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    Vegfc vascular endothelial growth factor C [ Mus musculus (house mouse) ]

    Gene ID: 22341, updated on 17-Oct-2018

    Summary

    Official Symbol
    Vegfcprovided by MGI
    Official Full Name
    vascular endothelial growth factor Cprovided by MGI
    Primary source
    MGI:MGI:109124
    See related
    Ensembl:ENSMUSG00000031520 Vega:OTTMUSG00000060617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VEGF-C; AW228853
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.7), bladder adult (RPKM 4.0) and 27 other tissues See more
    Orthologs

    Genomic context

    See Vegfc in Genome Data Viewer
    Location:
    8; 8 B1.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (54077532..54186454)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (55162886..55271808)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene nei like 3 (E. coli) Neighboring gene uncharacterized protein C12orf41 homolog Neighboring gene predicted gene, 33153 Neighboring gene RIKEN cDNA 5330439A09 gene Neighboring gene signal peptidase complex subunit 3 homolog (S. cerevisiae) Neighboring gene ankyrin repeat and SOCs box-containing 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor 3 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor 3 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor 3 binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    induction of positive chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    induction of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lymphangiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mast cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    vascular endothelial growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    vascular endothelial growth factor C
    Names
    VRP
    flt4 ligand
    flt4-L
    vascular endothelial growth factor C isoform 129
    vascular endothelial growth factor C isoform 184
    vascular endothelial growth factor-related protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009506.2NP_033532.1  vascular endothelial growth factor C precursor

      See identical proteins and their annotated locations for NP_033532.1

      Status: VALIDATED

      Source sequence(s)
      AC120547, AC163012
      Consensus CDS
      CCDS22306.1
      UniProtKB/Swiss-Prot
      P97953
      Related
      ENSMUSP00000033919.4, OTTMUSP00000077097, ENSMUST00000033919.5, OTTMUST00000148273
      Conserved Domains (1) summary
      pfam00341
      Location:127207
      PDGF; PDGF/VEGF domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      54077532..54186454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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