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    INPP5F inositol polyphosphate-5-phosphatase F [ Homo sapiens (human) ]

    Gene ID: 22876, updated on 8-Oct-2018

    Summary

    Official Symbol
    INPP5Fprovided by HGNC
    Official Full Name
    inositol polyphosphate-5-phosphatase Fprovided by HGNC
    Primary source
    HGNC:HGNC:17054
    See related
    Ensembl:ENSG00000198825 MIM:609389; Vega:OTTHUMG00000019158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAC2; hSAC2; MSTP007; MSTPO47
    Summary
    The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in brain (RPKM 17.8), testis (RPKM 4.5) and 22 other tissues See more
    Orthologs

    Genomic context

    See INPP5F in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (119704395..119830482)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121485559..121588663)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene BCL2 associated athanogene 3 Neighboring gene thioredoxin pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 846, pseudogene Neighboring gene uncharacterized LOC105378513 Neighboring gene phosphatase and actin regulator 2 pseudogene 1 Neighboring gene minichromosome maintenance complex binding protein Neighboring gene SEC23 interacting protein Neighboring gene microRNA 4682

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of inositol polyphosphate-5-phosphatase F (INPP5F) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ13081, KIAA0966, MGC59773, MGC131851

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    inositol monophosphate 1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol monophosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    inositol monophosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phosphate 4-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol phosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol phosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT phosphatidylinositol phosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    adult locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle hypertrophy in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    clathrin-dependent endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    phosphatidylinositol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of receptor recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    clathrin-coated endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with clathrin-coated pit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    early endosome membrane TAS
    Traceable Author Statement
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    recycling endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositide phosphatase SAC2
    Names
    Sac domain-containing inositol phosphatase 2
    sac domain-containing phosphoinositide 4-phosphatase 2
    sac domain-containing phosphoinositide 5-phosphatase 2
    NP_001230123.1
    NP_001230124.1
    NP_055752.1
    XP_006717783.1
    XP_011537826.1
    XP_011537827.1
    XP_011537829.2
    XP_011537830.1
    XP_011537831.1
    XP_016871425.1
    XP_024303665.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_044999.1 RefSeqGene

      Range
      98211..108105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243194.1NP_001230123.1  phosphatidylinositide phosphatase SAC2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC027672, AL133461, CN362016, DN992317
      Consensus CDS
      CCDS58098.1
      UniProtKB/Swiss-Prot
      Q9Y2H2
      Related
      ENSP00000496955.1, OTTHUMP00000020609, ENST00000650409.1, OTTHUMT00000050680
      Conserved Domains (1) summary
      pfam12456
      Location:1987
      hSac2; Inositol phosphatase
    2. NM_001243195.1NP_001230124.1  phosphatidylinositide phosphatase SAC2 isoform 3

      See identical proteins and their annotated locations for NP_001230124.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI492073, AI783668, AL158014, BC052367, DB636424
      Consensus CDS
      CCDS81513.1
      UniProtKB/Swiss-Prot
      Q9Y2H2
      Related
      ENSP00000489864.1, OTTHUMP00000281624, ENST00000369081.3, OTTHUMT00000050682
      Conserved Domains (1) summary
      cl27434
      Location:50199
      Syja_N; SacI homology domain
    3. NM_014937.3NP_055752.1  phosphatidylinositide phosphatase SAC2 isoform 1

      See identical proteins and their annotated locations for NP_055752.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB023183, AC027672, AL158014
      Consensus CDS
      CCDS7616.1
      UniProtKB/Swiss-Prot
      Q9Y2H2
      Related
      ENSP00000497527.1, OTTHUMP00000020608, ENST00000650623.1, OTTHUMT00000050679
      Conserved Domains (2) summary
      pfam02383
      Location:50415
      Syja_N; SacI homology domain
      pfam12456
      Location:595697
      hSac2; Inositol phosphatase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      119704395..119830482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539524.3XP_011537826.1  phosphatidylinositide phosphatase SAC2 isoform X1

      Conserved Domains (2) summary
      pfam02383
      Location:38403
      Syja_N; SacI homology domain
      pfam12456
      Location:583685
      hSac2; Inositol phosphatase
    2. XM_006717720.4XP_006717783.1  phosphatidylinositide phosphatase SAC2 isoform X6

      Related
      ENSP00000497368.1, ENST00000649251.1
      Conserved Domains (2) summary
      pfam12456
      Location:595629
      hSac2; Inositol phosphatase
      cl27434
      Location:50567
      Syja_N; SacI homology domain
    3. XM_011539525.3XP_011537827.1  phosphatidylinositide phosphatase SAC2 isoform X3

      See identical proteins and their annotated locations for XP_011537827.1

      Conserved Domains (2) summary
      pfam02383
      Location:73319
      Syja_N; SacI homology domain
      pfam12456
      Location:499601
      hSac2; Inositol phosphatase
    4. XM_024447897.1XP_024303665.1  phosphatidylinositide phosphatase SAC2 isoform X4

      Conserved Domains (2) summary
      pfam12456
      Location:427529
      hSac2; Inositol phosphatase
      cl27434
      Location:7399
      Syja_N; SacI homology domain
    5. XM_017015936.2XP_016871425.1  phosphatidylinositide phosphatase SAC2 isoform X3

      Conserved Domains (2) summary
      pfam02383
      Location:73319
      Syja_N; SacI homology domain
      pfam12456
      Location:499601
      hSac2; Inositol phosphatase
    6. XM_011539527.3XP_011537829.2  phosphatidylinositide phosphatase SAC2 isoform X2

    7. XM_011539528.3XP_011537830.1  phosphatidylinositide phosphatase SAC2 isoform X3

      See identical proteins and their annotated locations for XP_011537830.1

      Related
      ENSP00000497846.1, ENST00000649454.1
      Conserved Domains (2) summary
      pfam02383
      Location:73319
      Syja_N; SacI homology domain
      pfam12456
      Location:499601
      hSac2; Inositol phosphatase
    8. XM_011539529.2XP_011537831.1  phosphatidylinositide phosphatase SAC2 isoform X5

      Conserved Domains (1) summary
      pfam12456
      Location:109211
      hSac2; Inositol phosphatase
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