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    MTF2 metal response element binding transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 22823, updated on 12-May-2019

    Summary

    Official Symbol
    MTF2provided by HGNC
    Official Full Name
    metal response element binding transcription factor 2provided by HGNC
    Primary source
    HGNC:HGNC:29535
    See related
    Ensembl:ENSG00000143033 MIM:609882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M96; PCL2; TDRD19A; dJ976O13.2
    Expression
    Ubiquitous expression in testis (RPKM 5.1), lymph node (RPKM 4.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See MTF2 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (93079219..93139081)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93544792..93604638)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 210, pseudogene Neighboring gene RN7SK pseudogene 123 Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene coiled-coil domain containing 18 Neighboring gene ribosomal protein L36a pseudogene 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from BioSystems

    • Copper homeostasis, organism-specific biosystem (from WikiPathways)
      Copper homeostasis, organism-specific biosystemCopper is a redox-active transition metal and an essential trace element for life. It is a catalytic cofactor for numerous enzymes involved in critical biological processes (eg. detoxyfication by oxy...
    • Endoderm Differentiation, organism-specific biosystem (from WikiPathways)
      Endoderm Differentiation, organism-specific biosystemModel depicting endoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
    • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
      Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Interactome of polycomb repressive complex 2 (PRC2), organism-specific biosystem (from WikiPathways)
      Interactome of polycomb repressive complex 2 (PRC2), organism-specific biosystemA proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics.
    • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
      Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
    • PRC2 methylates histones and DNA, organism-specific biosystem (from REACTOME)
      PRC2 methylates histones and DNA, organism-specific biosystemPolycomb group proteins are responsible for the heritable repression of genes during development (Lee et al. 2006, Ku et al. 2008, reviewed in Simon and Kingston 2009, Margueron and Reinberg 2011, Di...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression, epigenetic TAS
    Traceable Author Statement
    more info
     
    negative regulation of histone H3-K27 methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of histone H3-K27 methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of histone H3-K27 methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    segment specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    stem cell population maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    colocalizes_with ESC/E(Z) complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with ESC/E(Z) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metal-response element-binding transcription factor 2
    Names
    hPCl2
    metal regulatory transcription factor 2
    metal-response element DNA-binding protein M96
    polycomb-like 2
    polycomb-like protein 2
    putative DNA binding protein
    tudor domain containing 19A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164391.1NP_001157863.1  metal-response element-binding transcription factor 2 isoform c

      See identical proteins and their annotated locations for NP_001157863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate portion of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AF072814, AK302776, AL117354, BQ025793, DB173315
      Consensus CDS
      CCDS53341.1
      UniProtKB/Swiss-Prot
      Q9Y483
      UniProtKB/TrEMBL
      B4DZ69, B4DZG1
      Related
      ENSP00000444962.1, ENST00000545708.5
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442488
      Mtf2_C; Polycomb-like MTF2 factor 2
    2. NM_001164392.1NP_001157864.1  metal-response element-binding transcription factor 2 isoform b

      See identical proteins and their annotated locations for NP_001157864.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL117354, BC010013, BQ025793, DB173315
      Consensus CDS
      CCDS53340.1
      UniProtKB/TrEMBL
      Q96G26
      Related
      ENSP00000359326.4, ENST00000370303.4
      Conserved Domains (4) summary
      smart00333
      Location:4595
      TUDOR; Tudor domain
      cd15578
      Location:104156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:203254
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:487533
      Mtf2_C; Polycomb-like MTF2 factor 2
    3. NM_001164393.1NP_001157865.1  metal-response element-binding transcription factor 2 isoform c

      See identical proteins and their annotated locations for NP_001157865.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two coding exons compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AK302900, AL117354, BQ025793, DB173315
      Consensus CDS
      CCDS53341.1
      UniProtKB/Swiss-Prot
      Q9Y483
      UniProtKB/TrEMBL
      B4DZG1
      Related
      ENSP00000443295.1, ENST00000540243.5
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442488
      Mtf2_C; Polycomb-like MTF2 factor 2
    4. NM_007358.4NP_031384.1  metal-response element-binding transcription factor 2 isoform a

      See identical proteins and their annotated locations for NP_031384.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF086908, AJ010014, AL117354, BC001897, BQ025793, CA417978, DB173315
      Consensus CDS
      CCDS742.1
      UniProtKB/Swiss-Prot
      Q9Y483
      UniProtKB/TrEMBL
      Q7Z534
      Related
      ENSP00000359321.4, ENST00000370298.9
      Conserved Domains (4) summary
      smart00333
      Location:4595
      TUDOR; Tudor domain
      cd15578
      Location:104156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:203254
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:544590
      Mtf2_C; Polycomb-like MTF2 factor 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      93079219..93139081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541017.2XP_011539319.1  metal-response element-binding transcription factor 2 isoform X3

      Conserved Domains (3) summary
      smart00333
      Location:4595
      TUDOR; Tudor domain
      cd15578
      Location:104156
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cl22851
      Location:203254
      PHD_SF; PHD finger superfamily
    2. XM_024454115.1XP_024309883.1  metal-response element-binding transcription factor 2 isoform X1

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442488
      Mtf2_C; Polycomb-like MTF2 factor 2
    3. XM_017000678.1XP_016856167.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:385431
      Mtf2_C; Polycomb-like MTF2 factor 2
    4. XM_024454120.1XP_024309888.1  metal-response element-binding transcription factor 2 isoform X4

    5. XM_017000677.1XP_016856166.1  metal-response element-binding transcription factor 2 isoform X2

      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:385431
      Mtf2_C; Polycomb-like MTF2 factor 2
    6. XM_017000679.1XP_016856168.1  metal-response element-binding transcription factor 2 isoform X4

      Conserved Domains (1) summary
      pfam14061
      Location:271317
      Mtf2_C; Polycomb-like MTF2 factor 2
    7. XM_011541019.1XP_011539321.1  metal-response element-binding transcription factor 2 isoform X4

      See identical proteins and their annotated locations for XP_011539321.1

      Conserved Domains (1) summary
      pfam14061
      Location:271317
      Mtf2_C; Polycomb-like MTF2 factor 2
    8. XM_017000676.1XP_016856165.1  metal-response element-binding transcription factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9Y483
      UniProtKB/TrEMBL
      B4DZG1
      Conserved Domains (3) summary
      cd15578
      Location:254
      PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
      cd15580
      Location:101152
      PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
      pfam14061
      Location:442488
      Mtf2_C; Polycomb-like MTF2 factor 2

    RNA

    1. XR_001737043.1 RNA Sequence

    2. XR_001737044.1 RNA Sequence

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