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    Cdc42bpa CDC42 binding protein kinase alpha [ Mus musculus (house mouse) ]

    Gene ID: 226751, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdc42bpaprovided by MGI
    Official Full Name
    CDC42 binding protein kinase alphaprovided by MGI
    Primary source
    MGI:MGI:2441841
    See related
    Ensembl:ENSMUSG00000026490 AllianceGenome:MGI:2441841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DMPK-like; A930014J19Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Acts upstream of or within microtubule cytoskeleton organization and nuclear migration. Located in lamellipodium. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 17.3), cortex adult (RPKM 15.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 H4; 1 84.01 cM
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179787058..179993171)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179960079..180165606)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186 Neighboring gene STARR-seq mESC enhancer starr_03187 Neighboring gene predicted gene, 50608 Neighboring gene STARR-positive B cell enhancer mm9_chr1:182105294-182105595 Neighboring gene predicted gene, 38331 Neighboring gene STARR-positive B cell enhancer ABC_E2024 Neighboring gene STARR-positive B cell enhancer ABC_E1237 Neighboring gene STARR-seq mESC enhancer starr_03189 Neighboring gene coenzyme Q8A Neighboring gene predicted gene, 57491 Neighboring gene predicted gene, 37336

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis. Richard C, et al. Am J Hematol, 2021 Apr 1. PMID 33476437
    2. Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Gomes ER, et al. Cell, 2005 May 6. PMID 15882626
    3. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
    4. DNA methylation in the pathophysiology of hyperphenylalaninemia in the PAH(enu2) mouse model of phenylketonuria. Dobrowolski SF, et al. Mol Genet Metab, 2016 Sep. PMID 26822703, Free PMC Article
    5. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Osipovich AB, et al. Development, 2014 Aug. PMID 25053427, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration.
      Title: MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration.
    2. Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
      Title: Myotonic dystrophy kinase-related CDC42-binding kinase α, a new transferrin receptor type 2-binding partner, is a regulator of erythropoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189823

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK alpha
    Names
    myotonic dystrophy kinase-related CDC-42-binding kinase-alpha
    NP_001028457.1
    NP_001333733.1
    NP_001333734.1
    NP_001346470.1
    NP_001346471.1
    NP_001346472.1
    NP_001346473.1
    NP_001346474.1
    NP_001346475.1
    NP_001346476.1
    NP_001346477.1
    NP_001346478.1
    XP_006496865.1
    XP_006496866.1
    XP_006496867.1
    XP_006496869.1
    XP_006496870.1
    XP_006496872.1
    XP_011237104.1
    XP_011237105.1
    XP_011237106.1
    XP_017175608.1
    XP_017175618.1
    XP_017175619.1
    XP_030109369.1
    XP_030109370.1
    XP_036020077.1
    XP_036020080.1
    XP_036020088.1
    XP_036020093.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033285.1 → NP_001028457.1  serine/threonine-protein kinase MRCK alpha isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      Consensus CDS
      CCDS48466.1
      UniProtKB/TrEMBL
      B2RXX8, E9PVY0
      Related
      ENSMUSP00000106746.2, ENSMUST00000111117.8
      Conserved Domains (8) summary
      pfam08826
      Location:881 → 941
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77 → 343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:482 → 782
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01243
      Location:1072 → 1206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1013 → 1063
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1232 → 1496
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    2. NM_001346804.1 → NP_001333733.1  serine/threonine-protein kinase MRCK alpha isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      Consensus CDS
      CCDS83649.1
      UniProtKB/Swiss-Prot
      B2RY49, Q3UU96, Q4V9U7, Q6ZQA9, Q8R495
      UniProtKB/TrEMBL
      B2RXX8
      Related
      ENSMUSP00000095059.4, ENSMUST00000097450.10

    3. NM_001346805.1 → NP_001333734.1  serine/threonine-protein kinase MRCK alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      Consensus CDS
      CCDS83650.1
      UniProtKB/TrEMBL
      B2RXX8, H7BX44
      Related
      ENSMUSP00000075980.6, ENSMUST00000076687.12

