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    FES FES proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2242, updated on 8-Jul-2021

    Summary

    Official Symbol
    FESprovided by HGNC
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:3657
    See related
    Ensembl:ENSG00000182511 MIM:190030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPS
    Summary
    This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FES in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90884421..90895776)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91427734..91439006)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 363, pseudogene Neighboring gene Sharpr-MPRA regulatory regions 3826 and 8172 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Biological insights from 108 schizophrenia-associated genetic loci.
    GeneReviews: Not available
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    GeneReviews: Not available
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to vitamin D IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mast cell degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    Oncogene FES, feline sarcoma virus
    feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
    feline sarcoma oncogene
    feline sarcoma/Fujinami avian sarcoma oncogene homolog
    p93c-fes
    proto-oncogene c-Fes
    proto-oncogene c-Fps
    proto-oncogene tyrosine-protein kinase Fes/Fps
    NP_001137255.1
    NP_001137256.1
    NP_001137257.1
    NP_001996.1
    XP_005254937.1
    XP_005254939.1
    XP_016877494.1
    XP_016877495.1
    XP_016877496.1
    XP_016877497.1
    XP_016877498.1
    XP_016877499.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029671.1 RefSeqGene

      Range
      5047..16319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001143783.1NP_001137255.1  tyrosine-protein kinase Fes/Fps isoform 2

      See identical proteins and their annotated locations for NP_001137255.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513656
      Consensus CDS
      CCDS45350.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000377837.3, ENST00000394300.7
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_001143784.1NP_001137256.1  tyrosine-protein kinase Fes/Fps isoform 3

      See identical proteins and their annotated locations for NP_001137256.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513657
      Consensus CDS
      CCDS45349.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000400868.2, ENST00000444422.2
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. NM_001143785.2NP_001137257.1  tyrosine-protein kinase Fes/Fps isoform 4

      See identical proteins and their annotated locations for NP_001137257.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513654, DB264752
      Consensus CDS
      CCDS45351.1
      UniProtKB/Swiss-Prot
      P07332
      Related
      ENSP00000414629.2, ENST00000414248.6
      Conserved Domains (3) summary
      cd05084
      Location:436687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. NM_002005.4NP_001996.1  tyrosine-protein kinase Fes/Fps isoform 1

      See identical proteins and their annotated locations for NP_001996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124248, X52192
      Consensus CDS
      CCDS10365.1
      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Related
      ENSP00000331504.3, ENST00000328850.8
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      90884421..90895776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022008.1XP_016877497.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:436687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_017022006.1XP_016877495.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    3. XM_017022009.2XP_016877498.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase
    4. XM_017022010.1XP_016877499.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    5. XM_005254882.2XP_005254939.1  tyrosine-protein kinase Fes/Fps isoform X3

      See identical proteins and their annotated locations for XP_005254939.1

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    6. XM_005254880.1XP_005254937.1  tyrosine-protein kinase Fes/Fps isoform X2

      See identical proteins and their annotated locations for XP_005254937.1

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (4) summary
      cd10361
      Location:395479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    7. XM_017022005.1XP_016877494.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      P07332
      UniProtKB/TrEMBL
      A0A024RC92
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase
    8. XM_017022007.1XP_016877496.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/Swiss-Prot
      P07332
      Conserved Domains (3) summary
      cd05084
      Location:494745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_001751144.2 RNA Sequence

      Related
      ENST00000464684.5
    2. XR_243206.3 RNA Sequence

    3. XR_001751142.1 RNA Sequence

    4. XR_001751143.1 RNA Sequence

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