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    COPG1 coatomer protein complex subunit gamma 1 [ Homo sapiens (human) ]

    Gene ID: 22820, updated on 17-Jun-2019

    Summary

    Official Symbol
    COPG1provided by HGNC
    Official Full Name
    coatomer protein complex subunit gamma 1provided by HGNC
    Primary source
    HGNC:HGNC:2236
    See related
    Ensembl:ENSG00000181789 MIM:615525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COPG
    Expression
    Ubiquitous expression in thyroid (RPKM 47.3), prostate (RPKM 41.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See COPG1 in Genome Data Viewer
    Location:
    3q21.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (129249575..129277773)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (128968453..128996616)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S27 pseudogene 12 Neighboring gene uncharacterized LOC105374102 Neighboring gene microRNA 6826 Neighboring gene 5-hydroxymethylcytosine binding, ES cell specific Neighboring gene H1FX antisense RNA 1 Neighboring gene H1 histone family member X

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • COPI-mediated anterograde transport, organism-specific biosystem (from REACTOME)
      COPI-mediated anterograde transport, organism-specific biosystemThe ERGIC (ER-to-Golgi intermediate compartment, also known as vesicular-tubular clusters, VTCs) is a stable, biochemically distinct compartment located adjacent to ER exit sites (Ben-Tekaya et al, 2...
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ21068

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    establishment of Golgi localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    organelle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    organelle transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Golgi membrane TAS
    Traceable Author Statement
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transport vesicle TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    coatomer subunit gamma-1
    Names
    coat protein gamma-cop
    coatomer protein complex, subunit gamma
    coatomer subunit gamma
    gamma-1-COP
    gamma-1-coat protein
    gamma-COP
    gamma-coat protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016128.4NP_057212.1  coatomer subunit gamma-1

      See identical proteins and their annotated locations for NP_057212.1

      Status: VALIDATED

      Source sequence(s)
      AB047846, AC137695, AK025147, BU521557
      Consensus CDS
      CCDS33851.1
      UniProtKB/Swiss-Prot
      Q9Y678
      Related
      ENSP00000325002.6, ENST00000314797.10
      Conserved Domains (2) summary
      COG5240
      Location:7869
      SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
      sd00044
      Location:398423
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      129249575..129277773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512549.2XP_011510851.1  coatomer subunit gamma-1 isoform X1

      Conserved Domains (2) summary
      pfam01602
      Location:23520
      Adaptin_N; Adaptin N terminal region
      sd00044
      Location:398423
      HEAT; HEAT repeat [structural motif]
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