    4. NM_001359541.1 → NP_001346470.1  serine/threonine-protein kinase MRCK alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1059 → 1193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1000 → 1050
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1219 → 1483
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    5. NM_001359542.1 → NP_001346471.1  serine/threonine-protein kinase MRCK alpha isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      Consensus CDS
      CCDS87933.1
      UniProtKB/TrEMBL
      A0A1D5RLQ9, B2RXX8
      Related
      ENSMUSP00000148469.2, ENSMUST00000212756.2
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1029 → 1079
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1248 → 1512
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    6. NM_001359543.1 → NP_001346472.1  serine/threonine-protein kinase MRCK alpha isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1075 → 1209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1016 → 1066
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1235 → 1499
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    7. NM_001359544.1 → NP_001346473.1  serine/threonine-protein kinase MRCK alpha isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      pfam08826
      Location:800 → 860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442 → 861
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:978 → 1112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:919 → 969
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1138 → 1402
      CNH; CNH domain

    8. NM_001359545.1 → NP_001346474.1  serine/threonine-protein kinase MRCK alpha isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      D3YYN8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1039 → 1173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:980 → 1030
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1199 → 1463
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    9. NM_001359546.1 → NP_001346475.1  serine/threonine-protein kinase MRCK alpha isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:373 → 872
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1003 → 1137
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:6 → 336
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:944 → 994
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1163 → 1427
      CNH; CNH domain
      pfam15796
      Location:461 → 539
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    10. NM_001359547.1 → NP_001346476.1  serine/threonine-protein kinase MRCK alpha isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (7) summary
      smart00285
      Location:1483 → 1517
      PBD; P21-Rho-binding domain
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:984 → 1118
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:925 → 975
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1144 → 1408
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    11. NM_001359548.1 → NP_001346477.1  serine/threonine-protein kinase MRCK alpha isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (7) summary
      smart00285
      Location:1470 → 1504
      PBD; P21-Rho-binding domain
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:971 → 1105
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:912 → 962
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1131 → 1395
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    12. NM_001359549.1 → NP_001346478.1  serine/threonine-protein kinase MRCK alpha isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436
      UniProtKB/TrEMBL
      D3YYN8
      Conserved Domains (7) summary
      smart00285
      Location:1434 → 1468
      PBD; P21-Rho-binding domain
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:935 → 1069
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:876 → 926
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1095 → 1359
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. NR_153194.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125380, AC132436

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      179787058..179993171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238803.4 → XP_011237105.1  serine/threonine-protein kinase MRCK alpha isoform X10

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:984 → 1118
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1144 → 1408
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:923 → 982
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    2. XM_030253509.2 → XP_030109369.1  serine/threonine-protein kinase MRCK alpha isoform X11

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (7) summary
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00132
      Location:1465 → 1492
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd01243
      Location:968 → 1102
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:909 → 959
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1128 → 1392
      CNH; CNH domain
      pfam15796
      Location:425 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    3. XM_030253510.2 → XP_030109370.1  serine/threonine-protein kinase MRCK alpha isoform X12

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (7) summary
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00132
      Location:1452 → 1479
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd01243
      Location:955 → 1089
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:896 → 946
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1115 → 1379
      CNH; CNH domain
      pfam15796
      Location:425 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    4. XM_011238804.4 → XP_011237106.1  serine/threonine-protein kinase MRCK alpha isoform X14

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (7) summary
      pfam08826
      Location:696 → 756
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:338 → 757
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00132
      Location:1400 → 1427
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd01243
      Location:903 → 1037
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:844 → 894
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1063 → 1327
      CNH; CNH domain

    5. XM_017320119.3 → XP_017175608.1  serine/threonine-protein kinase MRCK alpha isoform X1

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1248 → 1512
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:1027 → 1086
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    6. XM_006496802.5 → XP_006496865.1  serine/threonine-protein kinase MRCK alpha isoform X2

