 8 isoform X17

      See identical proteins and their annotated locations for XP_006723172.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (1) summary
      pfam13553
      Location:77281
      FIIND; Function to find
    9. XM_006723104.3XP_006723167.1  caspase recruitment domain-containing protein 8 isoform X11

      See identical proteins and their annotated locations for XP_006723167.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      UniProtKB/TrEMBL
      A0A024QZD3
      Conserved Domains (2) summary
      pfam00619
      Location:347429
      CARD; Caspase recruitment domain
      pfam13553
      Location:77330
      FIIND; Function to find
    10. XM_006723098.3XP_006723161.1  caspase recruitment domain-containing protein 8 isoform X8

      See identical proteins and their annotated locations for XP_006723161.1

      Conserved Domains (2) summary
      pfam00619
      Location:372454
      CARD; Caspase recruitment domain
      pfam13553
      Location:101355
      FIIND; Function to find
    11. XM_006723107.3XP_006723170.1  caspase recruitment domain-containing protein 8 isoform X15

      See identical proteins and their annotated locations for XP_006723170.1

      Conserved Domains (1) summary
      pfam13553
      Location:182348
      FIIND; Function to find
    12. XM_017026499.1XP_016881988.1  caspase recruitment domain-containing protein 8 isoform X18

    13. XM_017026484.2XP_016881973.1  caspase recruitment domain-containing protein 8 isoform X4

    14. XM_017026482.2XP_016881971.1  caspase recruitment domain-containing protein 8 isoform X2

      Conserved Domains (2) summary
      pfam00619
      Location:452534
      CARD; Caspase recruitment domain
      pfam13553
      Location:182435
      FIIND; Function to find
    15. XM_024451422.1XP_024307190.1  caspase recruitment domain-containing protein 8 isoform X9

      Conserved Domains (2) summary
      pfam00619
      Location:371453
      CARD; Caspase recruitment domain
      pfam13553
      Location:101354
      FIIND; Function to find
    16. XM_011526648.3XP_011524950.1  caspase recruitment domain-containing protein 8 isoform X7

      Conserved Domains (2) summary
      pfam00619
      Location:379461
      CARD; Caspase recruitment domain
      pfam13553
      Location:109362
      FIIND; Function to find
    17. XM_006723094.4XP_006723157.1  caspase recruitment domain-containing protein 8 isoform X2

      Conserved Domains (2) summary
      pfam00619
      Location:452534
      CARD; Caspase recruitment domain
      pfam13553
      Location:182435
      FIIND; Function to find
    18. XM_017026483.2XP_016881972.1  caspase recruitment domain-containing protein 8 isoform X3

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find
    19. XM_006723096.4XP_006723159.1  caspase recruitment domain-containing protein 8 isoform X3

      See identical proteins and their annotated locations for XP_006723159.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Related
      ENSP00000428736.1, ENST00000520153.5
      Conserved Domains (2) summary
      pfam00619
      Location:403485
      CARD; Caspase recruitment domain
      pfam13553
      Location:132386
      FIIND; Function to find
    20. XM_011526643.3XP_011524945.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011524945.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    21. XM_006723092.4XP_006723155.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006723155.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    22. XM_011526641.3XP_011524943.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011524943.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    23. XM_006723093.4XP_006723156.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006723156.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    24. XM_011526647.3XP_011524949.1  caspase recruitment domain-containing protein 8 isoform X5

      See identical proteins and their annotated locations for XP_011524949.1

      Conserved Domains (2) summary
      pfam00619
      Location:380462
      CARD; Caspase recruitment domain
      pfam13553
      Location:109363
      FIIND; Function to find
    25. XM_011526646.3XP_011524948.1  caspase recruitment domain-containing protein 8 isoform X5

      See identical proteins and their annotated locations for XP_011524948.1

      Conserved Domains (2) summary
      pfam00619
      Location:380462
      CARD; Caspase recruitment domain
      pfam13553
      Location:109363
      FIIND; Function to find
    26. XM_017026488.2XP_016881977.1  caspase recruitment domain-containing protein 8 isoform X13

      Conserved Domains (2) summary
      pfam00619
      Location:341423
      CARD; Caspase recruitment domain
      pfam13553
      Location:70324
      FIIND; Function to find
    27. XM_024451423.1XP_024307191.1  caspase recruitment domain-containing protein 8 isoform X10

      Conserved Domains (2) summary
      pfam00619
      Location:348430
      CARD; Caspase recruitment domain
      pfam13553
      Location:77331
      FIIND; Function to find
    28. XM_024451425.1XP_024307193.1  caspase recruitment domain-containing protein 8 isoform X12

      Conserved Domains (2) summary
      pfam00619
      Location:343425
      CARD; Caspase recruitment domain
      pfam13553
      Location:72326
      FIIND; Function to find
    29. XM_006723102.4XP_006723165.1  caspase recruitment domain-containing protein 8 isoform X10

      See identical proteins and their annotated locations for XP_006723165.1

      Conserved Domains (2) summary
      pfam00619
      Location:348430
      CARD; Caspase recruitment domain
      pfam13553
      Location:77331
      FIIND; Function to find
    30. XM_006723091.4XP_006723154.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006723154.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    31. XM_024451424.1XP_024307192.1  caspase recruitment domain-containing protein 8 isoform X12

      Conserved Domains (2) summary
      pfam00619
      Location:343425
      CARD; Caspase recruitment domain
      pfam13553
      Location:72326
      FIIND; Function to find
    32. XM_011526644.3XP_011524946.1  caspase recruitment domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011524946.1

      UniProtKB/Swiss-Prot
      Q9Y2G2
      Conserved Domains (2) summary
      pfam00619
      Location:453535
      CARD; Caspase recruitment domain
      pfam13553
      Location:182436
      FIIND; Function to find
    33. XM_017026487.2XP_016881976.1  caspase recruitment domain-containing protein 8 isoform X13

      Conserved Domains (2) summary
      pfam00619
      Location:341423
      CARD; Caspase recruitment domain
      pfam13553
      Location:70324
      FIIND; Function to find
    34. XM_006723110.3XP_006723173.1  caspase recruitment domain-containing protein 8 isoform X19

      See identical proteins and their annotated locations for XP_006723173.1

      UniProtKB/TrEMBL
      E5RFV9
      Related
      ENSP00000427727.1, ENST00000520007.5

    RNA

    1. XR_001753637.2 RNA Sequence

    2. XR_001753636.1 RNA Sequence

    3. XR_430193.3 RNA Sequence

    Support Center