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1075 → 1209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1016 → 1066
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1235 → 1499
      CNH; CNH domain
      pfam15796
      Location:529 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    7. XM_006496803.5 → XP_006496866.1  serine/threonine-protein kinase MRCK alpha isoform X3

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1072 → 1206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1013 → 1063
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1232 → 1496
      CNH; CNH domain
      pfam15796
      Location:529 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    8. XM_006496804.5 → XP_006496867.1  serine/threonine-protein kinase MRCK alpha isoform X4

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 943
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1062 → 1196
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:1003 → 1053
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1222 → 1486
      CNH; CNH domain
      pfam15796
      Location:529 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    9. XM_006496806.5 → XP_006496869.1  serine/threonine-protein kinase MRCK alpha isoform X5

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 943
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1049 → 1183
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:990 → 1040
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1209 → 1473
      CNH; CNH domain
      pfam15796
      Location:529 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    10. XM_006496807.5 → XP_006496870.1  serine/threonine-protein kinase MRCK alpha isoform X6

      UniProtKB/TrEMBL
      D3YYN8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1039 → 1173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:980 → 1030
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1199 → 1463
      CNH; CNH domain
      pfam15796
      Location:529 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    11. XM_036164184.1 → XP_036020077.1  serine/threonine-protein kinase MRCK alpha isoform X1

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:442 → 941
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:1248 → 1512
      CNH; CNH domain
      pfam15796
      Location:530 → 608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:1027 → 1086
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    12. XM_006496809.5 → XP_006496872.1  serine/threonine-protein kinase MRCK alpha isoform X8

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      pfam08826
      Location:800 → 860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442 → 861
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1007 → 1141
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:948 → 998
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1167 → 1431
      CNH; CNH domain

    13. XM_017320129.3 → XP_017175618.1  serine/threonine-protein kinase MRCK alpha isoform X9

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      pfam08826
      Location:800 → 860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442 → 861
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:994 → 1128
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4 → 412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00130
      Location:935 → 985
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1154 → 1418
      CNH; CNH domain

    14. XM_017320130.3 → XP_017175619.1  serine/threonine-protein kinase MRCK alpha isoform X10

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:984 → 1118
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1144 → 1408
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:923 → 982
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    15. XM_036164187.1 → XP_036020080.1  serine/threonine-protein kinase MRCK alpha isoform X7

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:373 → 872
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1019 → 1153
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:6 → 336
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1179 → 1443
      CNH; CNH domain
      pfam15796
      Location:461 → 539
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:958 → 1017
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    16. XM_036164195.1 → XP_036020088.1  serine/threonine-protein kinase MRCK alpha isoform X10

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:338 → 837
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:984 → 1118
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1144 → 1408
      CNH; CNH domain
      pfam15796
      Location:426 → 504
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:923 → 982
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    17. XM_036164200.1 → XP_036020093.1  serine/threonine-protein kinase MRCK alpha isoform X13

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      pfam08826
      Location:731 → 791
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:373 → 792
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:938 → 1072
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:6 → 336
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1098 → 1362
      CNH; CNH domain
      cd20864
      Location:877 → 936
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    18. XM_011238802.3 → XP_011237104.1  serine/threonine-protein kinase MRCK alpha isoform X7

      UniProtKB/TrEMBL
      B2RXX8
      Conserved Domains (6) summary
      COG0419
      Location:373 → 872
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:1019 → 1153
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:6 → 336
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00780
      Location:1179 → 1443
      CNH; CNH domain
      pfam15796
      Location:461 → 539
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cd20864
      Location:958 → 1017
      C1_MRCKalpha; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCK alpha) and similar proteins

    RNA

    1. XR_001784122.3 RNA Sequence

    2. XR_001784125.3 RNA Sequence

    3. XR_001784127.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UU96.2 GenPept UniProtKB/Swiss-Prot:Q3UU96

    Gene LinkOut

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